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Total 2753 results found since Jan 2013.

Evaluation of patients' attitudes towards stroke prevention and bleeding risk in atrial fibrillation.
In conclusion, there was a substantial amount of inter-patient variability, and often extreme differences in opinion regarding tolerance of bleeding risk in the context of stroke prevention in atrial fibrillation. These findings highlight the importance of considering patient preferences when deciding on SPAF therapy. PMID: 24337399 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 12, 2013 Category: Hematology Authors: Lahaye S, Regpala S, Lacombe S, Sharma M, Gibbens S, Ball D, Francis K Tags: Thromb Haemost Source Type: research

Stroke prevention in atrial fibrillation: An Asian perspective.
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. In 2050, it is estimated that there will be 72 million AF patients in Asia, accounting for almost 2.9 million patients suffering from AF-associated stroke. Asian AF patients share similar risk factor profiles as non-Asians, except that more Asians have a history of previous stroke. Clinical challenges are evident in the field of stroke prevention in AF, amongst Asians. Existing stroke and bleeding risk scores have not been well-validated in Asians. Asians are prone to bleeding when treated with warfarin, and the optimal internationa...
Source: Thrombosis and Haemostasis - February 6, 2014 Category: Hematology Authors: Chiang CE, Wang KL, Lip GY Tags: Thromb Haemost Source Type: research

Circulating desphospho‐uncarboxylated matrix Gla protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP concentrations, reflecting a poor vitamin K status, are associated with increased CHD or stroke risk in the general population.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 1, 2014 Category: Hematology Authors: Geertje W. Dalmeijer, Yvonne T. Schouw, Elke J. Magdeleyns, Cees Vermeer, W.M. Monique Verschuren, Jolanda M.A. Boer, Joline W.J. Beulens Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Improving prediction of recanalization in acute large‐vessel occlusive stroke
ConclusionsAcute endovascular treatment is the single most important factor promoting recanalization in acute ischemic stroke. The presence of extracranial vessel stenosis or occlusion decreases recanalization rates. In patients with intracranial occlusions, higher NIHSS score and ASPECTS and normal vigilance facilitate recanalization. Clinical use of these predictors could influence recanalization strategies in individual patients.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: P. Vanacker, D. Lambrou, A. Eskandari, P. Maeder, R. Meuli, G. Ntaios, P. Michel Tags: Original Article Source Type: research

Circulating desphospho‐uncarboxylated matrix γ‐carboxyglutamate protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP levels, reflecting poor vitamin K status, are associated with increased CHD or stroke risk in the general population.
Source: Journal of Thrombosis and Haemostasis - June 19, 2014 Category: Hematology Authors: G. W. Dalmeijer, Y. T. Schouw, E. J. Magdeleyns, C. Vermeer, W. M. M. Verschuren, J. M. A. Boer, J. W. J. Beulens Tags: Original Article Source Type: research

The clinical utility of Multiplate analyser measurement in platelet function testing following stroke and transient ischaemic attack
ConclusionThe Multiplate device gives reproducible, precise results in volunteers and stroke/TIA patients.This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - June 30, 2014 Category: Hematology Authors: Gurdeep S. Mannu, Alistair Macartney, Jonathan R. A. Lambert, Joao H. Bettencourt‐Silva, Mark Lawn, Hamish Lyall, Anthony Kneale Metcalf, John F Potter, John Wood, Allan Clark, Trevor Baglin, Phyo Kyaw Myint, Kristian M. Bowles Tags: Original Article Source Type: research

Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke
Abstract In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1 % men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 ...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Association of selenoprotein S gene polymorphism with ischemic stroke in a Chinese case–control study
Previous studies showed that selenoprotein S (SELS) was associated with a range of inflammatory markers, and its gene expression was influenced by a polymorphism in the promoter region. The genetic basis of the ischemic stroke has now been largely determined, so the aim of the study was to examine the role of SELS genetic variants in the ischemic stroke risk in a Chinese population. We conducted a case–control study with 239 ischemic stroke patients and 240 controls. Two single-nucleotide polymorphisms (SNPs) in SELS genes were analyzed for association with the risk of ischemic stroke in the Chinese Han population. No ev...
Source: Blood Coagulation and Fibrinolysis - January 30, 2015 Category: Hematology Tags: Original Articles Source Type: research

