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Condition: Spinal Cord Injury

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Total 1255 results found since Jan 2013.

Peripherally delivered Adeno-associated viral vectors for spinal cord injury repair
In conclusion, in the future, minimally invasive administration of AAVs may improve recovery after SCI with minimal side effects.PMID:34896114 | DOI:10.1016/j.expneurol.2021.113945
Source: Experimental Neurology - December 13, 2021 Category: Neurology Authors: Jared D Sydney-Smith Aline B Spejo Philippa M Warren Lawrence D F Moon Source Type: research

Bone marrow mesenchymal stem cell derived exosomal miR-455-5p protects against spinal cord ischemia reperfusion injury
Tissue Cell. 2021 Nov 22;74:101678. doi: 10.1016/j.tice.2021.101678. Online ahead of print.ABSTRACTAt present, much more studies have focused on the therapeutic effect of exosome-delivered microRNAs on diseases. Previous study has shown that miR-455-5p is downregulated in ischemic stroke, but little is known about the role of exosome-delivered miR-455-5p in spinal cord ischemia reperfusion (SCIR) injury. Herein, we isolated exosomes from bone marrow mesenchymal stem cells (BMSCs) transfected with lentivirus vectors containing miR-455-5p. SCIR rat model was established after the intrathecal injection of exosomes containing ...
Source: Tissue and Cell - November 25, 2021 Category: Cytology Authors: Bing Liu Wenjun Zheng Li Dai Shengjie Fu Enyi Shi Source Type: research

Measurement Properties of the Full and Brief Version of the Work Rehabilitation Questionnaire in Persons with Physical Disabilities
Conclusions The WORQ showed good internal consistency and test –retest reliability. Agreement demonstrated large score differences are needed to indicate change beyond random chance at individual level, whereas small changes are sufficient at group level. Criterion validity of the WORQ-FULL versus the WORQ-BRIEF was supported, however, agreement demonstrated moderate to large score differences are needed to indicate change beyond random chance at individual level, whereas small changes are sufficient at group level. This indicates the WORQ-FULL and WORQ-BRIEF are better not used interchangeably. Correlation analyses prov...
Source: Journal of Occupational Rehabilitation - November 22, 2021 Category: Rehabilitation Source Type: research

Savings of loss-of-life expectancy and lifetime medical costs from prevention of spinal cord injuries: analysis of nationwide data followed for 17 years
Conclusions We conclude that quadriplegia has a higher impact on medical costs than paraplegia, and MV-related SCI has a higher impact on loss-of-LE than fall-related SCI. We recommend comprehensive SCI prevention be established, including infrastructures of construction and transportation.
Source: Injury Prevention - November 22, 2021 Category: Accident Prevention Authors: Lien, W.-C., Wang, W.-M., Wang, F., Wang, J.-D. Tags: Original research Source Type: research

Family caregiving research: Reflecting on the past to inform the future
CONCLUSIONS: Family caregivers make an important contribution to the health and wellbeing of individuals with spinal and other neurological conditions. Ultimately, system changes, like family centered care, may be best suited to meet the complex needs of this heterogeneous group of caregivers.PMID:34779725 | DOI:10.1080/10790268.2021.1970883
Source: Journal of Spinal Cord Medicine - November 15, 2021 Category: Orthopaedics Authors: Jill I Cameron Source Type: research

Comparing preference related to comfort in torque-matched muscle contractions between two different types of functional electrical stimulation pulses in able-bodied participants
CONCLUSION: Reducing discomfort during FES may help in generating stronger and more clinically useful contractions, increasing accessibility of FES therapy to include individuals with low tolerance to FES.PMID:34779723 | DOI:10.1080/10790268.2021.1970882
Source: Journal of Spinal Cord Medicine - November 15, 2021 Category: Orthopaedics Authors: Martha G Garcia-Garcia Lazar I Jovanovic Milos R Popovic Source Type: research

Clinical application of stem cell therapy in neurogenic bladder: a systematic review and meta-analysis
ConclusionAlthough most clinical trials provide evidence of the safety and effectiveness of MSCs on the management of NGB, the meta-analysis results did not show a significant improvement; however, the interpretation of study results is difficult because of the lack of placebo controls.
Source: International Urogynecology Journal - November 12, 2021 Category: OBGYN Source Type: research

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