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Specialty: Hematology

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Total 2753 results found since Jan 2013.

Association of coagulation factors profile with clinical outcome in patient with COVID-19 and acute stroke: A second wave cohort study
This study reported coagulation profile of COVID-19 patients with acute stroke and its association with patients' outcome.METHOD: This is a cohort-retrospective study conducted during the second wave of COVID-19, June-August 2021 in Cipto Mangunkusumo General Hospital. Inclusion criteria were adult patients with confirmed COVID-19 and diagnosed with acute stroke confirmed by radiological evidences. Exclusion criteria were COVID-19 patients with prior diagnosis of acute stroke. Coagulation factors were analyzed and presented with tables and graphs.RESULTS: A total of 33 patients included in this study with majority experien...
Source: Clinical Hemorheology and Microcirculation - July 24, 2022 Category: Hematology Authors: Al Rasyid Dinda Larastika Riyanto Salim Harris Mohammad Kurniawan Taufik Mesiano Rakhmat Hidayat Elvan Wiyarta Source Type: research

Hypercoagulability on Thromboelastography Can Predict the Functional Outcome in Patients with Acute Ischemic Stroke
CONCLUSION: A R of <5 min was a negative predictor of functional independence. Frequent HT, END, and different stroke etiologies according to the R may be the cause of poor outcome after ischemic stroke.PMID:37130549 | DOI:10.1055/a-2084-5018
Source: Thrombosis and Haemostasis - May 2, 2023 Category: Hematology Authors: Jae-Chan Ryu Jae-Han Bae Sang Hee Ha Bum Joon Kim Sang-Beom Jeon Dong-Wha Kang Sun U Kwon Jong S Kim Jun Young Chang Source Type: research

Association between polycythemia and risk of ischemic stroke in males based on the National Health Insurance Service-Health Screening Cohort
CONCLUSIONS: The risk of ischemic stroke was higher in participants with polycythemia than in those with normocythemia.PMID:37249134 | DOI:10.1080/17474086.2023.2218610
Source: Expert Review of Hematology - May 30, 2023 Category: Hematology Authors: Hyo-Sun You Sang-Jun Shin Joungyoun Kim Hee-Taik Kang Source Type: research

Association between polycythemia and risk of ischemic stroke in males based on the national health insurance service-health screening cohort
CONCLUSIONS: The risk of ischemic stroke was higher in participants with polycythemia than in those with normocythemia.PMID:37249134 | DOI:10.1080/17474086.2023.2218610
Source: Expert Review of Hematology - May 30, 2023 Category: Hematology Authors: Hyo-Sun You Sang-Jun Shin Joungyoun Kim Hee-Taik Kang Source Type: research

Sexual dimorphism in peripheral blood cell characteristics linked to recanalization success of endovascular thrombectomy in acute ischemic stroke
AbstractEndovascular thrombectomy (EVT) success to treat  acute ischemic stroke varies with factors like stroke etiology and clot composition, which can differ between sexes. We studied if sex-specific blood cell characteristics (BCCs) are related to recanalization success. We analyzed electronic health records of 333 EVT patients from a single interve ntion center, and extracted 71 BCCs from the Sapphire flow cytometry analyzer. Through Sparse Partial Least Squares Discriminant Analysis, incorporating cross-validation and stability selection, we identified BCCs associated with successful recanalization (TICI 3) in ...
Source: Journal of Thrombosis and Thrombolysis - August 18, 2023 Category: Hematology Source Type: research

The impact of atherosclerotic vascular disease in predicting stroke, thromboembolism and mortality in atrial fibrillation patients: A systematic review
ConclusionAtherosclerotic vascular disease (eg. peripheral arterial disease, complex aortic plaque and prior MI) are significant predictors of stroke, thromboembolism and mortality in subjects with AF.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - February 1, 2013 Category: Hematology Authors: Branavan Anandasundaram, Deirdre Lane, Stavros Apostolakis, Gregory Y H Lip Tags: Original Article ‐ Vascular Biology Source Type: research

The impact of atherosclerotic vascular disease in predicting a stroke, thromboembolism and mortality in atrial fibrillation patients: a systematic review
ConclusionAtherosclerotic vascular disease (e.g. peripheral arterial disease, complex aortic plaque and prior MI) are significant predictors of a stroke, thromboembolism and mortality in subjects with AF.
Source: Journal of Thrombosis and Haemostasis - May 15, 2013 Category: Hematology Authors: B. Anandasundaram, D. A. Lane, S. Apostolakis, G. Y. H. Lip Tags: Original Article Source Type: research