Relationship Between Red Cell Distribution Width and Stroke in Patients With Stable Chronic Heart Failure: A Propensity Score Matching Analysis
Conclusion: In conclusion, this study demonstrated that RDW may be important hematological indices for stroke in patients with HF using propensity score analysis.
Source: Clinical and Applied Thrombosis/Hemostasis - February 2, 2015 Category: Hematology Authors: Kaya, A., Isik, T., Kaya, Y., Enginyurt, O., Gunaydin, Z. Y., Iscanli, M. D., Kurt, M., Tanboga, I. H. Tags: Original Articles Source Type: research

Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanis...
Source: Journal of Hematology and Oncology - April 11, 2015 Category: Hematology Authors: Ya-Feng LiLi-Na RenGeng GuoLee CannellaValeria ChernayaSonia SamuelSu-Xuan LiuHong WangXiao-Feng Yang Source Type: research

Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study.
CONCLUSIONS: These results support the importance of contact activation pathway-dependent TG as a risk factor for ischemic stroke and indicate the importance of F12 SNPs on TG ex vivo and in vivo. This article is protected by copyright. All rights reserved. PMID: 26286125 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 19, 2015 Category: Hematology Authors: Olson NC, Butenas S, Lange LA, Lange EM, Cushman M, Jenny NS, Walston J, Souto JC, Soria JM, Chauhan G, Debette S, Longstreth WT, Seshadri S, Reiner AP, Tracy RP Tags: J Thromb Haemost Source Type: research

High mortality among children with sickle cell anemia and overt stroke who discontinue blood transfusion after transition to an adult program.
CONCLUSION: Efforts must be made to maintain adequate chronic simple or exchange blood transfusion for children with SS and stroke after transition to adult care. PMID: 26593779 [PubMed - as supplied by publisher]
Source: Transfusion - November 23, 2015 Category: Hematology Authors: McLaughlin JF, Ballas SK Tags: Transfusion Source Type: research

Acenocoumarol vs. low-dose dabigatran in real-world patients discharged after ischemic stroke
The aim of this study was to compare the efficacy of dabigatran 110 mg twice daily and acenocoumarol in patients with atrial fibrillation discharged after ischemic stroke. We prospectively studied 436 consecutive patients who were discharged after acute ischemic stroke (39.2% males, age 78.6 ± 6.7 years). Approximately 1 year after discharge, the functional status was assessed with the modified Rankin scale (mRS). Adverse outcome was defined as mRS between 2 and 6. The occurrence of ischemic stroke, myocardial infarction (MI) and death during the 1-year follow-up was also recorded. At discharge, 142 patients had atr...
Source: Blood Coagulation and Fibrinolysis - February 2, 2016 Category: Hematology Tags: Original Articles Source Type: research

Covariates of non-dipping and elevated night-time blood pressure in ischemic stroke patients: the Norwegian Stroke in the Young Study.
In conclusion, in the Norwegian Stroke in the Young Study, non-dipping BP pattern was common and associated with increased aortic stiffness. PMID: 26694634 [PubMed - as supplied by publisher]
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Haemostatic biomarkers are associated with long-term recurrent vascular events after ischaemic stroke.
In conclusion, plasma levels of haemostatic factors were associated with vascular death and coronary events, but not with recurrent stroke. Our results suggest that the predictive value of biomarkers differ by specific outcome measure and subgroup of patients. PMID: 27357914 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 29, 2016 Category: Hematology Authors: Pedersen A, Redfors P, Lundberg L, Gils A, Declerck PJ, Nilsson S, Jood K, Jern C Tags: Thromb Haemost Source Type: research