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Condition: Spinal Cord Injury

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Total 1255 results found since Jan 2013.

Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury
AbstractSpinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI. Ferroptosis has been revealed to be associated with diverse diseases including stroke, cancer, and kidney degeneration. Ferrostatin-1, a potent inhibitor of ferroptosis, has been illustrated to curb ferroptosis in neurons, subsequently improving functional recovery after traumatic brain injury (TBI) and SCI. However, the role...
Source: Molecular Neurobiology - October 12, 2021 Category: Neurology Source Type: research

Effects of task complexity or rate of motor imagery on motor learning in healthy young adults
ConclusionThis study supports the use of higher rates (75%) of motor imagery to improve motor learning. Additionally, the practice of a complex task demonstrated better motor learning in healthy young adults. Future longitudinal studies should validate these results in different patient's population such as stroke, spinal cord injury, and Parkinson's disease.
Source: Brain and Behavior - October 6, 2021 Category: Neurology Authors: Nargis Heena, Nayeem U. Zia, Stuti Sehgal, Shahnawaz Anwer, Ahmad Alghadir, Heng Li Tags: ORIGINAL RESEARCH Source Type: research

Molecules, Vol. 26, Pages 5985: The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective
-Sánchez Neurodegenerative diseases (NDDs) are one of the leading causes of death and disability in humans. From a mechanistic perspective, the complexity of pathophysiological mechanisms contributes to NDDs. Therefore, there is an urgency to provide novel multi-target agents towards the simultaneous modulation of dysregulated pathways against NDDs. Besides, their lack of effectiveness and associated side effects have contributed to the lack of conventional therapies as suitable therapeutic agents. Prevailing reports have introduced plant secondary metabolites as promising multi-target agents in combating NDDs. Polyda...
Source: Molecules - October 2, 2021 Category: Chemistry Authors: Sajad Fakhri Mohammad Mehdi Gravandi Sadaf Abdian Esra K üpeli Akkol Mohammad Hosein Farzaei Eduardo Sobarzo-S ánchez Tags: Review Source Type: research

Assessment of Longitudinal Changes in Manual Wheelchair Handrim Forces and Stroke Patterns in Children with Spinal Cord Injury
To identify changes in handrim kinetics and propulsive stroke patterns over time in pediatric manual wheelchair users.
Source: Archives of Physical Medicine and Rehabilitation - September 28, 2021 Category: Rehabilitation Authors: Samantha Schwartz, Alyssa Schnorenberg, Paige Aschenbrener, Lawrence Vogel, Brooke Slavens Tags: Research Poster 1710081 Source Type: research

Contrast agents for photoacoustic imaging: a review of stem cell tracking
Stem Cell Res Ther. 2021 Sep 25;12(1):511. doi: 10.1186/s13287-021-02576-3.ABSTRACTWith the advent of stem cell therapy for spinal cord injuries, stroke, burns, macular degeneration, heart diseases, diabetes, rheumatoid arthritis and osteoarthritis; the need to track the survival, migration pathways, spatial destination and differentiation of transplanted stem cells in a clinical setting has gained increased relevance. Indeed, getting regulatory approval to use these therapies in the clinic depends on biodistribution studies. Although optoacoustic imaging (OAI) or photoacoustic imaging can detect functional information of ...
Source: Cell Research - September 26, 2021 Category: Cytology Authors: Soorya James Kai Neuhaus Mary Murphy Martin Leahy Source Type: research

Transcranial Direct Current Stimulation for the Management of Neuropathic Pain: A Narrative Review
CONCLUSION: The results of the included studies suggest that tDCS may be beneficial in treating patients with NP due to stroke, spinal cord injury, multiple sclerosis, and trigeminal neuralgia. Further studies are recommended to validate the efficacy of tDCS in treating other types of NPs.PMID:34554695
Source: Pain Physician - September 23, 2021 Category: Anesthesiology Authors: Seoyon Yang Min Cheol Chang Source Type: research

The impact of upper limb spasticity-correcting surgery on the everyday life of patients with disabling spasticity: a qualitative analysis
CONCLUSIONS: The participants experienced improvements in their everyday lives, including body functions, activities, social life, and psychological well-being. The benefits derived from surgery made activities easier, increased occupational performance, allowed patients regain their roles and interpersonal interactions, and enhanced their psychological well-being.Implications for rehabilitationSpasticity-correcting surgery benefits patients by improving bodily functions, which in turn, enable gains in activities, social life, and psychological well-being.Patients' experiences of increased body functions, such as enhanced ...
Source: Disability and Rehabilitation - September 9, 2021 Category: Rehabilitation Authors: Therese Ramstr öm Lina Bunketorp-K äll Johanna Wangdell Source Type: research

Incidence, prevalence and disability associated with neurological disorders in Italy between 1990 and 2019: an analysis based on the Global Burden of Disease Study 2019
ConclusionsThe increase in YLDs associated with neurological conditions is mostly due to population ageing and growth: nevertheless, lived disability and, as a consequence, impact on health systems has increased. Actions are needed to improve outcome and mitigate disability associated with neurological conditions, spanning among diagnosis, treatment, care pathways and workplace interventions.
Source: Journal of Neurology - September 8, 2021 Category: Neurology Source Type: research

Efficacy of wrist robot-aided orthopedic rehabilitation: a randomized controlled trial
In recent years, many studies focused on the use of robotic devices for both the assessment and the neuro-motor reeducation of upper limb in subjects after stroke, spinal cord injuries or affected by neurologi...
Source: Journal of NeuroEngineering and Rehabilitation - August 31, 2021 Category: Rehabilitation Authors: Giulia Aurora Albanese, Elisa Taglione, Cecilia Gasparini, Sara Grandi, Foebe Pettinelli, Claudio Sardelli, Paolo Catitti, Giulio Sandini, Lorenzo Masia and Jacopo Zenzeri Tags: Research Source Type: research

Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats
CONCLUSION: Using a preclinical SCI model of OH, we demonstrate that complete high thoracic SCI impairs the cardiac response to OH and disrupts dynamic cerebral autoregulation.PMID:34448635 | DOI:10.1152/ajpheart.00239.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 27, 2021 Category: Physiology Authors: Brian D Hayes Mary Pauline Mona Fossey Malihe-Sadat Poormasjedi-Meibod Erin Erskine Jan Elaine Soriano Berkeley Scott Ryan Rosentreter David J Granville Aaron A Phillips Christopher R West Source Type: research

A Prognostic Factor for Prolonged Mechanical VentilatorDependent Respiratory Failure after Cervical Spinal Cord Injury : Maximal Canal Compromise on Magnetic Resonance Imaging
CONCLUSION: As a method of predicting which patients would be able to undergo weaning from MV early, the MCC is a valid factor. If the MCC exceeds 51.4%, prognosis of respiratory function becomes poor and the probability of MVDC is increased.PMID:34420278 | DOI:10.3340/jkns.2020.0346
Source: Journal of Korean Neurosurgical Society - August 23, 2021 Category: Neurosurgery Authors: Subum Lee Sung Woo Roh Sang Ryong Jeon Jin Hoon Park Kyoung-Tae Kim Young-Seok Lee Dae-Chul Cho Source Type: research