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Specialty: Cytology

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Total 1150 results found since Jan 2013.

Circulating MicroRNAs as Potential Biomarkers for Ischemic Stroke in Patients with Asymptomatic Intracranial Artery Stenosis
Cell Mol Neurobiol. 2022 Jul 28. doi: 10.1007/s10571-022-01259-8. Online ahead of print.ABSTRACTCirculating microRNAs have been shown to be biomarkers of various diseases. We aimed to investigate whether circulating microRNA can serve as a biomarker to predict ischemic stroke risk in asymptomatic intracranial artery stenosis. A total of 716 participants from the Asymptomatic Polyvascular Abnormalities Community study who had asymptomatic intracranial artery stenosis at baseline were enrolled (2010-11). Patients who suffered incident ischemic stroke were classified into the case group, and age- and sex-matched individuals w...
Source: Cellular and Molecular Neurobiology - July 28, 2022 Category: Cytology Authors: Jia Zhang Yuan Shen Kaijiang Kang Jinxi Lin Anxin Wang Shangzhi Li Shouling Wu Xingquan Zhao Qian Zhang Source Type: research

Research Progress on the Mechanisms of Central Post-Stroke Pain: A Review
Cell Mol Neurobiol. 2023 May 11. doi: 10.1007/s10571-023-01360-6. Online ahead of print.ABSTRACTCentral Post-Stroke Pain (CPSP) is a primary sequelae of stroke that can develop in the body part corresponding to the cerebrovascular lesion after stroke, most typically after ischemic stroke but also after hemorrhagic stroke. The pathogenesis of CPSP is currently unknown, and research into its mechanism is ongoing. To summarize current research on the CPSP mechanism and provide guidance for future studies. Use "central post-stroke pain," "stroke AND thalamic pain," "stroke AND neuropathic pain," "post-stroke thalamic pain" as ...
Source: Cellular and Molecular Neurobiology - May 11, 2023 Category: Cytology Authors: Yupei Cheng Bangqi Wu Jingjie Huang Yameng Chen Source Type: research

EXERTION: a pilot trial on the effect of aerobic, smartwatch-controlled exercise on stroke recovery: effects on motor function, structural repair, cognition, mental well-being, and the immune system
This study investigates the effect of smartwatch-controlled aerobic exercise on functional recovery, cognition, emotional well-being, the immune system, and neuronal network reorganization in stroke patients. Trial registration ClinicalTrials.gov NCT Number: NCT05690165. First posted19 January 2023. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05690165.PMID:37170385 | DOI:10.1186/s42466-023-00244-w
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Frederike A Straeten Stephanie van Zyl Bastian Maus Jochen Bauer Heiner Raum Catharina C Gross Sabine Bruchmann Nils C Landmeyer Cornelius Faber Jens Minnerup Antje Schmidt-Pogoda Source Type: research

The Transcriptional Landscape of Pericytes in Acute Ischemic Stroke
This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets.PMID:37378751 | DOI:10.1007/s12975-023-01169-x
Source: Cell Research - June 28, 2023 Category: Cytology Authors: Carolina Buizza Andreas Enstr öm Robert Carlsson Gesine Paul Source Type: research

The myosin start‐of‐power stroke state and how actin binding drives the power stroke
Abstract We propose that on binding to actin at the start of the power stroke the myosin cross‐bridge takes on the rigor configuration at the actin interface. Starting from the pre‐power stroke state, this can be achieved by a small movement (16° rotation) of the lower 50K domain without twisting the central β‐sheet or opening switch‐1 or switch‐2. The movement of the lower 50K domain puts a strain on the W‐helix. This strain tries to twist the β‐sheet, which could drive the power stroke. This would provide a coupling between actin binding and the execution of the power stroke. During the power stroke the ...
Source: Cell Motility and the Cytoskeleton - July 13, 2013 Category: Cytology Authors: Matthias Preller, Kenneth C. Holmes Tags: Research Article Source Type: research

