Lack of Association between Poor Glycemic Control in T2DM and Subclinical Hypothyroidism.
Conclusion: High prevalence of SCH in T2DM patients suggests that there is a need for regular follow-up to check the progression of SCH to overt hypothyroidism. High serum TSH is not a predictor of poor glycemic control. PMID: 32963752 [PubMed - as supplied by publisher] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - September 24, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Tumor Volume Kinetic Analyses Might Explain Excellent Prognoses in Young Patients with Papillary Thyroid Carcinoma.
Authors: Kasahara T, Miyauchi A, Ito Y, Kudo T, Masuoka H, Higashiyama T, Ito M, Kihara M, Miya A Abstract Introduction: Young patients with papillary thyroid carcinoma (PTC) generally have excellent prognoses despite their often-advanced disease status. The reasons for this excellent prognosis are poorly understood. Objective: To investigate the natural history of PTC in young patients, we compared the observed tumor volume-doubling rate (TV-DR) with the hypothetical tumor volume-doubling rate (hTV-DR) before presentation in young PTC patients. DR is an inverse of the doubling time and indicates the number of ...
Source: Journal of Thyroid Research - August 1, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Diagnosis and Management of Graves' Disease in Thailand: A Survey of Current Practice.
Conclusion: Ultrasound and isotopic studies will be requested only by a small proportion of Thai endocrinologists. Higher physician preference for ATD is similar to Europe, Latin America, and other Asian countries. Geographical differences in the use of ATD, radioactive iodine, and thyroidectomy exist. PMID: 32454522 [PubMed - as supplied by publisher] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 27, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Possible Effects of Perchlorate Contamination of Drinking Water on Thyroid Health.
Conclusion: This study did not find any significant association between perchlorate in drinking water and changes in thyroid hormone levels. Our findings indicate the need for further investigation of this hypothesis using urinary perchlorate as a measure of individual exposure. PMID: 32454966 [PubMed - as supplied by publisher] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 27, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Distribution and Prognostic Significance of Estrogen Receptor α (ERα), Estrogen Receptor β (ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma.
Conclusion: ERα, ERβ, and HER-2 have differential expression and prognostic implications in different TC subtypes. PMID: 32426104 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 20, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Microscopic Positive Tumor Margin Increases Risk for Disease Persistence but Not Recurrence in Patients with Stage T1-T2 Differentiated Thyroid Cancer.
Conclusions: Microscopic positive margin in the histopathology report in patients with low-risk DTC was associated with a higher rate of persistent disease but did not increase the risk of disease recurrence. A close follow-up of biomarkers and occult residual cancerous lesions is needed, especially in the first year. Further studies are needed to determine whether additional therapeutic measures to prevent recurrence are indicated in T1 and T2 DTC with positive microscopic surgical margins. PMID: 32395225 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 13, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Lymph Node Metastasis and Extrathyroidal Extension in Papillary Thyroid Microcarcinoma in Cyprus: Suspicious Subcentimeter Nodules Should Undergo FNA When Multifocality is Suspected.
Conclusion: The presence of LN metastasis and ETE in our PTMC patients in Cyprus is frequent. Neck U/S mapping is a highly reliable and accurate tool in identifying metastatic nodes. LN metastasis is associated with ETE and multifocality. Suspicious subcentimeter nodules should undergo FNA irrespective of size when multifocality is suspected. PMID: 32351678 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 2, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

The Bethesda System for Reporting Thyroid Cytopathology: A Cytohistological Study.
Conclusions: Our study substantiates greater reproducibility among pathologists using TBSRTC to arrive at a precise diagnosis with an added advantage of predicting the risk of malignancy which enables the clinician to plan for follow-up or surgery and also the extent of surgery. PMID: 32351679 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 2, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer.
Conclusions: Our results suggest that not only the appearance of a significant increase in TgAb but also stable concentrations of TgAb should be regarded as a sufficient risk condition for an active search for recurrent or persistent disease. Conversely, a significant decrease in TgAb levels can represent a good prognostic sign. PMID: 32351680 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - May 2, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Superior Approach of Recurrent Laryngeal Nerve: Review of the Literature.
