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Total 384 results found since Jan 2013.

Monitoring Neuroprotective Effects Using Positron Emission Tomography With 11CITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor Basic Sciences
Conclusions— [11C]ITMM-PET may be a useful technique for characterizing the change in mGlu1 level during the occurrence and progression of neuronal damage and for evaluating the neuroprotective effects of drugs after ischemia.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Yui, J., Xie, L., Fujinaga, M., Yamasaki, T., Hatori, A., Kumata, K., Nengaki, N., Zhang, M.-R. Tags: PET and SPECT Basic Sciences Source Type: research

Arterial Spin-Labeling Magnetic Resonance Imaging After Revascularization of Moyamoya Disease
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is a technique for depicting cerebral perfusion without contrast medium. The purpose of this study was to determine whether ASL can be used to detect hyperperfusion after revascularization for moyamoya disease as effectively as N-isopropyl-[123I]β-iodoamphetamine (123I-IMP) single-photon emission computed tomography (SPECT). Fifteen consecutive patients with moyamoya disease were included in the study. All patients underwent surgical revascularization. Postoperatively, regional cerebral blood flow (rCBF) was measured by flow-sensitive alternating inversion reco...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2012 Category: Neurology Authors: Toshiya Sugino, Takeshi Mikami, Kei Miyata, Kengo Suzuki, Kiyohiro Houkin, Nobuhiro Mikuni Tags: Original Articles Source Type: research

Reversible cerebral vasoconstriction syndrome associated with subarachnoid hemorrhage triggered by hydroxyzine pamoate
Reversible cerebral vasoconstriction syndrome (RCVS) is a disease of unknown etiology characterized by sudden headaches with or without additional neurologic deficits. RCVS has been documented in association with ischemic stroke and convexity subarachnoid hemorrhage (SAH) , but there are no reports of RCVS associated with SAH in conjunction with hydroxyzine pamoate treatment. Therefore, this is the first case of RCVS associated with SAH and hydroxyzine pamoate followed-up with N-isopropyl[123I]-p-iodoamphetamine single photon emission computed tomography-cerebral blood flow (IMP-SPECT-CBF) imaging and 3.0T magnetic resonan...
Source: Clinical Neurology and Neurosurgery - June 14, 2013 Category: Neurosurgery Authors: Fumihiro Matano, Yasuo Murai, Koji Adachi, Kenta Koketsu, Takayuki Kitamura, Akira Teramoto, Seiji Okubo, Yasuo Katayama, Tetsuro Sekine, Ryo Takagi, Shinichiro Kumita Tags: Case reports Source Type: research

Systematic review of the diagnostic utility of spect imaging in dementia
Conclusion SPECT does have a diagnostic value, particularly in differentiating Alzheimer's disease from frontotemporal dementia and normal controls, however SPECT should not be used in isolation, rather it should be interpreted together with clinical data, neuropsychological assessment and structural brain imaging as an adjunctive diagnostic tool.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Yeo, J. M., Lim, X., Khan, Z., Pal, S. Tags: Dementia, Drugs: CNS (not psychiatric), Neuroimaging, Stroke, Memory disorders (psychiatry), Psychiatry of old age, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), Lo Source Type: research

Cerebral hemodynamic benefits after carotid artery stenting in patients with near occlusion
Conclusions: Before CAS, patients with NO were more hemodynamically compromised than those with severe stenosis without NO. After CAS, significant cerebral hemodynamic improvement and normalization occurred long-term. Thus, from a hemodynamic perspective, CAS was effective in patients with NO.
Source: Journal of Vascular Surgery - July 26, 2013 Category: Surgery Authors: Fumiaki Oka, Hideyuki Ishihara, Shoichi Kato, Takayuki Oku, Akiko Yamane, Ichiro Kunitugu, Michiyasu Suzuki Tags: Clinical research studies Source Type: research

