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Total 2753 results found since Jan 2013.

Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of Pediatric Thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili).
I. T. I. (Registro Italiano Trombosi Infantili) Abstract Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral throm...
Source: Thrombosis and Haemostasis - March 12, 2015 Category: Hematology Authors: Suppiej A, Gentilomo C, Saracco P, Sartori S, Agostini M, Bagna R, Bassi B, Giordano P, Grassi M, Guzzetta A, Lasagni D, Luciani M, Molinari AC, Palmieri A, Putti MC, Ramenghi LA, Rota LL, Sperlì D, Laverda AM, Simioni P, Stroke working group of the R. Tags: Thromb Haemost Source Type: research

Elevated Levels of CD64 MFI on Monocyte Subsets Are Associated with a History of Stroke in Sickle Cell Disease
Conclusion: Levels of monocyte subsets have been shown to correlate with clinical outcomes in non-SCD stroke, but to our knowledge this is the first study to examine their roles in ischemic stroke in SCD. The pathophysiology of stroke in SCD is unique and the role of monocytes in it deserves separate study from the role of monocytes in non-SCD stroke. We saw that while monocyte subsets were associated with a history of ischemic stroke, CD64 MFI on all monocyte subsets showed a strong association. We wonder if this may be due to CD64 MFI being a marker for cells which are more adherent to endothelium as has been shown in pr...
Source: Blood - November 21, 2018 Category: Hematology Authors: Curtis, S. A., Balbuena-Merle, R., Devine, L., Zelterman, D., Roberts, J. D., Dearborn-Tomazos, J., Sansing, L., Hendrickson, J. E. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster I Source Type: research

Association of Stroke Risk Biomarkers with Stroke Symptoms: The Reasons for Geographic And Racial Differences in Stroke Cohort.
CONCLUSIONS: Strong associations of stroke risk biomarkers with stroke symptoms in persons without a clinical history of cerebrovascular disease support a hypothesis that some of these stroke symptoms represent unrecognized cerebrovascular disease. Future work is needed to determine whether these biomarkers identify persons with stroke symptoms who have a particularly high stroke risk. This article is protected by copyright. All rights reserved. PMID: 27813265 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 3, 2016 Category: Hematology Authors: Landry KK, Alexander KS, Zakai NA, Judd SE, Kleindorfer DO, Howard VJ, Howard G, Cushman M Tags: J Thromb Haemost Source Type: research

ABO Blood Type and Stroke Risk: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
CONCLUSION: Blood type AB is associated with an increased risk of stroke that is not attenuated by conventional stroke risk factors and factor VIII levels were associated with 60% of the association. While blood type AB is rare in the U.S. population, it is a significant stroke risk factor and may play an important role in stroke risk in these individuals. This article is protected by copyright. All rights reserved. PMID: 24444093 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 21, 2014 Category: Hematology Authors: Zakai NA, Judd SE, Alexander K, McClure LA, Kissela BM, Howard G, Cushman M Tags: J Thromb Haemost Source Type: research

Multiple risk factors and ischaemic stroke in the elderly Asian population with and without atrial fibrillation. An analysis of 425,600 Chinese individuals without prior stroke.
In conclusion, an increasing cluster of multiple cardiovascular risk factors (besides AF) contributes to a greater risk for ischaemic stroke, especially in the elderly population. If elderly and with multiple risk factors, non-AF patients may have a risk of incident ischaemic stroke that is comparable or even higher than patients with AF, suggesting that the incremental stroke risk attributable to AF is marginal in such 'high risk' patients. PMID: 26322338 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 31, 2015 Category: Hematology Authors: Guo Y, Wang H, Tian Y, Wang Y, Lip GY Tags: Thromb Haemost Source Type: research

Association of Stroke Risk Biomarkers with Stroke Symptoms: The Reasons for Geographic And Racial Differences in Stroke Cohort
ConclusionsStrong associations of stroke risk biomarkers with stroke symptoms in persons without a clinical history of cerebrovascular disease support a hypothesis that some of these stroke symptoms represent unrecognized cerebrovascular disease. Future work is needed to determine whether these biomarkers identify persons with stroke symptoms who have a particularly high stroke risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 3, 2016 Category: Hematology Authors: K. K. Landry, K. S. Alexander, N. A. Zakai, S. E. Judd, D. O. Kleindorfer, V. J. Howard, G. Howard, M. Cushman Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction.
CONCLUSIONS: ProCPU is increased in CSF during hyperacute ischemic stroke and are associated with stroke progression and outcome after 3 months, most likely due to BBB dysfunction in the hyperacute phase of ischemic stroke. This article is protected by copyright. All rights reserved. PMID: 29194929 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 1, 2017 Category: Hematology Authors: Mertens JC, Leenaerts D, Brouns R, Engelborghs S, Ieven M, De Deyn PP, Lambeir AM, Hendriks D Tags: J Thromb Haemost Source Type: research

