Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome
Nature Cell Biology 19, 1379 (2017). doi:10.1038/ncb3622 Author: Xiaoyu Shi, Galo Garcia, Julie C. Van De Weghe, Ryan McGorty, Gregory J. Pazour, Dan Doherty, Bo Huang & Jeremy F. Reiter (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Xiaoyu Shi Galo Garcia Julie C. Van De Weghe Ryan McGorty Gregory J. Pazour Dan Doherty Bo Huang Jeremy F. Reiter Tags: Erratum Source Type: research

TYRP1 mRNA goes fishing for miRNAs in melanoma
Nature Cell Biology 19, 1311 (2017). doi:10.1038/ncb3637 Authors: Maria S. Soengas & Eva Hernando A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Maria S. Soengas Eva Hernando Tags: News and Views Source Type: research

PARPi focus the spotlight on replication fork protection in cancer
Nature Cell Biology 19, 1309 (2017). doi:10.1038/ncb3638 Author: Katharina Schlacher PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Katharina Schlacher Tags: News and Views Source Type: research

Implantable synthetic organoid matrices for intestinal regeneration
Nature Cell Biology 19, 1307 (2017). doi:10.1038/ncb3635 Authors: Jeffrey W. Brown & Jason C. Mills Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Jeffrey W. Brown Jason C. Mills Tags: News and Views Source Type: research

Reforms spell optimism for biological research in China
Nature Cell Biology 19, 1297 (2017). doi:10.1038/ncb3639 A series of government reforms aim to enhance basic research efforts in China with a shift in focus from quantity to quality. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Tags: Editorial Source Type: research

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Nature Cell Biology 19, 1358 (2017). doi:10.1038/ncb3630 Authors: Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M. Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li & Wei Xu (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Fabao Liu Fengfei Ma Yuyuan Wang Ling Hao Hao Zeng Chenxi Jia Yidan Wang Peng Liu Irene   M. Ong Baobin Li Guojun Chen Jiaoyang Jiang Shaoqin Gong Lingjun Li Wei Xu Tags: Article Source Type: research

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair
Nature Cell Biology 19, 1326 (2017). doi:10.1038/ncb3632 Authors: Ricardo Cruz-Acuña, Miguel Quirós, Attila E. Farkas, Priya H. Dedhia, Sha Huang, Dorothée Siuda, Vicky García-Hernández, Alyssa J. Miller, Jason R. Spence, Asma Nusrat & Andrés J. García (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Ricardo Cruz-Acu ñ a Miguel Quir ó s Attila E. Farkas Priya H. Dedhia Sha Huang Doroth é e Siuda Vicky Garc í a-Hern á ndez Alyssa J. Miller Jason R. Spence Asma Nusrat Andr é s J. Garc í a Tags: Article Source Type: research

EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
Nature Cell Biology 19, 1313 (2017). doi:10.1038/ncb3628 Authors: Zarah M. Löf-Öhlin, Pia Nyeng, Matthew E. Bechard, Katja Hess, Eric Bankaitis, Thomas U. Greiner, Jacqueline Ameri, Christopher V. Wright & Henrik Semb (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Zarah M. L ö f- Ö hlin Pia Nyeng Matthew E. Bechard Katja Hess Eric Bankaitis Thomas U. Greiner Jacqueline Ameri Christopher V. Wright Henrik Semb Tags: Article Source Type: research

The impact of cellular metabolism on chromatin dynamics and epigenetics
Nature Cell Biology 19, 1298 (2017). doi:10.1038/ncb3629 Authors: Michael A. Reid, Ziwei Dai & Jason W. Locasale (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Michael A. Reid Ziwei Dai Jason W. Locasale Tags: Review Source Type: research

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Nature Cell Biology 19, 1371 (2017). doi:10.1038/ncb3626 Authors: Beatrice Rondinelli, Ewa Gogola, Hatice Yücel, Alexandra A. Duarte, Marieke van de Ven, Roxanne van der Sluijs, Panagiotis A. Konstantinopoulos, Jos Jonkers, Raphaël Ceccaldi, Sven Rottenberg & Alan D. D’Andrea The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. Dissecting...
Source: Nature Cell Biology - October 16, 2017 Category: Cytology Authors: Beatrice Rondinelli Ewa Gogola Hatice Y ü cel Alexandra A. Duarte Marieke van de Ven Roxanne van der Sluijs Panagiotis A. Konstantinopoulos Jos Jonkers Rapha ë l Ceccaldi Sven Rottenberg Alan D. D ’ Andrea Tags: Letter Source Type: research

