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Neuroendocrine regulation in stroke
Trends Endocrinol Metab. 2023 Mar 13:S1043-2760(23)00036-X. doi: 10.1016/j.tem.2023.02.005. Online ahead of print.ABSTRACTThe neuroendocrine system, a crosstalk between the central nervous system and endocrine glands, balances and controls hormone secretion and their functions. Neuroendocrine pathways and mechanisms often get dysregulated following stroke, leading to altered hormone secretion and aberrant receptor expression. Dysregulation of the hypothalamus-pituitary-thyroid (HPT) axis and hypothalamus-pituitary-adrenal (HPA) axis often led to severe stroke outcomes. Post-stroke complications such as cognitive impairment...
Source: Trends in Endocrinology and Metabolism: TEM - March 15, 2023 Category: Endocrinology Authors: Aishika Datta Chandrima Saha Pratiksha Godse Muskaan Sharma Deepaneeta Sarmah Pallab Bhattacharya Source Type: research

Admission thyroid function in relation to 90-day outcome of acute ischemic stroke
CONCLUSIONS: FT3 and TSH were negatively correlated with poor 90-day outcome in patients with AIS. Measurement of thyroid function on admission may provide independent prognostic information for 90-day outcome of AIS.PMID:37466064
Source: Neuroendocrinology Letters - July 19, 2023 Category: Endocrinology Authors: Qinghua Feng Yunze Li Yuan Zhu YangJingyi Xia Tianrui Zhang Manyan Hu Wenlei Li Minghua Wu Source Type: research

Cerebral neovascularization in diabetes: implications for stroke recovery and beyond.
Abstract Neovascularization is an innate physiologic response by which tissues respond to various stimuli through collateral remodeling (arteriogenesis) and new vessel formation from existing vessels (angiogenesis) or from endothelial progenitor cells (vasculogenesis). Diabetes has a major impact on the neovascularization process but the response varies between different organ systems. While excessive angiogenesis complicates diabetic retinopathy, impaired neovascularization contributes to coronary and peripheral complications of diabetes. How diabetes influences cerebral neovascularization remained unresolved unt...
Source: Diabetes Metab - February 5, 2014 Category: Endocrinology Authors: Ergul A, Abdelsaid M, Fouda AY, Fagan SC Tags: J Cereb Blood Flow Metab Source Type: research

Estrogen-IGF-1 interactions in neuroprotection: Ischemic Stroke as a case study.
Abstract The steroid hormone 17b-estradiol and the peptide hormone insulin-like growth factor (IGF)-1 independently exert neuroprotective actions in neurologic diseases such as stroke. Only a few studies have directly addressed the interaction between the two hormone systems, however, there is a large literature that indicates potentially greater interactions between the 17b-estradiol and IGF-1 systems. The present review focuses on key issues related to this interaction including IGF-1 and sex differences and common activation of second messenger systems. Using ischemic stroke as a case study, this review also fo...
Source: Frontiers in Neuroendocrinology - May 29, 2014 Category: Endocrinology Authors: Sohrabji F Tags: Front Neuroendocrinol Source Type: research

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