Authors: Fatogoma Issa K, Sidiki D, Naouma C, Kassim D, N'Faly K, Djibril S, Neuilly T, Abdoul Wahab H, Boubacary G, Siaka S, Kadidiatou S, Samba Karim T, Mohamed Amadou K Abstract The identification and dissection of the recurrent laryngeal nerve is essential to guarantee its anatomical and functional integrity. The superior approach of the recurrent nerve is a reliable surgical alternative. Various indications are recognized with a reliable landmark. This is the entry point into the larynx under the inferior horn of the thyroid cartilage. The limits of this technique, namely, the extralaryngeal divisions and the ...
Source: Journal of Thyroid Research - January 19, 2020 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Thyroidectomy in a Surgical Volunteerism Mission: Analysis of 464 Consecutive Cases.
Authors: Latifi R, Gachabayov M, Gogna S, Rivera R Abstract Although surgical volunteer missions (SVMs) have become a popular approach for reducing the burden of surgical disease worldwide, the outcomes of specific procedures in the context of a mission are underreported. The aim of this study was to evaluate outcomes and efficiency of thyroid surgery within a surgical mission. This was a retrospective analysis of medical records of all patients who underwent thyroid surgery within a SVM from 2006 to 2019. Postoperative complication rate was the safety endpoint, whereas length of hospital stay (LOS) was the efficie...
Source: Journal of Thyroid Research - December 25, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

A Hospital-Based Study of Iodine Nutrition Status of Breastfeeding Mothers in Bangladesh.
Authors: Naznin J, Fariduddin M, Hasan M, Atiqur-Rahman M, Sultana N, Anowar-Hossain M, Chowdhury S, Hasanat MA Abstract Adequacy of iodine nutrition status in breastfeeding mothers is vital in preventing iodine deficiency disorder (IDD) in neonates and children. The aim of the study was to assess urinary iodine status in breastfeeding mothers attending Bangabandhu Sheikh Mujib Medical University (BSMMU) hospital in Bangladesh. In this cross-sectional study carried out from January 2014 to January 2015, urinary iodine (UI; μgm/L) level of 266 mothers (age 26.6 ± 4.7 years (mean &plusm...
Source: Journal of Thyroid Research - November 8, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Challenges in Interpreting Thyroid Stimulating Hormone Results in the Diagnosis of Thyroid Dysfunction.
Authors: Razvi S, Bhana S, Mrabeti S Abstract The pituitary hormone, thyrotropin (TSH), is regarded as the primary biomarker for evaluating thyroid function and is useful in guiding treatment with levothyroxine for patients with hypothyroidism. The amplified response of TSH to slight changes in thyroid hormone levels provides a large and easily measured signal in the routine care setting. Laboratories provide reference ranges with upper and lower cutoffs for TSH to define normal thyroid function. The upper limit of the range, used to diagnose subclinical (mild) hypothyroidism, is itself a matter for debate, with au...
Source: Journal of Thyroid Research - November 1, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients.
Conclusion: This study confirmed the association of vitamin D deficiency with hypothyroidism, thyroid autoimmunity, increased volume, nodularity, and vascularity of thyroid gland in hypothyroid patients as well as increased HOMA-IR. It proved the association between HOMA-IR and thyroid autoimmunity. The study proved no association between VDR polymorphisms (Fok1 and Apa1) with either vitamin D levels or TSH levels. PMID: 31534663 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - September 21, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Antithyroid Peroxidase Antibodies in Multinodular Hashimoto's Thyroiditis Indicate a Variant Etiology.
This study analyzes the clinical features and the correlation of anti-TPO levels with diffuse and multinodular forms of HT. Material and Methods: This study was conducted in the Department of General Surgery in a tertiary care hospital in south Tamil Nadu. Patients presenting with clinical features of a thyroid disorder were interviewed and given a detailed clinical, radiological examination and guided FNAC. Those patients diagnosed by FNAC as HT were registered and a sample of 3cc of blood was drawn for T3, T4, TSH, and anti-TPO analysis. All the data were tabulated. Results and Discussion: Of the 212 patients who...
Source: Journal of Thyroid Research - August 22, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Medullary Thyroid Carcinoma: An Update on Imaging.
Authors: Kushchayev SV, Kushchayeva YS, Tella SH, Glushko T, Pacak K, Teytelboym OM Abstract Medullary thyroid carcinoma (MTC), arising from the parafollicular C cells of the thyroid, accounts for 1-2% of thyroid cancers. MTC is frequently aggressive and metastasizes to cervical and mediastinal lymph nodes, lungs, liver, and bones. Although a number of new imaging modalities for directing the management of oncologic patients evolved over the last two decades, the clinical application of these novel techniques is limited in MTC. In this article, we review the biology and molecular aspects of MTC as an important back...
Source: Journal of Thyroid Research - August 1, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Performance of the American Thyroid Association Risk Classification in a Single Center Cohort of Pediatric Patients with Differentiated Thyroid Cancer: A Retrospective Study.
Authors: Alwithenani R, DeBrabandere S, Rachinsky I, MacNeil SD, Badreddine M, Van Uum S Abstract Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy in children. Retrospective studies show conflicting results regarding predictors of persistent and recurrent disease after initial therapy. In 2015, the American Thyroid Association (ATA) proposed a clinical classification system to identify pediatric thyroid cancer patients at risk for persistent/recurrent disease. Material and Methods: We retrospectively included all patients in our registry diagnosed with papillary DTC at &...
Source: Journal of Thyroid Research - July 7, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Treatment Outcomes in Anaplastic Thyroid Cancer.
Conclusions: Anaplastic thyroid cancer patients receiving EBRT to the thyroid area/neck and/or surgical resection had better OS than patients without these therapies, though selection bias likely contributed to improved outcomes since patients who can undergo these therapies tend to have better performance status. Prognosis remains poor overall, and new therapeutic approaches are needed to improve outcomes. PMID: 31249658 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - June 30, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria.
Authors: Akinsete A, Oyenusi E, Odugbemi B, Odugbemi T, Temiye E Abstract Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were analyzed in 8...
Source: Journal of Thyroid Research - April 26, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Thyroid and Pregnancy.
Authors: Vaidya B, Negro R, Poppe K, Rovet J PMID: 30723571 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - February 9, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Predictors of Initial and Sustained Remission in Patients Treated with Antithyroid Drugs for Graves' Hyperthyroidism: The RISG Study.
Authors: Karmisholt J, Andersen SL, Bulow-Pedersen I, Carlé A, Krejbjerg A, Nygaard B Abstract Purpose. To study predictors of attaining (part 1) and sustaining (part 2) remission in patients with Graves' hyperthyroidism (GH) treated with antithyroid drugs (ATD). Methods. In the prospective first part, the included patients were treated with ATD until a prespecified definition of remission (thyrotropin> 0.4 mU/L and TSH-receptor antibodies (TRAb) ≤ 1. 0 IU/L in a patient receiving a methimazole dose ≤ 5 mg/day, on two occasions two months apart) was met, or for 24 months. In the second part, patient...
Source: Journal of Thyroid Research - February 6, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Thyroid Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy: A Single Center Study.
Authors: Zhao W, Li X, Liu X, Lu L, Gao Z Abstract Background: Diabetes mellitus is a common metabolic disease and the prevalence is increasing rapidly. Thyroid disorders including subclinical hypothyroidism (SCH) and low triiodothyronine (T3) syndrome are frequently observed in diabetic patients. We conducted a study to explore thyroid function in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). Methods: We included 103 healthy volunteers, 100 T2DM patients without DN, and 139 with DN. Physical examinations including body mass index and blood pressure and laboratory measurements inc...
Source: Journal of Thyroid Research - January 13, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Symptomatic Primary Hyperparathyroidism as a Risk Factor for Differentiated Thyroid Cancer.
Conclusion: PTC is frequent in patients with symptomatic PHPT. Thyroid nodules in patients with symptomatic PHPT must be studied before parathyroidectomy. In symptomatic PHPT, higher level concentration of parathormone (PTH) was associated with higher risk of DTC. PMID: 30581552 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 26, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Regional Node Distribution in Papillary Thyroid Cancer with Microscopic Metastasis.
Authors: Hurtado-López LM, Ordoñez-Rueda A, Zaldivar-Ramírez FR, Basurto-Kuba E Abstract Background: Optimal neck lymphadenectomy in patients with papillary thyroid cancer (PTC) and microscopic lymph node metastasis needs to be defined in order to aid surgeons in their decision about the best way to proceed in these cases. Methods: Patients who underwent total thyroidectomy and lymphadenectomy at levels IIa to VI were divided into two groups: Group 1 (G1) with macroscopic metastasis detected before surgery and Group 2 (G2) with microscopic metastasis detected in sentinel node during surgery...
Source: Journal of Thyroid Research - December 7, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Feasibility of Endoscopic Thyroidectomy via Axilla and Breast Approaches for Larger Goiters: Widening the Horizons.
Authors: Johri G, Chand G, Gupta N, Sonthineni C, Mishra A, Agarwal G, Mayilvaganan S, Verma AK, Mishra SK Abstract Scarless (in the neck) endoscopic thyroidectomy (SET) has evolved into a cosmetically preferred alternative to conventional thyroidectomy (ConT). Recently many of our patients are demanding SET; however their goitres are larger than the recommended size of 4-6 cm. Our aim was to compare the outcomes of ET for small (
Source: Journal of Thyroid Research - October 31, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Prevalence of Subclinical Hypothyroidism in Acute Coronary Syndrome in Nondiabetics: Detailed Analysis from Consecutive 1100 Patients from Eastern India.
Conclusions: Subclinical thyroid dysfunction is quite prevalent in ACS patients. There are no significant associations between STEMI, Unstable Angina, or NSTEMI patients in terms of thyroid dysfunction neither in single vessel versus multivessel disease involvement. The causative role and outcomes of treatment are still uncertain and need further follow-up. PMID: 30254730 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - September 28, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Lessons from Randomised Clinical Trials for Triiodothyronine Treatment of Hypothyroidism: Have They Achieved Their Objectives?
Authors: Hoermann R, Midgley JEM, Larisch R, Dietrich JW Abstract Randomised controlled trials are deemed to be the strongest class of evidence in evidence-based medicine. Failure of trials to prove superiority of T3/T4 combination therapy over standard LT4 monotherapy has greatly influenced guidelines, while not resolving the ongoing debate. Novel studies have recently produced more evidence from the examination of homeostatic equilibria in humans and experimental treatment protocols in animals. This has exacerbated a serious disagreement with evidence from the clinical trials. We contrasted the weight of statisti...
Source: Journal of Thyroid Research - September 5, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Prevalence and Associations of Hypothyroidism in Indian Patients with Type 2 Diabetes Mellitus.
This study shows that a significant proportion of type 2 diabetes patients suffer from clinical or subclinical hypothyroidism and screening for the same may be appropriate. PMID: 30174822 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - September 5, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Short Stay Thyroid Surgery: Can We Replicate the Same in Low Resource Setting?
Authors: Bansal N, Yadav SK, Mishra SK, Kishore K, Mishra A, Chand G, Agarwal G, Agarwal A, Verma AK Abstract Introduction: The concept of short stay thyroidectomy has been tested and in practice in the developed world; the same has not been replicated in countries with limited resources due to lack of organized healthcare system. So, in this study, we tried to analyze if short stay thyroid surgery can be performed in a cost-effective way in developing countries and also if the endocrine surgical trainee can deliver these services safely. Methods: The study was conducted prospectively from January 2013 to July ...
Source: Journal of Thyroid Research - August 31, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association.
Conclusion: The relationship between ScH and MS in our population is dependent on the presence of hyperglycemia, specifically T2DM diagnosis, findings that vary from those previously reported in Latin American subjects. PMID: 30151097 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - August 29, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Incidence of Second Malignancy in Patients with Papillary Thyroid Cancer from Surveillance, Epidemiology, and End Results 13 Dataset.
Authors: Endo M, Liu JB, Dougan M, Lee JS Abstract Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. In this cohort, 3,200 patients developed SPM, a substantially higher number than in the reference population of 2,749 with observed to expected ratio (O/E) of 1.16 (95% CI; 1.12-1.21). Bone and joint cancer had the highest O/E ratio of 4.26 (95% confidence interval [CI] 2.33-7.15) foll...
Source: Journal of Thyroid Research - July 28, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Spontaneous Slowing and Regressing of Tumor Growth in Childhood/Adolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time.
Authors: Kasahara T, Miyauchi A, Kudo T, Nishihara E, Ito M, Ito Y, Kihara M, Miya A Abstract Background: Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease. The tumor growth of young patients' PTCs might show spontaneous slowing postoperatively. We compared young PTC patients' postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT). Methods: Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998-2016 had biochemi...
