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Total 2753 results found since Jan 2013.

Comparison of risk of serious cardiovascular events after haemorrhagic versus ischaemic stroke: a population-based study
CONCLUSIONS: The risk of subsequent cardiovascular events is similar between patients with incident haemorrhagic or ischaemic stroke. Patients with previous haemorrhagic stroke should be regarded as a population at very-high risk of subsequent CVD.PMID:35688459 | DOI:10.1055/a-1873-9092
Source: Thrombosis and Haemostasis - June 10, 2022 Category: Hematology Authors: Ralph Kwame Akyea Georgios Georgiopoulos Barbara Iyen Joe Kai Nadeem Qureshi George Ntaios Source Type: research

Severe stroke: patient profile and predictors of favorable outcome
Conclusions:  Severe stroke presentation is predicted by multiple clinical, radiologic and metabolic variables, several of which are modifiable. Predictors in the 28% of patients with favorable outcome despite presenting with severe stroke include hypolipemic pretreatment, lower acute temperature, lower glucose levels at 24 h, and arterial recanalization.
Source: Journal of Thrombosis and Haemostasis - January 27, 2013 Category: Hematology Authors: O. BILL, P. ZUFFEREY, M. FAOUZI, P. MICHEL Tags: ORIGINAL ARTICLE Source Type: research

Outcome of overt stroke in sickle cell anaemia, a single institution's experience
Summary Stroke is a traumatic complication in sickle cell anaemia (SCA) that is associated with significant morbidity and a risk of recurrent overt stroke of 2·2–6·4 events per 100 patient‐years. A retrospective study was performed on all paediatric SCA patients diagnosed with a history of overt stroke between 1997 and 2010. A total of 31 children with SCA had new onset overt stroke. The mean age of the active patients (n = 27) was 17·9 years (range 6·8–27·6 years) with a total period of observation of 305 patient‐years. Twenty‐two of 27 (81%) were receiving long term red blood cell transfusions and 16 (...
Source: British Journal of Haematology - February 27, 2014 Category: Hematology Authors: Suvankar Majumdar, Morgan Miller, Majid Khan, Catherine Gordon, Amy Forsythe, Mary G. Smith, Gail Megason, Rathi Iyer Tags: Research Paper Source Type: research

Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke.
CONCLUSIONS: Increased MPV is an independent risk factor for both strokes. Elevated PLT count increases the risk for ischemic stroke, but decreases the risk for hemorrhagic stroke. However, neither MPV nor PLT count has significant association with the prognosis of either stroke. PMID: 26992440 [PubMed - as supplied by publisher]
Source: International Journal of Laboratory Hematology - March 19, 2016 Category: Hematology Authors: Du J, Wang Q, He B, Liu P, Chen JY, Quan H, Ma X Tags: Int J Lab Hematol Source Type: research

D-dimer and the Risk of Stroke and Coronary Heart Disease. The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
Abstract D-dimer, a biomarker of coagulation, is higher in blacks than in whites and has been associated with stroke and coronary heart disease (CHD). It was our objective to assess the association of higher D-dimer with stroke and CHD in blacks and whites. REGARDS recruited 30,239 black and white participants across the contiguous US and measured baseline D-dimer in stroke (n=646) and CHD (n=654) cases and a cohort random sample (n=1,104). Cox models adjusting for cardiovascular risk factors determined the hazard ratio (HR) for increasing D-dimer for cardiovascular disease with bootstrapping to assess the differe...
Source: Thrombosis and Haemostasis - December 21, 2016 Category: Hematology Authors: Zakai NA, McClure LA, Judd SE, Kissela B, Howard G, Safford M, Cushman M Tags: Thromb Haemost Source Type: research

Stroke etiologic subtype may influence the rate of hyperdense middle cerebral artery sign disappearance after intravenous thrombolysis
This study suggests that stroke due to LAA is associated with lower rates of HMCAS disappearance, neurologic improvement, and mRS ≤1 after IV thrombolysis, compared with cardioembolic stroke.
Source: Journal of Thrombosis and Thrombolysis - December 31, 2016 Category: Hematology Source Type: research

Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence.
Abstract Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges between vascular sub-endothelial collagen and platelets. The rationale for vWF as a potential target in stroke comes from four bodies of evidence. (1) Animal models which recapitulate the pathogenesis of stroke and validate the concept of targeting vWF for stroke prevention and the use of the...
Source: Thrombosis and Haemostasis - May 31, 2018 Category: Hematology Authors: Buchtele N, Schwameis M, Gilbert JC, Schörgenhofer C, Jilma B Tags: Thromb Haemost Source Type: research

Practice Patterns in the Use of MRI/MRA and Chronic Transfusion Therapy for Monitoring and Treatment of Stroke in Pediatric Patients with Sickle Cell Anemia
Conclusions: The results of the DISPLACE practice patterns survey suggested nearly universal adoption of CRCT for children with abnormal TCD and prior overt stroke across sites. The use of MRI/MRA in detecting potential cerebrovascular abnormalities in the absence of clinical neurologic symptoms and for monitoring patients on CRCT was much more variable, which likely reflects the minimal amount of guidance for the use of MRI/MRA in SCA. Notably, a number of sites were using MRI/MRA to screen pediatric patients for cerebrovascular abnormalities and to monitor patients on CRCT. The variability in responses for MRI/MRA highli...
Source: Blood - November 21, 2018 Category: Hematology Authors: Schlenz, A. M., Mueller, M., Phillips, S., Melvin, C., Adams, R. J., Kanter, J. Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research

Causes and Secondary Prevention of Acute Ischemic Stroke in Adults.
Abstract Stroke still remains a major cause of death and disability worldwide. Ischemic stroke is the most common type of stroke. Causes of ischemic stroke can be classified into large-artery atherosclerosis, cardiogenic embolism, small-vessel disease, stroke of other determined etiology, and stroke of undetermined etiology. Stroke causes in adults are mainly attributable to classical cardiovascular risk factors such as hypertension, diabetes, hypercholesterolemia, and smoking. In neuroimaging, stroke subtypes can be defined according to lesion localization and distribution (territorial infarct, lacunar infarct, h...
Source: Hamostaseologie - October 23, 2019 Category: Hematology Authors: Jensen M, Thomalla G Tags: Hamostaseologie Source Type: research

Increased platelet procoagulant potential predicts recurrent stroke and TIA after lacunar infarction.
CONCLUSIONS: Identification of increased platelet procoagulant potential may improve our ability to identify patients at higher risk of recurrent stroke/TIA following a lacunar stroke. Further study of mechanisms involved is warranted and may yield novel targets for prevention and treatment. PMID: 31858724 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 18, 2019 Category: Hematology Authors: Kirkpatrick AC, Vincent AS, Dale GL, Prodan CI Tags: J Thromb Haemost Source Type: research

Unusually High Prevalence of Stroke and Cerebral Vasculopathy in Hemoglobin SC Disease: A Retrospective Single Institution Study
Conclusion: There is a distinct subset of individuals with HbSC who developed overt, silent stroke, and cerebral vasculopathy. A female predominance and association with Rec VOCs were identified in our cohort; however, larger clinical trials are needed to identify and confirm specific clinical and laboratory markers associated with stroke and vasculopathy in HbSC disease.Acta Haematol
Source: Acta Haematologica - November 8, 2021 Category: Hematology Source Type: research