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.
Abstract Wild type (WT) activated protein C (APC) and cytoprotective-selective APC variants such as 3K3A-APC (<10% anticoagulant but normal cytoprotective activity) are neuroprotective in murine focal ischemic stroke models. Here we compared the neuroprotective effects of the anticoagulant-selective E149A-APC variant (>3-fold increased anticoagulant activity but defective cytoprotective activities) to those of the cytoprotective-selective 5A-APC variant (<10% anticoagulant activity). After transient distal middle cerebral artery occlusion, mice received a vehicle, E149A-APC or 5A-APC at 0.2mg/kg at 4h aft...
Source: Blood Cells, Molecules and Diseases - March 28, 2013 Category: Hematology Authors: Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV Tags: Blood Cells Mol Dis Source Type: research

Novel oral anticoagulants in secondary prevention of stroke
In patients with atrial fibrillation (AF) oral anticoagulation with vitamin-K antagonists (warfarin, phenprocoumon) is effective both for primary and secondary stroke prevention yielding a 60–70% relative reduction in stroke risk compared with placebo, as well as a mortality reduction of 26 percent. Vitamin-K antagonists have a number of well documented shortcomings. Recently the results of randomised trials for three new oral anticoagulants that do not exhibit the limitations of vitamin-K antagonists have been published. These include direct factor Xa inhibitors (rivaroxaban and apixaban) and a direct thrombin inhibitor...
Source: Best Practice and Research. Clinical Haematology - June 1, 2013 Category: Hematology Authors: H.C. Diener, J.D. Easton, G.J. Hankey, R.G. Hart Source Type: research

Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk
Abstract Stroke is one of the most disabling complications of sickle cell anemia (SCA). The molecular mechanisms leading to stroke in SCA or by which packed red blood cell (PRBC) transfusion prevents strokes are not understood. We investigated the effects of PRBC transfusion on serum biomarkers in children with SCA who were at high‐risk for stroke. Serum samples from 80 subjects were analyzed, including baseline, study exit time point and 1 year after study exit. Forty of the 80 samples were from subjects randomized to standard care and 40 from transfusion arm. Samples were assayed for levels of BDNF, sVCAM‐1, sICAM‐...
Source: American Journal of Hematology - August 31, 2013 Category: Hematology Authors: Hyacinth I. Hyacinth, Robert J. Adams, Jenifer H. Voeks, Jacqueline M. Hibbert, Beatrice E. Gee Tags: Research Article Source Type: research

Novel oral anticoagulants in secondary prevention of stroke
In patients with atrial fibrillation (AF) oral anticoagulation with vitamin-K antagonists (warfarin, phenprocoumon) is effective both for primary and secondary stroke prevention yielding a 60–70% relative reduction in stroke risk compared with placebo, as well as a mortality reduction of 26 percent. Vitamin-K antagonists have a number of well documented shortcomings. Recently the results of randomised trials for three new oral anticoagulants that do not exhibit the limitations of vitamin-K antagonists have been published. These include direct factor Xa inhibitors (rivaroxaban and apixaban) and a direct thrombin inhibitor...
Source: Best Practice and Research. Clinical Haematology - June 1, 2013 Category: Hematology Authors: H.C. Diener, J.D. Easton, G.J. Hankey, R.G. Hart Source Type: research

Sickle‐cell disease stroke throughout life: A retrospective study in an adult referral center
Abstract Strokes are one of the most severe complications of sickle‐cell disease. Most studies have been restricted to children with sickle‐cell disease. To better understand the characteristics and follow‐up of strokes occurring from childhood to adulthood, we undertook a retrospective cohort study of 69 stroke patients among the 2,875 patients consulting at the French Adult Sickle‐Cell Disease Referral Center. Between 1970 and 2008, they had experienced 104 strokes: 80 ischemic, 22 hemorrhagic and 2 intracranial sinus thromboses. Coma and/or fatal outcomes underscored the severity of strokes in sickle‐cell dise...
Source: American Journal of Hematology - November 8, 2013 Category: Hematology Authors: Antoine Gueguen, Matthieu Mahevas, Ruben Nzouakou, Hassan Hosseini, Anoosha Habibi, Dora Bachir, Pierre Brugière, François Lionnet, Jean‐Antoine Ribeil, Bertrand Godeau, Robert Girot, Vahid Ibrahima, David Calvet, Frédéric Galactéros, Pablo Bartolu Tags: Research Article Source Type: research