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Total 304 results found since Jan 2013.

Pulmonary Vasodilation by Intravenous Infusion of Organic Mononitrites Of 1,2-Propanediol in Acute Pulmonary Hypertension Induced by Aortic Cross Clamping and Reperfusion: A Comparison With Nitroglycerin in Anesthetized Pigs
Conclusions: PDNO was an effective pulmonary vasodilator and appeared superior to nitroglycerin and inorganic nitrite, without causing significant systemic hypotension, impaired arterial oxygenation, or methaemoglobin formation in an animal model of SRACC and reperfusion. Also, PDNO may have kidney-protective effects and anti-inflammatory properties.
Source: Shock - June 12, 2020 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Two Cu(II)-organic frameworks: effective CO2 fixation and protective activity on the motor function after stroke by increasing neural stem cells differentiation
Publication date: Available online 11 July 2020Source: Inorganica Chimica ActaAuthor(s): Qing Ye, Li Zhang, Zhou-Li Shao, Wei Zhang, Chao Li, Xiang-Ming Ye
Source: Inorganica Chimica Acta - July 11, 2020 Category: Chemistry Source Type: research

A Review of the Botany, Traditional Use, Phytochemistry, Analytical Methods, Pharmacological Effects, and Toxicity of Angelicae Pubescentis Radix.
Authors: Yang L, Hou A, Wang S, Zhang J, Man W, Guo X, Yang B, Jiang H, Kuang H, Wang Q Abstract Angelicae Pubescentis Radix (AP), as a traditional Chinese medicine (TCM), has been used for thousands of years in China. In this paper, the botany, traditional use, phytochemistry, analytical methods, quality control, pharmacological effects, and toxicity of AP were reviewed. It can provide a reference for the further research and lay a foundation for the rational clinical application of AP. The relevant information on AP was collected from scientific databases (such as Baidu Scholar, CNKI, Google Scholar, PubMed, Scie...
Source: Evidence-based Complementary and Alternative Medicine - August 25, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Physiologically ‐based Pharmacokinetic Modeling for the Prediction of a Drug‐Drug Interaction of Combined Effects on P‐gp and CYP3A
AbstractDirect oral anticoagulants, like apixaban and rivaroxaban, are important for the treatment and prophylaxis of venous thromboembolism and to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Since apixaban and rivaroxaban are predominantly eliminated by CYP3A and P ‐glycoprotein (P‐gp), concomitant use of combined P‐gp and strong CYP3A4 inhibitors and inducers should be avoided. