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Specialty: Endocrinology
Condition: Stroke

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Total 2154 results found since Jan 2013.

Illuminating the Effects of Stroke on the Diabetic Brain: Insights From Imaging Neural and Vascular Networks in Experimental Animal Models
Type 1 diabetes is known to cause circulatory problems in the eyes, heart, and limbs, and the brain is no exception. Because of the insidious effects of diabetes on brain circulation, patients with diabetes are two to four times more likely to have an ischemic stroke and are less likely to regain functions that are lost. To provide a more mechanistic understanding of this clinically significant problem, imaging studies have focused on how stroke affects neural and vascular networks in experimental models of type 1 diabetes. The emerging picture is that diabetes leads to maladaptive changes in the cerebrovascular system tha...
Source: Diabetes - June 20, 2016 Category: Endocrinology Authors: Reeson, P.; Jeffery, A.; Brown, C. E. Tags: Perspectives in Diabetes Source Type: research

Alterations in the corticotropin-releasing hormone (CRH) neurocircuitry: Insights into post stroke functional impairments.
Abstract Although it is well accepted that changes in the regulation of the hypothalamic-pituitary adrenal (HPA) axis may increase susceptibility to affective disorders in the general population, this link has been less examined in stroke patients. Yet, the bidirectional association between depression and cardiovascular disease is strong, and stress increases vulnerability to stroke. Corticotropin-releasing hormone (CRH) is the central stress hormone of the HPA axis pathway and acts by binding to CRH receptors (CRHR) 1 and 2, which are located in several stress-related brain regions. Evidence from clinical and ani...
Source: Frontiers in Neuroendocrinology - July 21, 2016 Category: Endocrinology Authors: Barra de la Tremblaye P, Plamondon H Tags: Front Neuroendocrinol Source Type: research

Stroke disclosing primary aldosteronism: Report on three cases and review of the literature.
CONCLUSION: Although cerebrovascular events are quite common in PA, their occurrence as initial feature can be misleading. The association of hypokaliemia and refractory hypertension in ischemic or hemorrhagic strokes should prompt an assessment of the RAAS to rule out PA and initiate adequate management as soon as possible in order to avoid further complications. PMID: 28168953 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - February 2, 2017 Category: Endocrinology Authors: Nasri A, Mansour M, Brahem Z, Kacem A, Hassan AA, Derbali H, Messelmani M, Zaouali J, Mrissa R Tags: Ann Endocrinol (Paris) Source Type: research

Insulin resistance and elevated c-reactive protein among first-degree relatives of ischemic stroke patients
Conclusion First-degree relatives of ischemic stroke patients exhibited hyperinsulinemia, Insulin resistance and dyslipidemia. Insulin resistance, a low grade inflammatory state that leads to increased C-reactive protein which triggers the development of atherosclerosis. So screening for insulin resistance and dyslipidemia in first-degree relatives of ischemic stroke patients may help in preventing adverse vascular events.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 4, 2017 Category: Endocrinology Source Type: research

Incidence of myocardial infarction and stroke in acromegaly patients: results from the German Acromegaly Registry
ConclusionsFor acromegaly patients being treated at specialized centres, the incidence of MIs and strokes does not seem to differ from the general population. Certainty regarding such statements requires large, prospective studies however.
Source: Pituitary - August 14, 2017 Category: Endocrinology Source Type: research

Thyrotoxic Atrial Fibrillation: Factors Associated with Persistence and Risk of Ischemic Stroke.
Conclusion: Persistence of thyrotoxic AF occurred in one-third of patients and spontaneous sinus conversion was unlikely after six months of euthyroidism. High rate of ischemic stroke was observed among patients with persistent thyrotoxic AF and older age. Patients with factors associated with persistent AF, especially older people, should be closely monitored beyond 6 months so that anticoagulation can be initiated in a timely manner to reduce risk of ischemic stroke. PMID: 29379659 [PubMed]
Source: Journal of Thyroid Research - February 1, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Intraosseous Administration of Tissue Plasminogen Activator on a Mobile Stroke Unit.
We describe 3 cases in which tPA was administered via IO access on a mobile stroke unit as part of the Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services (BEST-MSU) trial. No adverse events were observed in the process of obtaining IO access or administering tPA. PMID: 30235055 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - September 21, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.
Abstract Estrogens provide neuroprotection in animal models of stroke, but uterotrophic effects and cancer risk limit translation. Classical estrogen receptors (ER) serve as transcription factors, whereas non-nuclear ER govern numerous cell processes and exert beneficial cardiometabolic effects without uterine or breast cancer growth in mice. Here we determined how non-nuclear ER stimulation with a pathway-preferential estrogen (PaPE-1) impacts stroke outcome in mice.Ovariectomized female mice received vehicle, estradiol (E2), or PaPE-1 before and following transient middle cerebral artery occlusion (tMCAo). MRI a...
Source: Endocrinology - September 25, 2018 Category: Endocrinology Authors: Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM Tags: Endocrinology Source Type: research