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
Nature Cell Biology 19, 1336 (2017). doi:10.1038/ncb3625 Authors: Allison L. Boyd, Jennifer C. Reid, Kyle R. Salci, Lili Aslostovar, Yannick D. Benoit, Zoya Shapovalova, Mio Nakanishi, Deanna P. Porras, Mohammed Almakadi, Clinton J. V. Campbell, Michael F. Jackson, Catherine A. Ross, Ronan Foley, Brian Leber, David S. Allan, Mitchell Sabloff, Anargyros Xenocostas, Tony J. Collins & Mickie Bhatia (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 16, 2017 Category: Cytology Authors: Allison L. Boyd Jennifer C. Reid Kyle R. Salci Lili Aslostovar Yannick D. Benoit Zoya Shapovalova Mio Nakanishi Deanna P. Porras Mohammed Almakadi Clinton J. V. Campbell Michael F. Jackson Catherine A. Ross Ronan Foley Brian Leber David S. Allan Mitchell Tags: Article Source Type: research

A non-coding function of TYRP1 mRNA promotes melanoma growth
Nature Cell Biology 19, 1348 (2017). doi:10.1038/ncb3623 Authors: David Gilot, Mélodie Migault, Laura Bachelot, Fabrice Journé, Aljosja Rogiers, Emmanuelle Donnou-Fournet, Ariane Mogha, Nicolas Mouchet, Marie-Laure Pinel-Marie, Bernard Mari, Tristan Montier, Sébastien Corre, Arthur Gautron, Florian Rambow, Petra El Hajj, Rania Ben Jouira, Sophie Tartare-Deckert, Jean-Christophe Marine, Brice Felden, Ghanem Ghanem & Marie-Dominique Galibert (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2017 Category: Cytology Authors: David Gilot M é lodie Migault Laura Bachelot Fabrice Journ é Aljosja Rogiers Emmanuelle Donnou-Fournet Ariane Mogha Nicolas Mouchet Marie-Laure Pinel-Marie Bernard Mari Tristan Montier S é bastien Corre Arthur Gautron Florian Rambow Petra El Hajj Rania Tags: Article Source Type: research

MK2 balances inflammation and cell death
Nature Cell Biology 19, 1150 (2017). doi:10.1038/ncb3619 Author: Andrew Oberst The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Andrew Oberst Tags: News and Views Source Type: research

Myofibrils put the squeeze on nuclei
Nature Cell Biology 19, 1148 (2017). doi:10.1038/ncb3618 Authors: Jonathan N. Rosen & Mary K. Baylies During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Jonathan N. Rosen Mary K. Baylies Tags: News and Views Source Type: research

What DKKtates where to metastasize
Nature Cell Biology 19, 1146 (2017). doi:10.1038/ncb3621 Authors: Wei Zheng & Jeffrey W. Pollard Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Wei Zheng Jeffrey W. Pollard Tags: News and Views Source Type: research

Retriever fetches integrins from endosomes
Nature Cell Biology 19, 1144 (2017). doi:10.1038/ncb3612 Author: Catherine Rabouille Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Catherine Rabouille Tags: News and Views Source Type: research

Preserving protein function through reversible aggregation
Nature Cell Biology 19, 1142 (2017). doi:10.1038/ncb3620 Author: Jörg Höhfeld It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: J ö rg H ö hfeld Tags: News and Views Source Type: research

A long and winding sTORy
Nature Cell Biology 19, 1131 (2017). doi:10.1038/ncb3624 (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 28, 2017 Category: Cytology Tags: Editorial Source Type: research