Post stroke hemi-dystonia in children: a neglected area of research
Conclusions Dystonia after CAIS is a common yet insufficiently understood and poorly studied clinical challenge. Studies to improve our understanding of the underlying pathophysiology and consequently the development of instruments for early prediction as well as targeted treatment of dystonia should become a high priority in collaborative childhood stroke research.
Source: Molecular and Cellular Pediatrics - December 11, 2015 Category: Cytology Source Type: research

Safety and therapeutic potential of M2-macrophages in stroke treatment.
Abstract Our objective was to evaluate the safety and clinical efficacy of autologous M2 macrophage transplantation in non-acute stroke patients. We also evaluated whether the intrathecal administration of macrophages influences the production of cytokines by peripheral blood cells, and whether the levels of cytokines correlate with stroke severity and responsiveness to celltherapy. For this, thirteen patients (12 males and one female with median 63 years) diagnosed with ischemic (n=10) or hemorrhagic (n=3) stroke have been subjected to cell transplantation therapy (study group). On average 21.9 x 10(6) of autolog...
Source: Cell Transplantation - December 14, 2015 Category: Cytology Authors: Chernykh ER, Shevela EY, Starostina NM, Morozov SA, Davydova MN, Menyaeva EV, Ostanin AA Tags: Cell Transplant Source Type: research

Stroke serum priming modulates characteristics of mesenchymal stromal cells by controlling the expression miRNA-20a.
Abstract Transplantation of mesenchymal stem cells (MSCs), expanded with fetal bovine serum (FBS), has some limitations, including a long culture period required to obtain sufficient stem cells. Priming of MSCs with serum from patients with ischemic stroke (stroke serum) increased the proliferation rate and the neurorestorative capacity of MSCs. We hypothesized that this novel priming method increases the proliferation rate of MSCs via the regulation of microRNAs (miRs). Thus, we investigated miR profiling in stroke serum primed MSCs and tested whether the regulation of certain miRs may affect the proliferation ra...
Source: Cell Transplantation - January 13, 2016 Category: Cytology Authors: Kim EH, Kim DH, Kim HR, Kim SY, Kim HH, Bang OY Tags: Cell Transplant Source Type: research

Therapeutic effect of ligustilide-stimulated adipose-derived stem cells in a mouse thromboembolic stroke model.
Abstract Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have potential for use in rescue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide isolated from the herb Angelica sinensis exhibits a n...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Chi K, Fu RH, Huang YC, Chen SY, Lin SZ, Huang PC, Lin PC, Chang FK, Liu SP Tags: Cell Transplant Source Type: research

Breaking the blood brain barrier to aid stem cell therapeutics in the chronic stroke brain.
Abstract Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate peripherally delivered stem cells to exert the therapeutic benefits on the stroke brain. Although this BBB permeation-aided stem cell therapy has been demonstrated in the acute stage of stroke, such BBB permeation in the chronic stage of the disease remains to be examined. Adult Sprague-Dawley rats initially received sham surgery or experimental stroke via the one-hour middle cerebral artery occlusion (MCAo) model. At one month after the MCAo surgery, stroke animals were randomly assigned to receive human umbilical cord stem cells ...
Source: Cell Transplantation - February 15, 2016 Category: Cytology Authors: Tajiri N, Lee JY, Acosta S, Sanberg PR, Borlongan CV Tags: Cell Transplant Source Type: research

Methylene Tetrahydrofolate Reductase ( < b > < i > MTHFR < /i > < /b > ) rs868014 Polymorphism Regulated by miR-1203 Associates with Risk and Short Term Outcome of Ischemic Stroke
Conclusion: This study demonstrates that theMTHFR rs868014 SNP is associated with increased risk in developing ischemic stroke, miR-1203 binding, lowMTHFR levels in cells, and poor shot term outcome of patients.Cell Physiol Biochem 2017;41:701 –710
Source: Cellular Physiology and Biochemistry - February 7, 2017 Category: Cytology Source Type: research