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Total 304 results found since Jan 2013.
Arsenic, polycyclic aromatic hydrocarbons, and metal exposure and risk assessment of stroke
This study aimed to assess different arsenic species, including total arsenic; two types of organic arsenic, i.e., arsenobetaine and arsenocholine; four types of inorganic arsenic, i.e., arsenic acid, arsenous acid, dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA); six types of urinary polycyclic aromatic hydrocarbon (PAH) compounds, i.e., 1-hydroxynaphthalene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 2-hydroxynaphthalene, 2-hydroxyfluorene, and 3-hydroxyfluorene; and fourteen types of metals from urine specimen, i.e., manganese, cadmium, lead, mercury, barium, cobalt, strontium, molybdenum, cesium, thallium, an...
Source: Environmental Science and Pollution Research International - July 6, 2023 Category: Environmental Health Authors: Humairat H Rahman Sifat Parveen Sheikh Stuart H Munson-McGee Source Type: research
Progress in Borneol Intervention for Ischemic Stroke: A Systematic Review
Conclusion: Borneol prevents neuronal injury after cerebral ischemia via multiple action mechanisms, and it can mobilize endogenous nutritional factors to hasten repair and regeneration of brain tissue. Because the neuroprotective effects of borneol are mediated by various therapeutic factors, deficiency caused by a single-target drug is avoided. Besides, borneol promotes other drugs to pass through the blood-brain barrier to exert synergistic therapeutic effects.
Source: Frontiers in Pharmacology - May 4, 2021 Category: Drugs & Pharmacology Source Type: research
Epigenetics and stroke: role of DNA methylation and effect of aging on blood-brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptional profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven days poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in genes en...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Chelsea Phillips Svetlana Stamatovic Richard Keep Anuska Andjelkovic Source Type: research
Epigenetics and stroke: role of DNA methylation and effect of aging on blood –brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptiona l profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven day s poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11,287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in gen...
Source: Fluids and Barriers of the CNS - February 28, 2023 Category: Neuroscience Source Type: research
Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes
Ischemic stroke is a major cause of premature death and chronic disability worldwide, and individual variation in functional outcome is strongly influenced by genetic factors. Neuroendocrine signaling by the hypothalamic −hypophyseal−thyroid axis is a critical regulator of post-stroke pathogenesis, suggesting that allelic variants in thyroid hormone (TH) signaling can influence stroke outcome.Aim: To examine associations between acute ischemic stroke (AIS) outcome and allelic variants of the TH metabolizing enzy mes deiodinase type 1–3 (DIO1–3) and membrane transporting organic anion polypeptide C1 (OATP1C1).
Source: Journal of the Neurological Sciences - September 10, 2019 Category: Neurology Authors: Saulius Taroza, Daiva Rastenyt ė, Aurelija Podlipskytė, Vaiva Patamsytė, Narseta Mickuvienė Source Type: research
Stroke in supplementary motor area mimicking functional disorder: a case report
We report a 59-year-old man with previous history for myocardial infarction, referred to emergency room with an acute dense right-side hemiplegia, positive Hoover sign, asymmetrical Babinski responses and intermittent ability to move his arm in some specific reflex actions despite plegia. Since brain computed tomography scan was unremarkable we could not be sure whether his symptoms were organic or functional until a diffusion weighted imaging of magnetic resonance imaging elucidated the situation. To our knowledge, there is only one case report in the literature prior to ours, presenting a supplementary motor area stroke ...
Source: Journal of Neurology - September 28, 2019 Category: Neurology Source Type: research
Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats
Exp Neurol. 2022 Jul 26:114181. doi: 10.1016/j.expneurol.2022.114181. Online ahead of print.ABSTRACTDrug discovery and development for stroke is challenging as evidenced by few drugs that have advanced beyond a Phase III clinical trial. Memantine is a N-methyl-d-aspartate (NMDA) receptor antagonist that has been shown to be neuroprotective in various preclinical studies. We have identified an endogenous BBB uptake transport system for memantine: organic cation transporters 1 and 2 (Oct1/Oct2). Our goal was to evaluate Oct1/Oct2 as a required BBB mechanism for memantine neuroprotective effects. Male Sprague-Dawley rats (200...
Source: Experimental Neurology - July 29, 2022 Category: Neurology Authors: Joshua A Stanton Erica I Williams Robert D Betterton Thomas P Davis Patrick T Ronaldson Source Type: research
A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes
Adv Sci (Weinh). 2023 May 2:e2206854. doi: 10.1002/advs.202206854. Online ahead of print.ABSTRACTFollowing stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging to treat stroke through scavenging excessive ROS. However, most of nanozymes cannot efficiently scavenge ROS in neuronal cytosol and mitochondria, due to low-uptake abilities of neurons and barriers of organelle membranes, significantly limiting nanozymes' neuroprotective effects. To overcome this limitation, a man...
Source: Adv Data - May 2, 2023 Category: Epidemiology Authors: Jian Wang Yang Wang Xiakeerzhati Xiaohalati Qiangfei Su Jingwei Liu Bo Cai Wen Yang Zheng Wang Lin Wang Source Type: research
Analysis of psychiatric consultations in the department of neurology and stroke unit: diagnosis and therapy
CONCLUSIONS: Patients in the department of neurology and stroke unit underwent a psychiatric consultation most frequently. Optimizing the care of aneurological patient is related to close cooperation of a neurologist and a psychiatrist, as well as developing and updating common positions for the management of selected disease entities.PMID:34997738 | DOI:10.12740/PP/OnlineFirst/116320
Source: Psychiatria Polska - January 8, 2022 Category: Psychiatry Authors: Tomasz Chmiela Pawe ł Piekarz Beata Łabuz-Roszak Anna Warchala Ewa Krzystanek Agnieszka Gorzkowska Source Type: research
