Filtered By:
Specialty: Endocrinology
Condition: Stroke

This page shows you your search results in order of relevance. This is page number 19.

Order by Relevance | Date

Total 2154 results found since Jan 2013.

Metformin Treatment in Post-stroke Period Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes.
Abstract We have shown that diabetes impedes vascular repair and causes vasoregression in the brain after stroke but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion injury (I/R) inactivates the p85 subunit of PI3K by nitration and diverts the PI3K-Akt-survival signal to the p38MAPkinase-apoptosis pathway. Nitrotyrosine (NY), Akt and p38 activity, p85 nitration and caspase-3 cleavage were measured in brains from control, diabetic (GK) or GK rats treated with metformin subjected to sham or stroke surgery and in brain microvas...
Source: Diabetes - December 18, 2014 Category: Endocrinology Authors: Abdelsaid M, Prakash R, Li W, Coucha M, Hafez S, Johnson MH, Fagan SC, Ergul A Tags: Diabetes Source Type: research

The association of atopy with incidence of ischemic heart disease, stroke, and diabetes
Abstract Allergy is a systemic inflammatory disease that could theoretically affect the risk of cardiovascular disease (CVD) and diabetes through inflammatory pathways or mast cell-induced coronary spasm. Whether allergy is associated with an increased risk of CVD and diabetes is largely unknown. We investigated the association between atopy as assessed by IgE sensitization, a well-accepted biomarker of allergy, and incidence of ischemic heart disease, stroke, and diabetes in five Danish population-based cohorts. A total of 14,849 participants were included in the study. Atopy was defined as serum-specific IgE po...
Source: Endocrine - March 1, 2015 Category: Endocrinology Source Type: research

Circulating Insulin-like Growth Factor Binding Protein-3 Predicts One-year Outcome after Ischemic Stroke
Conclusion: IGFBP-3 levels after ischemic stroke may independently predict functional outcome after one year.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Ebinger, M.Ipsen, N.Leonards, C. O.Empl, L.Hanne, L.Liman, T.Mai, K.Strasburger, C. J.Spranger, J.Endres, M. Tags: Article Source Type: research

Gliptins‐mediated neuroprotection against stroke requires chronic pre‐treatment and is glucagon‐like peptide‐1 receptor independent
Abstract Gliptins are anti‐type 2 diabetic (T2D) drugs regulating glycaemia by preventing endogenous glucagon‐like peptide‐1 (GLP‐1) degradation. Chronically administered gliptins before experimental stroke can also induce neuroprotection and this effect is potentially relevant to reduce brain damage in high stroke‐risk T2D patients. However, it is unknown: 1) whether acute gliptins‐treatment after stroke (mimicking a post‐hospitalization treatment) is neuroprotective 2) whether gliptins‐mediated neuroprotection occurs via GLP‐1‐receptor (GLP‐1R) activation. To answer these two questions, wt and glp...
Source: Diabetes, Obesity and Metabolism - February 1, 2016 Category: Endocrinology Authors: Vladimer Darsalia, Martin Larsson, Grazyna Lietzau, David Nathanson, Thomas Nyström, Thomas Klein, Cesare Patrone Tags: LETTER TO THE EDITOR Source Type: research

Effect of Emergency Medical Services Use on Hospital Outcomes of Acute Hemorrhagic Stroke.
CONCLUSIONS: EMS transport was associated with lower hospital mortality and disability after acute hemorrhagic stroke. Effect size of EMS use for mortality was significant in patients with long ED LOS. Key  words: emergency medical service; hemorrhagic stroke; mortality; disability. PMID: 26847874 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - February 14, 2016 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Neuroprotection by progesterone after transient cerebral ischemia in stroke-prone spontaneously hypertensive rats.
Abstract We investigated the neuroprotective effects of progesterone (P4) treatment in stroke-prone spontaneously hypertensive rats (SHRSPs) given 60-min transient middle cerebral artery occlusion (tMCAO). The treatment groups were: (1) Wistar-Kyoto (normotensive sham), (2) SHRSP (hypertensive sham), (3) tMCAO SHRSPs (SHRSP+tMCAO), and (4) SHRSP+tMCAO+P4. P4 (8mg/kg) was administered 1h after occlusion and then daily for 14days. We measured cerebral infarction volume, blood pressure and body weight. Behavioral outcomes were analyzed at post-stroke days 3, 9, and 14. To assess morphological protection we measured a...
Source: Hormones and Behavior - June 5, 2016 Category: Endocrinology Authors: Yousuf S, Atif F, Sayeed I, Wang J, Stein DG Tags: Horm Behav Source Type: research

