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Specialty: Hematology

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Total 2753 results found since Jan 2013.

proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke.
CONCLUSIONS: Increased serum proMMP-10 after acute ischemic stroke, associated with TNFα, is a new marker of brain damage and poor outcome. This article is protected by copyright. All rights reserved. PMID: 23742289 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 7, 2013 Category: Hematology Authors: Rodríguez JA, Sobrino T, Orbe J, Purroy A, Martínez-Vila E, Castillo J, Páramo JA Tags: J Thromb Haemost Source Type: research

Female sex as an independent risk factor for stroke in atrial fibrillation: Possible mechanisms.
The objective of this review is to describe the potential mechanisms behind the increased risk of stroke in AF associated with female sex. PMID: 24305974 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 5, 2013 Category: Hematology Authors: Cove CL, Albert CM, Andreoti F, Badimon L, Van Gelder IC, Hylek EM Tags: Thromb Haemost Source Type: research

Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.
CONCLUSIONS: Our data demonstrates that secondary microthrombosis does not occur after thrombin-induced stroke. In view of that, the pathophysiological roles of hematologic players promoting or protecting from secondary microthrombosis (such as Factor XII, von Willebrand Factor, T-cells…) deserve to be reevaluated in non-TMVO stroke models. This article is protected by copyright. All rights reserved. PMID: 24354644 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 16, 2013 Category: Hematology Authors: Gauberti M, de Lizarrondo SM, Orset C, Vivien D Tags: J Thromb Haemost Source Type: research

Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke. The Italian Project on Stroke in Young Adults (IPSYS).
In conclusion, young IS patients with FH of premature arterial thrombosis exhibit a distinct risk-factor profile, an underlying procoagulant state and have worse vascular prognosis than those with no FH of juvenile thrombotic events. PMID: 25413729 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 20, 2014 Category: Hematology Authors: Pezzini A, Grassi M, Lodigiani C, Patella R, Gandolfo C, Zini A, DeLodovici ML, Paciaroni M, Del Sette M, Toriello A, Musolino R, Calabrò RS, Bovi P, Adami A, Silvestrelli G, Sessa M, Cavallini A, Marcheselli S, Bonifati DM, Checcarelli N, Tancredi L, Ch Tags: Thromb Haemost Source Type: research

Neutrophil to Lymphocyte Ratio (NLR) and Risk of First Episode Stroke in Patients with Atrial Fibrillation: A Cohort Study
ConclusionsNLR is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 18, 2015 Category: Hematology Authors: Walid Saliba, Ofra Barnett‐Griness, Mazen Elias, Gad Rennert Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale.
Abstract Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke, given the possibility of paradoxical embolism from venous to systemic circulation. D-dimer level is used to screen venous thrombosis. We investigated the risk of embolism and mortality according to the presence of PFO and D-dimer levels in cryptogenic stroke patients. A total of 570 first-ever cryptogenic stroke patients who underwent transesophageal echocardiography were included in this study. D-dimer was assessed using latex agglutination assay during admission. The association of long-term outcomes with the presence of PFO and D-di...
Source: Thrombosis and Haemostasis - May 21, 2015 Category: Hematology Authors: Kim YD, Song D, Nam HS, Lee K, Yoo J, Hong GR, Lee HS, Nam CM, Heo JH Tags: Thromb Haemost Source Type: research

Neutrophil to lymphocyte ratio and risk of a first episode of stroke in patients with atrial fibrillation: a cohort study
ConclusionsThe neutrophil to lymphocyte ratio is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings.
Source: Journal of Thrombosis and Haemostasis - September 14, 2015 Category: Hematology Authors: W. Saliba, O. Barnett‐Griness, M. Elias, G. Rennert Tags: In Focus Source Type: research

The role of CHADS2 and CHA2DS2‐VASc scores in the prediction of stroke in individuals without atrial fibrillation: a population‐based study
ConclusionsCHADS2 and CHA2DS2‐VASc scores have a relatively high performance for stroke/TIA prediction in individuals without AF which is comparable to their performance in patients with AF.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - February 29, 2016 Category: Hematology Authors: Walid Saliba, Naomi Gronich, Ofra Barnett‐Griness, Gad Rennert Tags: Original Article Source Type: research

