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Procedure: SPECT

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Total 384 results found since Jan 2013.

Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage.
CONCLUSIONS: Although further research is needed, the results demonstrate the beneficial effects of HBO2 on CCI in patients after cardiac arrest, even months to years after the acute event. PMID: 26409406 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effect of local mild hypothermia on regional cerebral blood flow in patients with acute intracerebral hemorrhage assessed by 99mTc-ECD SPECT imaging.
CONCLUSION: Local mild hypothermia could significantly increase rCBF and improve clinical outcome in ICH patients as evaluated by <formula>^{99m}</formula>Tc-ECD SPECT study. PMID: 25567410 [PubMed - indexed for MEDLINE]
Source: Journal of X-Ray Science and Technology - January 25, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Changes in Binding of 123 ICLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury
This study demonstrates the applicability of [123I]CLINDE for detailed regional and quantitative assessment of glial activity in experimental models of TBI.
Source: NeuroMolecular Medicine - March 11, 2016 Category: Neurology Source Type: research

Early detection of doxorubicin-induced cardiotoxicity using the matrix metalloproteinase (MMP) targeted radiotracer, 99mTc-RP805.
Conclusions Increases in myocardial MMP activity precede clinically used echocardiographic indices for early detection of cardiotoxicity, including ejection fraction and global myocardial strain. Therefore, 99mTc-RP805 may serve as a promising approach for early detection of DOX-induced cardiotoxicity when combined with SPECT/CT imaging.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Boutagy, N., Mikush, N., Wang, X., Hawley, C., Liu, C., Sinusas, A. Tags: MTA II: Cardiovascular Basic Science Posters Source Type: research

Changes in Binding of 123 ICLINDE, a High-Affinity Translocator Protein 18  kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury
This study demonstrates the applicability of [ 123 I]CLINDE for detailed regional and quantitative assessment of glial activity in experimental models of TBI.
Source: NeuroMolecular Medicine - May 31, 2016 Category: Neurology Source Type: research

Erythropoietin Pretreatment of Transplanted Endothelial Colony-Forming Cells Enhances Recovery in a Cerebral Ischemia Model by Increasing Their Homing Ability: A SPECT/CT Study
Conclusion: Priming with erythropoietin before cell transplantation is an efficient strategy to amplify the migratory and engraftment capacities of ECFCs and their beneficial impact on BBB disruption, apoptosis, and CBF.
Source: Journal of Nuclear Medicine - October 31, 2016 Category: Nuclear Medicine Authors: Garrigue, P., Hache, G., Bennis, Y., Brige, P., Stalin, J., Pellegrini, L., Velly, L., Orlandi, F., Castaldi, E., Dignat-George, F., Sabatier, F., Guillet, B. Tags: Basic Science Investigations Source Type: research

Assessment of Hemodynamic Compromise Using Computed Tomography Perfusion in Combination with 123I-IMP Single-Photon Emission Computed Tomography without Acetazolamide Challenge Test
In this study, we investigated whether CT perfusion in combination with resting state 123I-IMP SPECT could be used instead of the acetazolamide challenge test to evaluate hemodynamic compromise in patients with atherosclerotic occlusive disease.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2016 Category: Neurology Authors: Atsumu Hashimoto, Takeshi Mikami, Katsuya Komatsu, Shouhei Noshiro, Tohru Hirano, Masahiko Wanibuchi, Nobuhiro Mikuni Source Type: research

Abnormal neurovascular coupling during status epilepticus migrainosus in Sturge-Weber syndrome
Sturge-Weber syndrome is a rare, sporadic, neurocutaneous disorder classically characterized by a facial nevus in the trigeminal distribution (port wine stain), leptomeningeal angiomatosis, and glaucoma, although intracranial changes can be present without cutaneous involvement.1 Seizures occur in up to 75% of individuals, are often associated with headache, and stroke-like episodes causing prolonged neurologic deficits are also described.1,2
Source: Neurology - January 8, 2017 Category: Neurology Authors: Sethi, M., Kowalczyk, M. A., Dalic, L. J., Archer, J. S., Jackson, G. D. Tags: Migraine, Status epilepticus, Functional neuroimaging, PET in epilepsy, SPECT in epilepsy CLINICAL/SCIENTIFIC NOTES Source Type: research