Source: Journal of Thyroid Research - June 6, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

The Outcome of Papillary Thyroid Cancer Associated with Graves' Disease: A Case Control Study.
Conclusion: Papillary thyroid cancers associated with Graves' disease show aggressive biological behaviour and favoured site of distant metastases was osseous locations. Early diagnosis by routine screening of Graves' disease patients with ultrasound imaging and aspiration studies is recommended. PMID: 29854383 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - June 3, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres.
Conclusions: As surrogate indices of the systemic inflammatory response, NLR and PLR are inexpensive and universally available from routine blood tests. Although we found higher NLR values in cases of malignancy, NLR and PLR cannot effectively predict the presence of occult papillary microcarcinomas in otherwise benign, multinodular goitres. PMID: 29850011 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - June 2, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Significance of Testing Anti-Thyroid Autoantibodies in Patients with Deranged Thyroid Profile.
Conclusion: As anti-thyroid antibodies are more often present when TSH is deranged, such individuals should be screened for anti-thyroid antibodies. This importance of screening is compounded by the fact that anti-thyroid antibodies may be positive in a significant percentage of elderly people. PMID: 29850012 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - June 2, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Cytomorphological Spectrum of Thyroiditis: A Review of 110 Cases.
Conclusion: The diagnostic cytological features in Hashimoto's thyroiditis are increased background lymphocytes, lymphocytic infiltration of thyroid follicular cell clusters, and Hurthle cells. FNAC remains the "Gold Standard" for diagnosing Hashimoto's thyroiditis. Clinical history, thyroid function, and biochemical parameters are the key for diagnosis of other forms of thyroiditis. PMID: 29686830 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - April 26, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery.
This study was conducted on 49 patients who underwent redo surgery. 61 RLNs were identified and completely exposed. Their functional integrity was evaluated using intraoperative nerve monitoring (IONM). Indications for secondary surgery, anatomical changes secondary to recurrent goiter mass and prior surgery, and results of IONM were studied. Frequent indications for redo surgery were multinodular goiter (MNG) in 19 (38.8%) and results of cytology in 14 (28.5%) patients. The mean time interval between primary and redo thyroid surgery was 23.4 years. We laterally approached 41 (67.2%) thyroid lobes between the sternocleidom...
Source: Journal of Thyroid Research - April 24, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Follicular Thyroid Carcinoma in a Country of Endemic Iodine Deficiency (1994-2013).
Conclusion: Follicular thyroid cancer was the second common thyroid malignancy (35.0%) with a gradual rise in trend over the study period and male-female ratio of 1.5 : 1. Large anterior neck swelling was the commonest clinical presentation of FTC. PMID: 29682275 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - April 24, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?
Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease. PMID: 29479488 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - February 28, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Thyrotoxic Atrial Fibrillation: Factors Associated with Persistence and Risk of Ischemic Stroke.
Conclusion: Persistence of thyrotoxic AF occurred in one-third of patients and spontaneous sinus conversion was unlikely after six months of euthyroidism. High rate of ischemic stroke was observed among patients with persistent thyrotoxic AF and older age. Patients with factors associated with persistent AF, especially older people, should be closely monitored beyond 6 months so that anticoagulation can be initiated in a timely manner to reduce risk of ischemic stroke. PMID: 29379659 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - February 1, 2018 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Corrigendum to "Challenges in Interpretation of Thyroid Function Tests in Pregnant Women with Autoimmune Thyroid Disease".
Corrigendum to "Challenges in Interpretation of Thyroid Function Tests in Pregnant Women with Autoimmune Thyroid Disease". J Thyroid Res. 2017;2017:4324130 Authors: Feldt-Rasmussen U, Bliddal S, Rasmussen ÅK, Boas M, Hilsted L, Main K Abstract [This corrects the article DOI: 10.4061/2011/598712.]. PMID: 29209552 [PubMed - in process] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 8, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

18F-FDG Pet-Guided External Beam Radiotherapy in Iodine-Refractory Differentiated Thyroid Cancer: A Pilot Study.