Hematological disorders: a commonly unrecognized cause of acute stroke.
Authors: Arboix A, Jiménez C, Massons J, Parra O, Besses C Abstract INTRODUCTION: Hematological disorders account for about 1.3% of all causes of acute stroke. This systematized review presents updated information on the implications of this category of heterogeneous diseases as a cause of stroke. AREAS COVERED: The most relevant aspects of the relationship between stroke and hematological disorders are reported. A high index of suspicion is needed in young stroke patients, patients with recurrent stroke of undetermined cause, and in patients with prior history of venous thrombosis to identify a potential hema...
Source: Expert Review of Hematology - July 3, 2016 Category: Hematology Tags: Expert Rev Hematol Source Type: research

Risk of stroke in patients with newly diagnosed multiple myeloma: a retrospective cohort study
This study includes consecutive patients 20 years and older who were newly diagnosed with symptomatic multiple myeloma at Taipei Veterans General Hospital, a tertiary medical center, between January 1, 2002 and December 31, 2014. The primary outcome was stroke development. Patients with head injuries, brain tumors, brain parenchymal invasions, or antecedent malignancies were excluded. Hazard ratios (HRs) of stroke risk factors for multiple myeloma patients were estimated by Cox proportional regression analysis. Overall, 395 patients with a median age of 70 years were investigated. In the median follow‐up period of 18 ...
Source: Hematological Oncology - August 21, 2016 Category: Hematology Authors: Gin ‐Yi Lee, Yu‐Ting Lee, Chiu‐Mei Yeh, Pei Hsu, Ting‐Wei Lin, Jyh‐Pyng Gau, Yuan‐Bin Yu, Liang‐Tsai Hsiao, Cheng‐Hwai Tzeng, Tzeon‐Jye Chiou, Jin‐Hwang Liu, Yao‐Chung Liu, Chia‐Jen Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke.
In conclusion, new strategies using exome sequence data have revealed TRPV3 as a new gene associated with cardioembolic stroke. This strategy among others might be useful in finding new genes associated with complex genetic diseases. PMID: 27604134 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 7, 2016 Category: Hematology Authors: Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, Sotolongo-Grau O, Krupinski J, Lee JM, Cruchaga C, Delgad Tags: Thromb Haemost Source Type: research

Middle Cerebral Artery Stroke in a Neonate With a Congenital Hypercoagulable Condition Following Repair of an H-type Tracheoesophageal Fistula
This report provides a concise review of the etiology and treatment of stroke and hypercoagulable states in neonates as well as presents the case of a previously undescribed complication of repair of an H-type TEF.
Source: Journal of Pediatric Hematology Oncology - September 30, 2016 Category: Hematology Tags: Original Articles Source Type: research

Clinical recovery and health-related quality of life in ischaemic stroke survivors receiving thrombolytic treatment: a 1-year follow-up study
AbstractThe aims of this study were to examine prospectively the course of neurological and functional recovery and health related quality of life (HRQoL) in ischaemic stroke patients after intravenous thrombolysis, to assess the 1-year outcome and to determine the early predictors. A group of 53 consecutive patients were assessed at admission to the acute stroke unit (T0), before their discharge (T1), and at 3 (T2) and 12 (T3) months after hospital discharge. The National Institutes of Health Stroke Scale (NIHSS), the Barthel Index (BI) and the Stroke Specific Quality of Life Scale (SSQoL) were used to evaluate stroke sev...
Source: Journal of Thrombosis and Thrombolysis - December 31, 2016 Category: Hematology Source Type: research

Thrombophilia risk is not increased in children after perinatal stroke
Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable, but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders, but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, prospective, case-control study to determine the association of specific perinatal stroke diseases with known thrombophilias. Children with idiopathic magnetic resonance imaging–cl...
Source: Blood - May 18, 2017 Category: Hematology Authors: Curtis, C., Mineyko, A., Massicotte, P., Leaker, M., Jiang, X. Y., Floer, A., Kirton, A. Tags: Pediatric Hematology, Free Research Articles, Thrombosis and Hemostasis, Vascular Biology, CME article Source Type: research

C ‐reactive protein gene polymorphism predicts the risk of thromboembolic stroke in patients with atrial fibrillation: a more than 10‐year prospective follow‐up study
ConclusionThe CRP triallelic polymorphism and the CRP level are associated with the risk of incident thromboembolic stroke in patients with AF.
Source: Journal of Thrombosis and Haemostasis - July 14, 2017 Category: Hematology Authors: S. ‐N. Chang, L.‐P. Lai, F.‐T. Chiang, J.‐L. Lin, J.‐J. Hwang, C.‐T. Tsai Tags: Original Article Source Type: research