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU   tumour suppressor
Nature Cell Biology 19, 1226 (2017). doi:10.1038/ncb3616 Authors: Xiaofeng Wu, Li-shu Zhang, Jason Toombs, Yi-Chun Kuo, John Tyler Piazza, Rubina Tuladhar, Quinn Barrett, Chih-wei Fan, Xuewu Zhang, Loren D. Walensky, Marcel Kool, Steven Y. Cheng, Rolf Brekken, Joseph T. Opferman, Douglas R. Green, Tudor Moldoveanu & Lawrence Lum (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 25, 2017 Category: Cytology Authors: Xiaofeng Wu Li-shu Zhang Jason Toombs Yi-Chun Kuo John Tyler Piazza Rubina Tuladhar Quinn Barrett Chih-wei Fan Xuewu Zhang Loren D. Walensky Marcel Kool Steven Y. Cheng Rolf Brekken Joseph T. Opferman Douglas R. Green Tudor Moldoveanu Lawrence Lum Tags: Article Source Type: research

Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm
Nature Cell Biology 19, 1164 (2017). doi:10.1038/ncb3617 Authors: Kathryn G. V. Anderson, William B. Hamilton, Fabian V. Roske, Ajuna Azad, Teresa E. Knudsen, Maurice A. Canham, Lesley M. Forrester & Joshua M. Brickman (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 25, 2017 Category: Cytology Authors: Kathryn G. V. Anderson William B. Hamilton Fabian V. Roske Ajuna Azad Teresa E. Knudsen Maurice   A. Canham Lesley M. Forrester Joshua M. Brickman Tags: Article Source Type: research

Cell plasticity in epithelial homeostasis and tumorigenesis
Nature Cell Biology 19, 1133 (2017). doi:10.1038/ncb3611 Authors: Julia Varga & Florian R. Greten (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 25, 2017 Category: Cytology Authors: Julia Varga Florian R. Greten Tags: Review Source Type: research

miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS
Nature Cell Biology 19, 1286 (2017). doi:10.1038/ncb3615 Authors: Min-Zu Wu, Wei-Chung Cheng, Su-Feng Chen, Shin Nieh, Carolyn O’Connor, Chia-Lin Liu, Wen-Wei Tsai, Cheng-Jang Wu, Lorena Martin, Yaoh-Shiang Lin, Kou-Juey Wu, Li-Fan Lu & Juan Carlos Izpisua Belmonte (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Min-Zu Wu Wei-Chung Cheng Su-Feng Chen Shin Nieh Carolyn O ’ Connor Chia-Lin Liu Wen-Wei Tsai Cheng-Jang Wu Lorena Martin Yaoh-Shiang Lin Kou-Juey Wu Li-Fan Lu Juan Carlos Izpisua Belmonte Tags: Article Source Type: research

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and   infection
Nature Cell Biology 19, 1248 (2017). doi:10.1038/ncb3614 Authors: Manoj B. Menon, Julia Gropengießer, Jessica Fischer, Lena Novikova, Anne Deuretzbacher, Juri Lafera, Hanna Schimmeck, Nicole Czymmeck, Natalia Ronkina, Alexey Kotlyarov, Martin Aepfelbacher, Matthias Gaestel & Klaus Ruckdeschel (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Manoj B. Menon Julia Gropengie ß er Jessica Fischer Lena Novikova Anne Deuretzbacher Juri Lafera Hanna Schimmeck Nicole Czymmeck Natalia Ronkina Alexey Kotlyarov Martin Aepfelbacher Matthias Gaestel Klaus Ruckdeschel Tags: Article Source Type: research

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Nature Cell Biology 19, 1237 (2017). doi:10.1038/ncb3608 Authors: Yves Dondelinger, Tom Delanghe, Diego Rojas-Rivera, Dario Priem, Tinneke Delvaeye, Inge Bruggeman, Franky Van Herreweghe, Peter Vandenabeele & Mathieu J. M. Bertrand (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Yves Dondelinger Tom Delanghe Diego Rojas-Rivera Dario Priem Tinneke Delvaeye Inge Bruggeman Franky Van Herreweghe Peter Vandenabeele Mathieu J. M. Bertrand Tags: Article Source Type: research

Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny
Nature Cell Biology 19, 1153 (2017). doi:10.1038/ncb3607 Authors: Miguel Ganuza, Trent Hall, David Finkelstein, Ashley Chabot, Guolian Kang & Shannon McKinney-Freeman (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Miguel Ganuza Trent Hall David Finkelstein Ashley Chabot Guolian Kang Shannon McKinney-Freeman Tags: Article Source Type: research

Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1
Nature Cell Biology 19, 1274 (2017). doi:10.1038/ncb3613 Authors: Xueqian Zhuang, Hao Zhang, Xiaoyan Li, Xiaoxun Li, Min Cong, Fangli Peng, Jingyi Yu, Xue Zhang, Qifeng Yang & Guohong Hu (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: Xueqian Zhuang Hao Zhang Xiaoyan Li Xiaoxun Li Min Cong Fangli Peng Jingyi Yu Xue Zhang Qifeng Yang Guohong Hu Tags: Article Source Type: research

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of   Snail1
Nature Cell Biology 19, 1260 (2017). doi:10.1038/ncb3609 Authors: Ji-Hyung Lee, Su Myung Jung, Kyung-Min Yang, Eunjin Bae, Sung Gwe Ahn, Jin Seok Park, Dongyeob Seo, Minbeom Kim, Jihoon Ha, Jaewon Lee, Jun-Hyeong Kim, Jun Hwan Kim, Akira Ooshima, Jinah Park, Donghyuk Shin, Youn Sook Lee, Sangho Lee, Geert van Loo, Joon Jeong, Seong-Jin Kim & Seok Hee Park (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: Ji-Hyung Lee Su Myung Jung Kyung-Min Yang Eunjin Bae Sung Gwe Ahn Jin Seok Park Dongyeob Seo Minbeom Kim Jihoon Ha Jaewon Lee Jun-Hyeong Kim Jun Hwan Kim Akira Ooshima Jinah Park Donghyuk Shin Youn Sook Lee Sangho Lee Geert van Loo Joon Jeong Seong-Jin Ki Tags: Article Source Type: research

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Nature Cell Biology 19, 1214 (2017). doi:10.1038/ncb3610 Authors: Kerrie E. McNally, Rebecca Faulkner, Florian Steinberg, Matthew Gallon, Rajesh Ghai, David Pim, Paul Langton, Neil Pearson, Chris M. Danson, Heike Nägele, Lindsey L. Morris, Amika Singla, Brittany L. Overlee, Kate J. Heesom, Richard Sessions, Lawrence Banks, Brett M. Collins, Imre Berger, Daniel D. Billadeau, Ezra Burstein & Peter J. Cullen (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: Kerrie E. McNally Rebecca Faulkner Florian Steinberg Matthew Gallon Rajesh Ghai David Pim Paul Langton Neil Pearson Chris M. Danson Heike N ä gele Lindsey L. Morris Amika Singla Brittany   L. Overlee Kate J. Heesom Richard Sessions Lawrence Banks Brett Tags: Article Source Type: research

Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle
Nature Cell Biology 19, 1189 (2017). doi:10.1038/ncb3605 Authors: William Roman, João P. Martins, Filomena A. Carvalho, Raphael Voituriez, Jasmine V. G. Abella, Nuno C. Santos, Bruno Cadot, Michael Way & Edgar R. Gomes (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: William Roman Jo ã o P. Martins Filomena A. Carvalho Raphael Voituriez Jasmine V. G. Abella Nuno C. Santos Bruno Cadot Michael Way Edgar R. Gomes Tags: Article Source Type: research

A caspase-independent way to kill cancer cells
Nature Cell Biology 19, 1014 (2017). doi:10.1038/ncb3604 Authors: Brent E. Fitzwalter & Andrew Thorburn Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Brent E. Fitzwalter Andrew Thorburn Tags: News and Views Source Type: research

A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation
Nature Cell Biology 19, 1012 (2017). doi:10.1038/ncb3602 Authors: Clea Bárcena & Carlos López-Otín Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Clea B á rcena Carlos L ó pez-Ot í n Tags: News and Views Source Type: research