A Nationwide Analysis of Outcomes of Stroke in Hospitalized Patients with Essential Thrombocythemia: 2006 to 2014
Conclusions:Patients with ET who are hospitalized with stroke have significantly worse outcomes. This study demonstrated that a statistically significant difference exists among different age groups of patients with ET and stoke who died during hospitalization when stratification is made using age groups and Charlson Score. This study may serve as an initial point to include new risk factors for further risk stratification. Early identification of patients at higher risk may reduce the incidence and decrease the morbidity of stroke in patients with ET.DisclosuresKota: BMS: Honoraria; Novartis: Honoraria; Xcenda: Honoraria;...
Source: Blood - November 21, 2018 Category: Hematology Authors: Ajebo, G., Badin, K., Forehand, W., Guddati, A. K., Kota, V. Tags: 634. Myeloproliferative Syndromes: Clinical: Poster III Source Type: research

ABO Blood Type and Stroke Risk: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
ConclusionBlood type AB is associated with an increased risk of stroke that is not attenuated by conventional stroke risk factors and factor VIII levels were associated with 60% of the association. While blood type AB is rare in the U.S. population, it is a significant stroke risk factor and may play an important role in stroke risk in these individuals.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 21, 2014 Category: Hematology Authors: Neil A. Zakai, Suzanne E. Judd, Kristine Alexander, Leslie A. McClure, Brett M. Kissela, George Howard, Mary Cushman Tags: Original Article ‐ Vascular Biology Source Type: research

ABO blood type and stroke risk: the REasons for Geographic And Racial Differences in Stroke Study
ConclusionBlood type AB is associated with an increased risk of stroke that is not attenuated by conventional stroke risk factors, and factor VIII levels were associated with 60% of the association. While blood type AB is rare in the US population, it is a significant stroke risk factor and may play an important role in stroke risk in these individuals.
Source: Journal of Thrombosis and Haemostasis - April 11, 2014 Category: Hematology Authors: N. A. Zakai, S. E. Judd, K. Alexander, L. A. McClure, B. M. Kissela, G. Howard, M. Cushman Tags: Original Article Source Type: research

Comorbidity and the increased mortality after hospitalization for stroke: a population-based cohort study.
CONCLUSION: Comorbidity, notably cancer and advanced renal or liver disease, increased one-year mortality after stroke beyond the combined effects expected from either disease acting alone. This article is protected by copyright. All rights reserved. PMID: 29171148 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 23, 2017 Category: Hematology Authors: Corraini P, Szépligeti SK, Henderson VW, Ording AG, Horváth-Puhó E, Sørensen HT Tags: J Thromb Haemost Source Type: research

Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood ‐brain barrier dysfunction
ConclusionsProCPU is increased in CSF during hyperacute ischemic stroke and are associated with stroke progression and outcome after 3 months, most likely due to BBB dysfunction in the hyperacute phase of ischemic stroke.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - December 1, 2017 Category: Hematology Authors: Joachim C Mertens, Dorien Leenaerts, Raf Brouns, Sebastiaan Engelborghs, Margareta Ieven, Peter P De Deyn, Anne ‐Marie Lambeir, Dirk Hendriks Tags: Brief Report – Fibrinolysis Source Type: research

Preadmission use of Glucocorticoids and Risk of Cardiovascular Events in Patients with Ischemic Stroke.
CONCLUSIONS: During the first year after ischemic stroke, current glucocorticoid use was associated with moderately increased risk of myocardial infarction and venous thromboembolism and lower risk of hemorrhagic stroke, while the risk of recurrent ischemic stroke was not affected. This article is protected by copyright. All rights reserved. PMID: 30179297 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 4, 2018 Category: Hematology Authors: Sundbøll J, Darvalics B, Horváth-Puhó E, Adelborg K, Laugesen K, Schmidt M, Henderson VW, Sørensen HT Tags: J Thromb Haemost Source Type: research

Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis
Conclusions: Our results suggest that inherited thrombophilias including FVL, PTM, PCD, and PSD are associated with an increased risk of arterial ischemic stroke, particularly in young patients. The association with FVL and PTM is stronger in the homozygous than in the heterozygous state, suggesting a potential dose-response relationship and causal role for inherited thrombophilias. The implications of these findings with respect to the evaluation and management of patients with ischemic stroke require further investigation.DisclosuresCrowther: Alnylam: Equity Ownership; Daiichi Sankyo: Membership on an entity's Board of D...
Source: Blood - November 21, 2018 Category: Hematology Authors: Chiasakul, T., De Jesus, E., Tong, J., Chen, Y., Crowther, M., Garcia, D. A., Chai-Adisaksopha, C., Messe, S. R., Cuker, A. Tags: 331. Pathophysiology of Thrombosis: Poster II Source Type: research

Stroke-induced hexokinase 2 in circulating monocytes exacerbates vascular inflammation and atheroprogression
CONCLUSIONS: Stroke-induced monocyte Hk2 upregulation is a key mechanism underlying post-stroke vascular inflammation and atheroprogression.PMID:36893911 | DOI:10.1016/j.jtha.2023.02.021
Source: Thrombosis and Haemostasis - March 9, 2023 Category: Hematology Authors: Yang Sun Lujun Zhang Yu Cao Xingsheng Li Fan Liu Xiaoxiao Cheng Jianlin Du Haitao Ran Zhigang Wang Yongyong Li Yuxing Feng Liwen Liang Wenhua Su N D Melgiri Hong Zhang Rongzhong Huang Source Type: research