Conclusions:   18F-FDG PET/CT was useful in target definition for radiotherapy planning, identifying positive areas not detected with 131I scintigraphy. IMRT based EBRT was feasible and our results encourage future prospective studies. This clinical trial is registered with ID: NCT03191643. PMID: 29201490 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 5, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

The End-Diastolic Velocity of Thyroid Arteries Is Strongly Correlated with the Peak Systolic Velocity and Gland Volume in Patients with Autoimmune Thyroiditis.
CONCLUSION: The strong correlation of ITA-EDV with ITA-PSV, TVP, and volume suggests that increased vascularization in CAT may be associated with a reduction in thyroid blood flow resistance, possibly due to an angiogenesis-induced increase in the total vascular cross-sectional area of the parenchyma. PMID: 29062583 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - October 25, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Corrigendum to "The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology".
Corrigendum to "The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology". J Thyroid Res. 2017;2017:6917841 Authors: Fitzgerald SP, Bean NG Abstract [This corrects the article DOI: 10.1155/2016/6351473.]. PMID: 28913003 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - September 17, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Hypermetabolic Thyroid Incidentaloma on Positron Emission Tomography: Review of Laboratory, Radiologic, and Pathologic Characteristics.
CONCLUSION: Most thyroid hypermetabolic incidentalomas are benign lesions, while higher values of SUV max are in favor of malignancy. This mandates further evaluation of incidentally found thyroid hypermetabolic lesions on routine PET/CT scans. PMID: 28913004 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - September 17, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins.
Authors: Kharrazian D, Herbert M, Vojdani A Abstract Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate the potential role of dietary protein immune reactivity with thyroid hormones and thyroid axis target sites. We identified immune reactivity between dietary proteins and target sites on the thyroid axis that includes thyroid hormones, thyroid receptors, enzymes, and transport proteins. We also measure...
Source: Journal of Thyroid Research - September 14, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Outcome, Pain Perception, and Health-Related Quality of Life in Patients Submitted to Percutaneous Ethanol Injection for Simple Thyroid Cysts.
Authors: Negro R, Colosimo E, Greco G Abstract Thyroid cysts are usually benign lesions that when voluminous may induce cosmetic concerns or local discomfort. Percutaneous ethanol injection (PEI) has been demonstrated to be effective for shrinkage of such cysts. In this retrospective study, we evaluated the efficacy, pain perception, and health-related quality of life (HRQL) in patients submitted to PEI for pure cystic lesions. We reviewed the data of 101 patients who underwent ≤3 PEI. In the whole group of patients, the volume reduction was 66% after the first, 74.4% after the second, and 79.4% after the third ...
Source: Journal of Thyroid Research - August 6, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Thyroid Disorders in Central Ghana: The Influence of 20 Years of Iodization.
This study compares the prevalence of thyroid disorders before and after the introduction of iodization. METHODS: This is a retrospective study of thyroid cases from the middle belt of Ghana between 1982 and 2014. To demonstrate a link between iodization and hyperthyroidism and autoimmunity, we compared the prevalence of hyperthyroidism and autoimmune thyroid disorders before and after the iodization programme. RESULTS: A total of 10,484 (7548 females, 2936 males) cases were recorded. The rate of thyroid cases seen was 343/100,000. Nontoxic nodular goiters (25.7%) and toxic nodular goiters (22.5%) represented the s...
Source: Journal of Thyroid Research - July 27, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Ultrasound Risk Categories for Thyroid Nodules and Cytology Results: A Single Institution's Experience after the Adoption of the 2016 Update of Medical Guidelines by the American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi.
CONCLUSIONS: A nonnegligible number of cytologically malignant nodules or nodules that were suspected to be malignant would be missed if intermediate US risk nodules
Source: Journal of Thyroid Research - July 27, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Impact of Obesity on Serum Levels of Thyroid Hormones among Euthyroid Saudi Adults.
Authors: Al-Musa HM Abstract AIM OF STUDY: To assess serum thyroid hormones levels among Saudi adults and to correlate participants' serum levels with their grades of body mass index (BMI). METHODOLOGY: A total of 278 adult subjects were recruited. Participants were categorized according to their BMI grades into normal weight (BMI
Source: Journal of Thyroid Research - June 22, 2017 Category: Endocrinology Tags: J Thyroid Res Source Type: research