Lab-grown mini-brains upgraded
Nature Cell Biology 19, 1010 (2017). doi:10.1038/ncb3601 Authors: Lin Yang & Huck-Hui Ng Three-dimensional brain organoid models have come into the spotlight as in vitro tools to recapitulate complex features of the brain. Four recent papers now leverage current technologies to generate new flavours of brain organoids and address aspects of brain biology which, to date, have been challenging to explore. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Lin Yang Huck-Hui Ng Tags: News and Views Source Type: research

DNA sensing in senescence
Nature Cell Biology 19, 1008 (2017). doi:10.1038/ncb3603 Authors: Marina Ruiz de Galarreta & Amaia Lujambio Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Marina Ruiz de Galarreta Amaia Lujambio Tags: News and Views Source Type: research

Enhancing brown fat with NFIA
Nature Cell Biology 19, 1006 (2017). doi:10.1038/ncb3591 Authors: Suzanne N. Shapira & Patrick Seale Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Suzanne N. Shapira Patrick Seale Tags: News and Views Source Type: research

Principles of refereeing
Nature Cell Biology 19, 1005 (2017). doi:10.1038/ncb3606 Peer review is a key element of scientific publishing. Here we discuss what constitutes the ideal referee report. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Tags: Editorial Source Type: research

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress
Nature Cell Biology 19, 1202 (2017). doi:10.1038/ncb3600 Authors: Shady Saad, Gea Cereghetti, Yuehan Feng, Paola Picotti, Matthias Peter & Reinhard Dechant (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Shady Saad Gea Cereghetti Yuehan Feng Paola Picotti Matthias Peter Reinhard Dechant Tags: Article Source Type: research

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert   syndrome
Nature Cell Biology 19, 1178 (2017). doi:10.1038/ncb3599 Authors: Xiaoyu Shi, Galo Garcia, Julie C. Van De Weghe, Ryan McGorty, Gregory J. Pazour, Dan Doherty, Bo Huang & Jeremy F. Reiter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Xiaoyu Shi Galo Garcia Julie C. Van De Weghe Ryan McGorty Gregory J. Pazour Dan Doherty Bo Huang Jeremy F. Reiter Tags: Article Source Type: research

Mitochondrial permeabilization engages NF- κ B-dependent anti-tumour activity under caspase   deficiency
Nature Cell Biology 19, 1116 (2017). doi:10.1038/ncb3596 Authors: Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, Florian Bock, Catherine Cloix, Kai Cao, Alba Roca, Jonathan Lopez, Gabriel Ichim, Emma Proïcs, Camila Rubio-Patiño, Loic Fort, Nader Yatim, Emma Woodham, Susana Orozco, Lucia Taraborrelli, Nieves Peltzer, Daniele Lecis, Laura Machesky, Henning Walczak, Matthew L. Albert, Simon Milling, Andrew Oberst, Jean-Ehrland Ricci, Kevin M. Ryan, Karen Blyth & Stephen W. G. Tait (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Evangelos Giampazolias Barbara Zunino Sandeep Dhayade Florian Bock Catherine Cloix Kai Cao Alba Roca Jonathan Lopez Gabriel Ichim Emma Pro ï cs Camila Rubio-Pati ñ o Loic Fort Nader Yatim Emma Woodham Susana Orozco Lucia Taraborrelli Nieves Peltzer Dani Tags: Article Source Type: research

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
Nature Cell Biology 19, 1037 (2017). doi:10.1038/ncb3598 Authors: Maria Skamagki, Cristina Correia, Percy Yeung, Timour Baslan, Samuel Beck, Cheng Zhang, Christian A. Ross, Lam Dang, Zhong Liu, Simona Giunta, Tzu-Pei Chang, Joye Wang, Aparna Ananthanarayanan, Martina Bohndorf, Benedikt Bosbach, James Adjaye, Hironori Funabiki, Jonghwan Kim, Scott Lowe, James J. Collins, Chi-Wei Lu, Hu Li, Rui Zhao & Kitai Kim (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Maria Skamagki Cristina Correia Percy Yeung Timour Baslan Samuel Beck Cheng Zhang Christian   A. Ross Lam Dang Zhong Liu Simona Giunta Tzu-Pei Chang Joye Wang Aparna Ananthanarayanan Martina Bohndorf Benedikt Bosbach James Adjaye Hironori Funabiki Jonghw Tags: Article Source Type: research

