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Magnetically and Electrically Responsive Soft Actuator Derived from Ferromagnetic Bimetallic Organic Framework
In this work, a novel bimetallic metal-organic frameworks (MOFs) (NdFeMOFs) is developed via solvothermal synthesis method. The NdFeMOFs  shows superior electrochemical and magnetic properties after calcination, which enable their use as a dual responsive material under the external electrical and magnetic stimuli. The ability to accomplish the complex motions at ultralow input voltages and magnetic fields makes them a promising mat erial for robotic applications. With the developed electroactive and magnetoactive soft actuator, walking movement of a starfish robot is demonstrated. AbstractThe advancement in smart devices...
Source: Small - March 13, 2023 Category: Nanotechnology Authors: Pradeep Sambyal, Manmatha Mahato, Ashhad Kamal Taseer, Hyunjoon Yoo, Mousumi Garai, Van Hiep Nguyen, Syed Sheraz Ali, Il ‐Kwon Oh Tags: Research Article Source Type: research

Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity
Acori Tatarinowii Rhizoma (ATR, Shi Chang Pu in Chinese), a natural product with multiple targets in various diseases. This review provides the comprehensive summary of the chemical composition, pharmacological effects, pharmacokinetics parameters and toxicity of ATR. The results indicated that ATR possesses a wide spectrum of chemical composition, including volatile oil, terpenoids, organic acids, flavonoids, amino acids, lignin, carbohydrates and so on. Accumulating evidence from various studies has shown that ATR exerts a wide range of pharmacological properties, including protecting nerve cells, alleviating learning an...
Source: Frontiers in Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research

ERLEADA ® (apalutamide), First-and-Only Next-Generation Androgen Receptor Inhibitor with Once-Daily, Single-Tablet Option, Now Available in the U.S.
HORSHAM, Pa., April 3, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the availability of an additional tablet strength of ERLEADA® (apalutamide) in the United States. The introduction of the 240mg tablet provides the first-and-only option for a once-daily, single-tablet Androgen Receptor Inhibitor (ARI) approved for the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC).With two strengths available, healthcare professionals will have the flexibility to...
Source: Johnson and Johnson - April 3, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Gastrodia elata Blume: A review of its mechanisms and functions on cardiovascular systems
Fitoterapia. 2023 Apr 17:105511. doi: 10.1016/j.fitote.2023.105511. Online ahead of print.ABSTRACTGastrodia elata Blume (GEB), commonly called Tianma in Chinese, is a valuable and extensively used herbal Traditional Chinese Medicine with a wide range of clinical applications. It has been used to treat headaches, dizziness, stroke, epilepsy, amnesia, spasm, and other disorders since ancient times. Hundreds of compounds, including Phenols, glycosides, polysaccharides, steroids, organic acids, and others, have been isolated and identified from this plant. Modern pharmacological studies have shown that its active ingredients p...
Source: Fitoterapia - April 17, 2023 Category: Biochemistry Authors: Xiaoning Sun Bo Jia Jingran Sun Jianguo Lin Bingjiu Lu Jinlong Duan Cheng Li Qingqing Wang Xin Zhang Meng Tan Dongsheng Zhong Xiaoxiao Zhang Ziyi Sun Yan Zhang Kuiwu Yao Source Type: research

Beware! We are Skating on a Thin Ice: Air Pollution is a Killer
J Assoc Physicians India. 2023 Jul;71(7):11-12.ABSTRACTAir pollution has rapidly emerged as a major environmental hazard in recent times, with potentially catastrophic ramifications for human health.1,2 It has the ability to severely and adversely impact multiple body systems, including the central nervous system (CNS), cardiovascular, dermatological, respiratory, ophthalmologic, and gastrointestinal health. It is a global public health hazard, being responsible for an estimated 6.7 million deaths worldwide in 2016. The World Health Organization (WHO) estimates that between 3.2 to 4.8 million persons succumb yearly because...
Source: Journal of the Association of Physicians of India - July 14, 2023 Category: General Medicine Authors: Man M Mehndiratta Divyani Garg Source Type: research

Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022
Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.
Source: Frontiers in Pharmacology - July 19, 2023 Category: Drugs & Pharmacology Source Type: research