Signal Intensity Changes for the Middle Cerebral Artery on 3-Dimensional Time-of-flight Magnetic Resonance Angiography Indicate Acute Hemodynamic Changes after Carotid Endarterectomy
In this study, we aimed to evaluate whether 3D-TOF-MRA could be used as an alternative to single-photon emission computed tomography (SPECT) for assessing the increase in the regional cerebral blood flow (rCBF) after carotid endarterectomy (CEA). To do this, we compared the SI of the middle cerebral artery (MCA) on magnetic resonance angiography (MRA) and the rCBF on SPECT.Methods: We enrolled 30 patients with internal carotid artery stenosis. SPECT and MRA were performed before and 3-4 days after CEA. rCBF was assessed using SPECT, and the SI of the MCA was assessed using single-slab 3D-TOF-MRA. Regions of interest were...
Source: Journal of Stroke and Cerebrovascular Diseases - July 1, 2013 Category: Neurology Authors: Kimitoshi Sato, Akira Kurata, Hidehiro Oka, Shinichi Kan, Yusuke Inoue, Yuji Asano, Kiyotaka Fujii Tags: Original Articles Source Type: research

123I-IMP-SPECT in a Patient with Cerebral Proliferative Angiopathy: A Case Report
We describe cerebral perfusion abnormalities in a patient with CPA by using N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography (123I-IMP-SPECT) and perfusion-weighted magnetic resonance imaging. The patient, a 13-year-old boy, had reversible focal neurological deficits unrelated to cerebral hemorrhage. 123I-IMP-SPECT at resting state showed preserved uptake within the vascular lesion, yet lower uptake in the area adjacent to the lesion. In addition, acetazolamide-stressed 123I-IMP-SPECT exhibited severely impaired cerebrovascular reactivity over the affected hemisphere, suggesting that his foca...
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Tomomi Kimiwada, Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga Tags: Case Reports Source Type: research

A Case of Nonconvulsive Status Epilepticus with a Reversible Contralateral Cerebellar Lesion: Temporal Changes in Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography Finding
A 67-year-old woman was brought to our institution because of unconsciousness. Clinical and electrophysiological findings lead us to diagnose her with nonconvulsive status epilepticus. Initial magnetic resonance imaging revealed hyperintensity in the left cerebral cortex and the right cerebellum on diffusion-weighted image and fluid-attenuated inversion recovery (FLAIR). Single-photon emission computed tomography showed increased blood flow in the left frontal cerebrum but not in the right cerebellum. The hyperintensity in the left cerebrum on the follow-up FLAIR was still present. The contralateral cerebellum remained und...
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2013 Category: Neurology Authors: Yasuko Ohe, Takeshi Hayashi, Ichiro Deguchi, Takuya Fukuoka, Hajime Maruyama, Yuji Kato, Norio Tanahashi Tags: Case Reports Source Type: research

Letter by Mugikura and Takahashi Regarding Article, "Perfusion Characteristics of Moyamoya Disease: An Anatomically and Clinically Oriented Analysis and Comparison" Letters to the Editor
Source: Stroke - February 24, 2014 Category: Neurology Authors: Mugikura, S., Takahashi, S. Tags: Brain Circulation and Metabolism, Angiography, Computerized tomography and Magnetic Resonance Imaging, PET and SPECT Letters to the Editor Source Type: research

Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain After Intra-arterial Infusion in Rats.
Abstract Intra-arterial (i.a.) delivery of bone marrow-derived mesenchymal stem cells (BMMSCs) has shown potential as a minimally invasive therapeutic approach for stroke. The aim of the present study was to determine the whole-body biodistribution and clearance of technetium-99m ((99m)Tc)-labeled rat and human BMMSCs after i.a. delivery in a rat model of transient middle cerebral artery occlusion (MCAO) using single photon emission computed tomography (SPECT). Our hypothesis was that xenotransplantation has a major impact upon the behavior of cells. Male RccHan:Wistar rats were subjected to sham-operation or MCAO...
Source: Cell Transplantation - March 3, 2014 Category: Cytology Authors: Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J Tags: Cell Transplant Source Type: research

