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Total 384 results found since Jan 2013.

Amyloid Burden, Neuroinflammation, and Links to Cognitive Decline After Ischemic Stroke Topical Reviews
Source: Stroke - August 25, 2014 Category: Neurology Authors: Thiel, A., Cechetto, D. F., Heiss, W.-D., Hachinski, V., Whitehead, S. N. Tags: Behavioral Changes and Stroke, PET and SPECT, Neuroprotectors Topical Reviews Source Type: research

TSPO imaging in stroke: from animal models to human subjects
Abstract Stroke is a major health problem in developed countries and neuroinflammation has emerged over the last 2 decades as major contributor to the pathophysiological processes of brain damage following stroke. PET imaging of the translocator 18 kDa protein (TSPO) provides a unique non-invasive point of access to neuroinflammatory processes and more specifically microglial and astrocytic reaction after stroke in both animal models and patients. Here, we are reviewing both the experimental and clinical literature about in vivo TSPO PET and SPECT imaging in stroke. The studies in animal models of stroke revi...
Source: Clinical and Translational Imaging - September 30, 2015 Category: Radiology Source Type: research

Presence and extent of coronary calcified plaque evaluated by coronary computed tomographic angiography are independent predictors of ischemic stroke in patients with suspected coronary artery disease
Abstract Although ischemic stroke and coronary artery disease (CAD) share common risk factors and pathophysiology, the risk of stroke in patients with CAD remains unclear. We sought to evaluate the risk of ischemic stroke in patients with suspected CAD according to coronary computed tomographic angiography (CCTA) and single-photon emission computed tomography (SPECT) findings. Presence, severity, and extent of CAD were evaluated in 1137 patients with suspected CAD who underwent CCTA and SPECT. Primary outcome was the occurrence of ischemic stroke. During follow-up (median 26 months), ischemic stroke was obse...
Source: The International Journal of Cardiovascular Imaging - September 17, 2015 Category: Radiology Source Type: research

Obstructive carotid and/or intracranial artery disease rarely affects the incidence of haemodynamic ischaemic stroke during cardiac surgery: a study on brain perfusion single-photon emission computed tomography with acetazolamide ADULT CARDIAC
CONCLUSIONS It is unusual for CIAD to affect the incidence of haemodynamic ischaemic stroke during cardiac surgery. Brain perfusion SPECT with acetazolamide is effective for narrowing down patients at high risk of ischaemic stroke during cardiac surgery. Meanwhile, the application of brain perfusion single-photon emission tomography should be confined only to patients with obstructive CIAD because it is an expensive examination tool.
Source: European Journal of Cardio-Thoracic Surgery - October 16, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Imasaka, K.-i., Yasaka, M., Tayama, E., Tomita, Y. Tags: Cardiac - other ADULT CARDIAC Source Type: research

Case report: Rapid improvement of crossed cerebellar diaschisis after intravascular laser irradiation of blood in a case of stroke
Rationale: Crossed cerebellar diaschisis (CCD) is a poor prognostic factor after stroke because without immediate cerebral reperfusion no further improvements in the patient's condition can be achieved. We investigated the clinical effects of intravascular laser irradiation therapy (ILIB) on CCD and evaluated the therapeutic effect in the sub-acute post-stroke stage. Patient concerns: The 77-year-old male with cerebral infarction in the territory of the right anterior cerebral artery only underwent conservative treatment including hydration and aspirin in the acute post-stroke stage. Diagnosis: He was diagnosed as stroke...
Source: Medicine - January 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

PET imaging of ischemic brain stroke necrosis with novel agent 18F-Fluoroglucaric Acid
Conclusions: Results show that FGA has a potential to enable extremely sensitive and high resolution neuroimaging of brain infarcts. F-18-labeled FGA can be rapidly synthesized from ubiquitously available F-18-FDG in a simple reaction.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Houson, H., Mdzinarishvili, A., Awasthi, V. Tags: Basic Science III Source Type: research

Dabigatran vs. Aspirin for Secondary Prevention After Embolic Stroke of Undetermined Source 　- Japanese Subanalysis of the RE-SPECT ESUS Randomized Controlled Trial.
CONCLUSIONS: Dabigatran was putatively associated with a lower relative risk of recurrent stroke compared with aspirin in Japanese ESUS patients. PMID: 33132228 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 30, 2020 Category: Cardiology Authors: Toyoda K, Uchiyama S, Hagihara Y, Kuwashiro T, Mori T, Kamiyama K, Urano Y, Taniguchi A, Nozaki K, Cronin L, Grauer C, Brueckmann M, Diener HC Tags: Circ J Source Type: research

Ischemic Conditioning Is Safe and Effective for Octo- and Nonagenarians in Stroke Prevention and Treatment
The objective of this study was to evaluate the safety and effectiveness of BAIPC in reducing stroke recurrence in octo- and nonagenarian patients with SIAS. Fifty-eight patients with SIAS were enrolled in this randomized controlled prospective study for 180 consecutive days. All patients enrolled in the study received standard medical management. Patients in the BAIPC group (n = 30) underwent 5 cycles consisting of bilateral arm ischemia followed by reperfusion for 5 min each twice daily. Those in the control group (n = 28) underwent sham-BAIPC twice daily. Blood pressure, heart rate, local skin status, plasma m...
Source: Neurotherapeutics - May 9, 2015 Category: Neurology Source Type: research

PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2- 18 FFluoro- d -Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke
ConclusionsAccumulation of FGA correlated well with the perfusion defect and inflammatory injury. As a PET agent, FGA has potential to image infarcted core in the brain stroke injury with high sensitivity, resolution, and specificity.
Source: Molecular Imaging and Biology - June 15, 2020 Category: Molecular Biology Source Type: research

Aphasia Induced by Infratentorial Ischemic Stroke: Two Case Reports
Aphasia induced by an infratentorial stroke has rarely been reported, and its mechanism has not been fully identified. We evaluated two individuals who had been admitted to Saiseikai Kumamoto Hospital in Kumamoto, Japan, due to acute ischemic stroke in order to determine whether their aphasia was induced by an infratentorial stroke. The first patient, a 59-year-old man with a history of left parietal embolic stroke with very mild sequelae of anomia, developed Wernicke’s aphasia, nonfluent speech, and right limb ataxia as a result of the stroke. The second patient, a 76-year-old woman with a history of chronic renal failu...
Source: Cognitive and Behavioral Neurology - June 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Regional cerebral blood flow following single‐dose and continuous‐dose tadalafil after stroke
ConclusionTadalafil administration after cerebral stroke may be associated with diminished blood flow to areas adjacent to the stroke. The alterations in perfusion suggest a need for caution in prescribing tadalafil to patients with a history of stroke, especially with continuous administration that may impose constant stress on the cerebral circulation.
Source: Acta Neurologica Scandinavica - September 10, 2014 Category: Neurology Authors: M. Lorberboym, E. Makhline, Y. Lampl Tags: Original Article Source Type: research

Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke.
Abstract The present study was designed to evaluate the beneficial effects of Withania somnifera (WS) pre-supplementation on middle cerebral artery occlusion (MCAO) model of ischemic stroke. Ischemic stroke was induced in the rats by inserting intraluminal suture for 90 min, followed by reperfusion injury for 24 h. The animals were assessed for locomotor functions (by neurological deficit scores, narrow beam walk and rotarod test), cognitive and anxiety-like behavioural functions (by morris water maze and elevated plus maze test). MCAO animals showed significant impairment in locomotor and cognitive functions. N...
Source: Cellular and Molecular Neurobiology - December 30, 2015 Category: Cytology Authors: Sood A, Kumar A, Dhawan DK, Sandhir R Tags: Cell Mol Neurobiol Source Type: research

Detection of Crossed Cerebellar Diaschisis by Intravoxel Incoherent Motion MR Imaging in Subacute Ischemic Stroke.
Abstract Intravoxel incoherent motion has received extensive attention in brain studies for its potential as a non-invasive magnetic resonance perfusion method. However, studies on intravoxel incoherent motion imaging and crossed cerebellar diaschisis detection are relatively scarce. The aim of our study was to evaluate the feasibility of using intravoxel incoherent motion imaging in crossed cerebellar diaschisis diagnosis in subacute ischemic stroke patients by comparing results from intravoxel incoherent motion imaging, single-photon emission computed tomography, and arterial spin-labeling perfusion methods. In ...
Source: Cell Transplantation - June 13, 2019 Category: Cytology Authors: Wang J, Suo S, Zu J, Zhu W, Pan L, Song S, Li Y, Li L, Chen Z, Xu J Tags: Cell Transplant Source Type: research

Examining the evidence for PFO closure and novel oral anticoagulants for treatment of cryptogenic stroke.
Authors: Khan R Abstract Introduction: There has been considerable study assessing the treatment of cryptogenic stroke (CS) recently. This review examines the role of patent foramen ovale (PFO) closure in CS, while also discussing the evidence for alternative medical therapies in disease treatment.Areas Covered: PFO closure for treatment of CS has been assessed in 6 randomized controlled trials (RCTs). This review summarizes the background, results and limitations of these trials. Methodological and treatment-related differences in RCTs provide potential explanations for the discordance in outcomes observed between...
Source: Expert Review of Cardiovascular Therapy - February 23, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Impact of Co-morbidity on the Risk of First-Time Myocardial Infarction, Stroke, or Death After Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
In conclusion, independently of co-morbidity level, an abnormal SPECT MPI scan was associated with an increased 10-year risk of myocardial infarction and all-cause death but not stroke.
Source: The American Journal of Cardiology - June 9, 2014 Category: Cardiology Authors: Astrid Blicher Schelde, Morten Schmidt, Morten Madsen, Karin Lottrup Petersen, Søren Steen Nielsen, Jørgen Frøkiær, Henrik Toft Sørensen, Christian Fynbo Christiansen Tags: Coronary Artery Disease Source Type: research