Pre-stroke glycemia in patients with diabetes
Conclusion Insulin treatment and hyperlipidemia are associated with higher HbA1c levels in acute stroke patients with T2D. Poor adherence to diabetes treatment is associated with higher HbA1c levels only among patients with HbA1c ≥8%.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 4, 2017 Category: Endocrinology Source Type: research

Circulating Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 predict Three-months Outcome after Ischemic Stroke
Exp Clin Endocrinol Diabetes 2017; 125: 485-491 DOI: 10.1055/s-0043-103965 Reports on neuroprotective effects of Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) in ischemic brain tissue are inconsistent. The aim of this study was to determine if plasma levels of IGF-1 and IGFBP-3 in acute stroke patients are indicative of 3 months functional outcome. Plasma levels were measured via chemiluminescence immunoassay in heparin blood samples of patients included in the EARLY trial (NCT00562588). Plasma samples were drawn on admission and 8 days post-stroke. Neurological deficits we...
Source: Experimental and Clinical Endocrinology and Diabetes - July 19, 2017 Category: Endocrinology Authors: Armbrust, Moritz Worthmann, Hans Dengler, Reinhard Schumacher, Helmut Lichtinghagen, Ralf Eschenfelder, Christoph Cyrill Endres, Matthias Ebinger, Martin Tags: Article Source Type: research

The association of thyroid stimulation hormone levels with incident ischemic heart disease, incident stroke, and all-cause mortality
ConclusionThe results do not provide evidence of a harmful effect of decreased or increased TSH on IHD or stroke in the general population. However, there is some indication of an elevated risk for all-cause mortality with TSH 2.5 –5 mU/l compared with 0.4–2.5 mU/l.
Source: Endocrine - February 9, 2020 Category: Endocrinology Source Type: research

Combined Therapy for Patients after Ischemic Stroke as a Support of Social Adaptability.
CONCLUSION: The results of the research point to the fact, that combined therapy of robotic, psychomotor and cognitive can have positive effect on, and be suitable as a treatment for patients after ischemic stroke, regarding their productive age. Positive results have been therefore overt among all tested areas. PMID: 32304370 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Low ‐density lipoprotein cholesterol and stroke – how low should we go?
AbstractDiabetes is a well ‐established risk factor for both ischemic and hemorrhagic stroke. Individuals with diabetes not only have a higher risk of stroke, they also have worse clinical outcomes after stroke, including poorer neurological recovery, higher rates of stroke recurrence and mortality. In addition to optimizin g glycemia, control of cardiovascular risk factors like hypertension and dyslipidemia is crucial in stroke prevention in subjects with diabetes.
Source: Journal of Diabetes Investigation - May 28, 2020 Category: Endocrinology Authors: David TW Lui, Kathryn CB Tan Tags: EDITORIAL Source Type: research

Brain to periphery in acute ischemic stroke: mechanisms and clinical significance
Front Neuroendocrinol. 2021 Jul 14:100932. doi: 10.1016/j.yfrne.2021.100932. Online ahead of print.ABSTRACTThe social and public health burdens of ischemic stroke have been increasing worldwide. In addition to focal brain damage, acute ischemic stroke (AIS) provokes systemic abnormalities across peripheral organs within the body. AIS profoundly alters the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and immune system, which further yield deleterious organ-specific consequences. Poststroke systemic pathological alterations in turn considerably contribute to the progression of ischemic brain injury, which a...
Source: Frontiers in Neuroendocrinology - July 17, 2021 Category: Endocrinology Authors: Pan Cui Louise D McCullough Junwei Hao Source Type: research