The Posterior Fossa and Foreign Accent Syndrome: Report of Two New Cases and Review of the Literature.
Abstract Foreign accent syndrome is a rare motor speech disorder that causes patients to speak their language with a non-native accent. In the neurogenic condition, the disorder develops after lesions in the language dominant hemisphere, often affecting Broca's area, the insula, the supplementary motor area and the primary motor cortex. Here, we present two new cases of FAS after posterior fossa lesions. The first case is a 44-year-old, right-handed, Dutch-speaking man who suffered motor speech disturbances and a left hemiplegia after a pontine infarction. Quantified SPECT showed a bilateral hypoperfusion in the i...
Source: Cerebellum - March 23, 2017 Category: Neuroscience Authors: Keulen S, Mariën P, van Dun K, Bastiaanse R, Manto M, Verhoeven J Tags: Cerebellum Source Type: research

Cortical Venous Redness Represents Tissue Circulation Status in Patients With Moyamoya Disease Brief Report
Conclusions—Cortical venous redness represented impaired CBF and could be a useful parameter for assessing hemodynamic changes during revascularization surgery.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Toshio Machida, Yoshinori Higuchi, Shigeki Nakano, Satoshi Ishige, Atsushi Fujikawa, Yuichi Akaogi, Junichiro Shimada, Yoichi Yoshida, Sigenori Maru, Junichi Ono Tags: Revascularization, Moyamoya Brief Reports Source Type: research

Experimental Cardiac Radiation Exposure Induces Ventricular Diastolic Dysfunction with Preserved Ejection Fraction.
CONCLUSION: Experimental cardiac radiation exposure resulted in diastolic dysfunction without reduced EF. These data provide insight into the association between cardiac radiation exposure and HFpEF risk and lend further support for the importance of inflammation related coronary microvascular compromise in HFpEF. PMID: 28550173 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 26, 2017 Category: Physiology Authors: Saiki H, Moulay G, Guenzel AJ, Liu W, Decklever T, Classic K, Pham L, Chen HH, Burnett JC, Russell SJ, Redfield MM Tags: Am J Physiol Heart Circ Physiol Source Type: research

Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the ‘watershed shift’
AbstractSuperficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard surgical treatment for moyamoya disease (MMD). The main potential complications of this treatment are cerebral hyperperfusion (CHP) syndrome and ischemia, and their managements are contradictory to each other. We retrospectively investigated the incidence of the simultaneous manifestation of CHP and infarction after surgery for MMD. Of the 162 consecutive direct revascularization surgeries performed for MMD, we encountered two adult cases (1.2%) manifesting the simultaneous occurrence of symptomatic CHP and remote infarction in...
Source: Neurosurgical Review - June 13, 2017 Category: Neurosurgery Source Type: research

Accelerated atherosclerosis in ANCA ‐associated vasculitis
ConclusionsOur study adds weight to the presence of increased atherosclerosis in AAV‐patients. The association observed between CIMT and PI‐ICA with small vessel cerebral disease, points the possible association of easy to use carotid US in predicting microvascular brain injury.
Source: Acta Neurologica Scandinavica - June 13, 2017 Category: Neurology Authors: I. Gonz ález‐Suárez, J. J. Ríos‐Blanco, J. Arpa Tags: ORIGINAL ARTICLE Source Type: research

The Posterior Fossa and Foreign Accent Syndrome: Report of Two New Cases and Review of the Literature
AbstractForeign accent syndrome is a rare motor speech disorder that causes patients to speak their language with a non-native accent. In the neurogenic condition, the disorder develops after lesions in the language dominant hemisphere, often affecting Broca ’s area, the insula, the supplementary motor area and the primary motor cortex. Here, we present two new cases of FAS after posterior fossa lesions. The first case is a 44-year-old, right-handed, Dutch-speaking man who suffered motor speech disturbances and a left hemiplegia after a pontine infarc tion. Quantified SPECT showed a bilateral hypoperfusion in the inferio...
Source: The Cerebellum - July 5, 2017 Category: Neurology Source Type: research

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction
Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but radiation specifically affects coronary microvascular endothelial cells, with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF. Global cardiac expression of the sodium-iodide symporter (NIS) was induced by cardiotropic gene (adeno-associated virus serotype 9) delivery to 5-w...
Source: AJP: Heart and Circulatory Physiology - August 11, 2017 Category: Cardiology Authors: Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C., Russell, S. J., Redfield, M. M. Tags: RESEARCH ARTICLE Source Type: research