Beware! We are Skating on a Thin Ice: Air Pollution is a Killer
J Assoc Physicians India. 2023 Jul;71(7):11-12.ABSTRACTAir pollution has rapidly emerged as a major environmental hazard in recent times, with potentially catastrophic ramifications for human health.1,2 It has the ability to severely and adversely impact multiple body systems, including the central nervous system (CNS), cardiovascular, dermatological, respiratory, ophthalmologic, and gastrointestinal health. It is a global public health hazard, being responsible for an estimated 6.7 million deaths worldwide in 2016. The World Health Organization (WHO) estimates that between 3.2 to 4.8 million persons succumb yearly because...
Source: Journal of the Association of Physicians of India - July 14, 2023 Category: General Medicine Authors: Man M Mehndiratta Divyani Garg Source Type: research

Selection of regioselective DNA aptamer for detection of homocysteine in nondeproteinized human plasma
Biosens Bioelectron. 2023 Jul 11;237:115528. doi: 10.1016/j.bios.2023.115528. Online ahead of print.ABSTRACTSmall molecule-binding aptamers often suffer from high cross reactivity to structure analogues in biological samples, limiting their value for clinical diagnosis. Herein, we present a method to overcome this issue, by performing binding-inhibited organic reaction-based regioselective selection of aptamers against homocysteine (Hcy), which is a marker for diagnosing many disorders including stroke and Alzheimer's. This approach has led to isolation of a DNA aptamer that binds to the alkane thiol chain of Hcy with exce...
Source: Biosensors and Bioelectronics - July 22, 2023 Category: Biotechnology Authors: Jianshuo Zhou Hui Li Jinming Li Xuemei Liu Jiaxing Zhao Nan Wang Yuxiao Wang Yu Zhang Xin Zhang Yucen Xin Xiaoqi Li Zheng Wang Ningsheng Shao Xinhui Lou Source Type: research

Beware! We are Skating on a Thin Ice: Air Pollution is a Killer
J Assoc Physicians India. 2023 Jul;71(7):11-12.ABSTRACTAir pollution has rapidly emerged as a major environmental hazard in recent times, with potentially catastrophic ramifications for human health.1,2 It has the ability to severely and adversely impact multiple body systems, including the central nervous system (CNS), cardiovascular, dermatological, respiratory, ophthalmologic, and gastrointestinal health. It is a global public health hazard, being responsible for an estimated 6.7 million deaths worldwide in 2016. The World Health Organization (WHO) estimates that between 3.2 to 4.8 million persons succumb yearly because...
Source: Journal of the Association of Physicians of India - July 14, 2023 Category: General Medicine Authors: Man M Mehndiratta Divyani Garg Source Type: research

Selection of regioselective DNA aptamer for detection of homocysteine in nondeproteinized human plasma
Biosens Bioelectron. 2023 Jul 11;237:115528. doi: 10.1016/j.bios.2023.115528. Online ahead of print.ABSTRACTSmall molecule-binding aptamers often suffer from high cross reactivity to structure analogues in biological samples, limiting their value for clinical diagnosis. Herein, we present a method to overcome this issue, by performing binding-inhibited organic reaction-based regioselective selection of aptamers against homocysteine (Hcy), which is a marker for diagnosing many disorders including stroke and Alzheimer's. This approach has led to isolation of a DNA aptamer that binds to the alkane thiol chain of Hcy with exce...
Source: Biosensors and Bioelectronics - July 22, 2023 Category: Biotechnology Authors: Jianshuo Zhou Hui Li Jinming Li Xuemei Liu Jiaxing Zhao Nan Wang Yuxiao Wang Yu Zhang Xin Zhang Yucen Xin Xiaoqi Li Zheng Wang Ningsheng Shao Xinhui Lou Source Type: research

Beware! We are Skating on a Thin Ice: Air Pollution is a Killer
J Assoc Physicians India. 2023 Jul;71(7):11-12.ABSTRACTAir pollution has rapidly emerged as a major environmental hazard in recent times, with potentially catastrophic ramifications for human health.1,2 It has the ability to severely and adversely impact multiple body systems, including the central nervous system (CNS), cardiovascular, dermatological, respiratory, ophthalmologic, and gastrointestinal health. It is a global public health hazard, being responsible for an estimated 6.7 million deaths worldwide in 2016. The World Health Organization (WHO) estimates that between 3.2 to 4.8 million persons succumb yearly because...
Source: Journal of the Association of Physicians of India - July 14, 2023 Category: General Medicine Authors: Man M Mehndiratta Divyani Garg Source Type: research