Performance of the RACE Score for the Prehospital Identification of Large Vessel Occlusion Stroke in a Suburban/Rural EMS Service.
CONCLUSION: The RACE scale demonstrated acceptable discrimination, yet the sensitivity and positive predictive value were lower in this cohort of EMS professionals in the U.S. than in the original validation study conducted in Spain. Further work is needed to determine the optimal prehospital screening tool for identification of LVO. PMID: 30668202 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - January 23, 2019 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

The Association between Presentation by EMS and EMS Prenotification with Receipt of Intravenous Tissue-type Plasminogen Activator in a State Implementing Stroke Systems of Care.
Authors: Nielsen VM, Dejoie-Stanton C, Song G, Christie A, Guo J, Zachrison KS Abstract Collaboration between emergency medical services (EMS) and hospitals receiving stroke patients is critical to ensure prompt, effective treatment, and is a key component of the stroke systems of care (SSoC). The goal of our study was to evaluate the association between presentation by EMS and EMS prenotification with odds of receiving Tissue-type Plasminogen Activator (IV-tPA) in a state implementing SSoC while rigorously accounting for missing data. We utilized data from the Massachusetts Paul Coverdell Stroke Registry for this ...
Source: Prehospital Emergency Care - September 8, 2019 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Gonadal Hormones and Stroke Risk: PCOS as a Case Study.
Abstract It is well known that stroke incidence and outcome is sex-dependent and influenced by age and gonadal hormones. In post-menopausal and/or aged females, declining estrogen levels increases stroke risk. However, women who experience early menopause also have an increase in stroke risk. This suggests that, regardless of age, gonadal hormones regulate stroke risk and severity. This review discusses prolonged gonadal hormone dysfunction in a common female endocrine disorder known as polycystic ovarian syndrome, PCOS, and the associated increased risk of stroke due to resulting hyperandrogenism and metabolic co...
Source: Frontiers in Neuroendocrinology - July 4, 2020 Category: Endocrinology Authors: Stewart CE, Sohrabji F Tags: Front Neuroendocrinol Source Type: research

Design and derivation of the Austrian Prehospital Stroke Scale (APSS) to predict severe stroke with large vessel occlusion.
Conclusions: The easy assessable 5-item APSS score tended to outperform other LVO scores. Real-life prospective evaluation in prehospital setting is ongoing. PMID: 33201748 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - November 19, 2020 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol
ConclusionPCIME will enable us to assess the role of malnutrition in development of post stroke dementia. This study will help clinicians and researchers develop preventive measures to reduce the burden of stroke and dementia.
Source: Journal of Diabetes and Metabolic Disorders - July 13, 2021 Category: Endocrinology Source Type: research

Corticotropin-releasing factor aggravates ischemic stroke injury by the inflammatory activation of microglia
Endocrinology. 2022 Feb 5:bqac013. doi: 10.1210/endocr/bqac013. Online ahead of print.ABSTRACTIschemic stroke is the second leading cause of death worldwide. Therefore, exploring effective and emerging molecular targets for ischemic stroke is the main task of basic and clinical research. The aim of the present study was to investigate the function of corticotropin-releasing factor (CRF) in ischemic stroke and its related mechanisms, to provide a reference for the treatment of ischemic stroke. CRF, antalarmin or astressin-2B were used to activate or block the CRF1 (CRF receptor 1) or CRF2 (CRF receptor 2) in BV2 cells and a...
Source: Endocrinology - February 9, 2022 Category: Endocrinology Authors: Qiang Wu Yan Feng Ling Liu Yang Liu Xin Liu Liqiao Zhang Yanan Li Liqun Wang Source Type: research