Retrosplenial Amnesia without Topographic Disorientation Caused by a Lesion in the Nondominant Hemisphere
We report the case of a 68-year-old right-handed man who was admitted to our hospital because of sudden onset of headache. On admission, he presented with left homonymous hemianopsia, disorientation, and recent memory disturbance; however, he had normal remote memory and digit span. He was able to recall the room layout of his house and describe the route from the nearest station to his home on a map. However, at the hospital, he sometimes lost his way because of amnesia. Computed tomography (CT) and magnetic resonance imaging revealed a subcortical hematoma in the right occipital forceps and the parietal lobe, involving t...
Source: Journal of Stroke and Cerebrovascular Diseases - April 22, 2013 Category: Neurology Authors: Shinichiro Maeshima, Aiko Osawa, Fumitaka Yamane, Tomoyuki Yoshihara, Ryuzaburo Kanazawa, Shoichiro Ishihara Tags: Original Articles Source Type: research

Posterior Circulation Hyperperfusion Syndrome after Superficial Temporal Artery–Superior Cerebellar Artery Bypass for Vertebral Artery Dissection
We report the first case of posterior circulation hyperperfusion syndrome after STA–SCA bypass and provide a review of the relevant literature.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2013 Category: Neurology Authors: Kenji Fukuda, Hiroshi Abe, Tetsuya Ueba, Masakazu Okawa, Toshio Higashi, Tooru Inoue Tags: Case Reports Source Type: research

Combined Treatment of Methylprednisolone Pulse and Memantine Hydrochloride Prompts Recovery from Neurological Dysfunction and Cerebral Hypoperfusion in Carbon Monoxide Poisoning: A Case Report
A 49-year-old healthy man developed sudden unconsciousness under inadequate ventilation. Blood gas analysis showed carboxyhemoglobin of 7.3%. After normobaric oxygen therapy, he recovered completely 7 days later. At 3 weeks after carbon monoxide (CO) exposures, memory and gait disturbances appeared. Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. Brain fluid-attenuated inversion recovery imaging disclosed symmetric hypointense lesions in the thalamus and the globus pallidus, and hyperintense lesions in the cerebral w...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Konosuke Iwamoto, Ken Ikeda, Sunao Mizumura, Kazuhiro Tachiki, Masaru Yanagihashi, Yasuo Iwasaki Tags: Case Reports Source Type: research

Neurocognitive Improvement After Carotid Artery Stenting in Patients With Chronic Internal Carotid Artery Occlusion: A Prospective, Controlled, Single-Center Study
Symptomatic internal carotid artery (ICA) occlusion with hemodynamic impairment remains a dismal disease when untreated. In this prospective, single-center, controlled study, we investigated the feasibility, safety, and long-term outcome of stenting by endovascular recanalization for patients with chronic ICA occlusion. Forty patients with symptomatic chronically occluded ICA were assigned to receive endovascular recanalization (group A, n = 18) or conservative management (group B, n = 22). The primary end point was 100% complete recanalization of the primary occlusion at 60 minutes, and secondary end points were improveme...
Source: Vascular and Endovascular Surgery - April 11, 2014 Category: Surgery Authors: Fan, Y.-L., Wan, J.-Q., Zhou, Z.-W., Chen, L., Wang, Y., Yao, Q., Jiang, J.-Y. Tags: Articles Source Type: research

Cerebral Blood Flow in Patients With Peritoneal Dialysis by an Easy Z‐Score Imaging System for Brain Perfusion Single‐Photon Emission Tomography
In conclusion, all PD patients in the present study had decreased rCBF irrespective of MMSE scores.
Source: Therapeutic Apheresis and Dialysis - June 26, 2014 Category: Hematology Authors: Rei Isshiki, Shuzo Kobayashi, Masao Iwagami, Daimu Tsutumi, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Takayasu Ohtake, Sumi Hidaka Tags: Original Article Source Type: research