A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression
Nature Cell Biology 19, 1105 (2017). doi:10.1038/ncb3595 Authors: Simon Grelet, Laura A. Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy, Vamsi K. Gangaraju, J. Alan Diehl & Philip H. Howe (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Simon Grelet Laura A. Link Breege Howley Cl é mence Obellianne Viswanathan Palanisamy Vamsi K. Gangaraju J. Alan Diehl Philip H. Howe Tags: Article Source Type: research

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
Nature Cell Biology 19, 1093 (2017). doi:10.1038/ncb3597 Authors: Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G. Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q. Du, David J. Adams & Brian J. P. Huntly (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Sarah J. Horton George Giotopoulos Haiyang Yun Shabana Vohra Olivia Sheppard Rachael Bashford-Rogers Mamunur Rashid Alexandra Clipson Wai-In Chan Daniel Sasca Loukia Yiangou Hikari Osaki Faisal Basheer Paolo Gallipoli Natalie Burrows Ay ş eg ü l Erdem A Tags: Article Source Type: research

SMC complexes differentially compact mitotic chromosomes according to genomic context
Nature Cell Biology 19, 1071 (2017). doi:10.1038/ncb3594 Authors: Stephanie Andrea Schalbetter, Anton Goloborodko, Geoffrey Fudenberg, Jon-Matthew Belton, Catrina Miles, Miao Yu, Job Dekker, Leonid Mirny & Jonathan Baxter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Stephanie Andrea Schalbetter Anton Goloborodko Geoffrey Fudenberg Jon-Matthew Belton Catrina Miles Miao Yu Job Dekker Leonid Mirny Jonathan Baxter Tags: Article Source Type: research

An apical MRCK-driven morphogenetic pathway controls epithelial polarity
Nature Cell Biology 19, 1049 (2017). doi:10.1038/ncb3592 Authors: Ceniz Zihni, Evi Vlassaks, Stephen Terry, Jeremy Carlton, Thomas King Chor Leung, Michael Olson, Franck Pichaud, Maria Susana Balda & Karl Matter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Ceniz Zihni Evi Vlassaks Stephen Terry Jeremy Carlton Thomas King Chor Leung Michael Olson Franck Pichaud Maria Susana Balda Karl Matter Tags: Article Source Type: research

NFIA co-localizes with PPAR γ and transcriptionally controls the brown fat gene program
Nature Cell Biology 19, 1081 (2017). doi:10.1038/ncb3590 Authors: Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake, Gaku Nagano, Ryo Nakaki, Ken Suzuki, Hirofumi Kobayashi, Shogo Yamamoto, Wei Sun, Tomohisa Aoyama, Yusuke Hirota, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Andrew P. White, Yu-Hua Tseng, Aaron M. Cypess, Therese J. Larsen, Naja Z. Jespersen, Camilla Scheele, Shuichi Tsutsumi, Hiroyuki Aburatani, Toshimasa Yamauchi & Takashi Kadowaki (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2017 Category: Cytology Authors: Yuta Hiraike Hironori Waki Jing Yu Masahiro Nakamura Kana Miyake Gaku Nagano Ryo Nakaki Ken Suzuki Hirofumi Kobayashi Shogo Yamamoto Wei Sun Tomohisa Aoyama Yusuke Hirota Haruya Ohno Kenji Oki Masayasu Yoneda Andrew P. White Yu-Hua Tseng Aaron M. Cypess T Tags: Article Source Type: research

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
Nature Cell Biology 19, 1027 (2017). doi:10.1038/ncb3593 Authors: John C. Schell, Dona R. Wisidagama, Claire Bensard, Helong Zhao, Peng Wei, Jason Tanner, Aimee Flores, Jeffrey Mohlman, Lise K. Sorensen, Christian S. Earl, Kristofor A. Olson, Ren Miao, T. Cameron Waller, Don Delker, Priyanka Kanth, Lei Jiang, Ralph J. DeBerardinis, Mary P. Bronner, Dean Y. Li, James E. Cox, Heather R. Christofk, William E. Lowry, Carl S. Thummel & Jared Rutter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2017 Category: Cytology Authors: John C. Schell Dona R. Wisidagama Claire Bensard Helong Zhao Peng Wei Jason Tanner Aimee Flores Jeffrey Mohlman Lise K. Sorensen Christian S. Earl Kristofor A. Olson Ren Miao T. Cameron Waller Don Delker Priyanka Kanth Lei Jiang Ralph J. DeBerardinis Mary Tags: Article Source Type: research

Lactate dehydrogenase activity drives hair follicle stem cell activation
Nature Cell Biology 19, 1017 (2017). doi:10.1038/ncb3575 Authors: Aimee Flores, John Schell, Abigail S. Krall, David Jelinek, Matilde Miranda, Melina Grigorian, Daniel Braas, Andrew C. White, Jessica L. Zhou, Nicholas A. Graham, Thomas Graeber, Pankaj Seth, Denis Evseenko, Hilary A. Coller, Jared Rutter, Heather R. Christofk & William E. Lowry (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2017 Category: Cytology Authors: Aimee Flores John Schell Abigail S. Krall David Jelinek Matilde Miranda Melina Grigorian Daniel Braas Andrew C. White Jessica L. Zhou Nicholas A. Graham Thomas Graeber Pankaj Seth Denis Evseenko Hilary A. Coller Jared Rutter Heather R. Christofk William Tags: Article Source Type: research

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Nature Cell Biology 19, 1061 (2017). doi:10.1038/ncb3586 Authors: Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender & Andrea Ablasser (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 31, 2017 Category: Cytology Authors: Selene Gl ü ck Baptiste Guey Muhammet Fatih Gulen Katharina Wolter Tae-Won Kang Niklas   Arndt Schmacke Anne Bridgeman Jan Rehwinkel Lars Zender Andrea Ablasser Tags: Article Source Type: research

Corrigendum: Pulsatile cell-autonomous contractility drives compaction in the mouse embryo
Nature Cell Biology 19, 1003 (2017). doi:10.1038/ncb3587 Author: Jean-Léon Maître, Ritsuya Niwayama, Hervé Turlier, François Nédélec & Takashi Hiiragi (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Jean-L é on Ma î tre Ritsuya Niwayama Herv é Turlier Fran ç ois N é d é lec Takashi Hiiragi Tags: Corrigendum Source Type: research

Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal – epigenetic combined pathways
Nature Cell Biology 19, 1003 (2017). doi:10.1038/ncb3572 Author: Urs Graf, Elisa A. Casanova, Sarah Wyck, Damian Dalcher, Marco Gatti, Eva Vollenweider, Michal J. Okoniewski, Fabienne A. Weber, Sameera S. Patel, Marc W. Schmid, Jiwen Li, Jafar Sharif, Guido A. Wanner, Haruhiko Koseki, Jiemin Wong, Pawel Pelczar, Lorenza Penengo, Raffaella Santoro & Paolo Cinelli (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Urs Graf Elisa A. Casanova Sarah Wyck Damian Dalcher Marco Gatti Eva Vollenweider Michal J. Okoniewski Fabienne A. Weber Sameera S. Patel Marc W. Schmid Jiwen Li Jafar Sharif Guido A. Wanner Haruhiko Koseki Jiemin Wong Pawel Pelczar Lorenza Penengo Raffae Tags: Corrigendum Source Type: research

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation
Nature Cell Biology 19, 996 (2017). doi:10.1038/ncb3581 Authors: Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe, Yoshitaka Sekido, Jiahuai Han, Hyun Woo Park & Kun-Liang Guan The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the upstream serine/threonine kinases Mst1/2, MAPK4Ks and Lats1/2. Inactivation of these upstream kinases leads to dephosphorylation, stabilization, nuclear translocation and thus activation of the major functional transducers of the Hippo pathway, YAP and it...
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Kimberly C. Lin Toshiro Moroishi Zhipeng Meng Han-Sol Jeong Steven W. Plouffe Yoshitaka Sekido Jiahuai Han Hyun Woo Park Kun-Liang Guan Tags: Letter Source Type: research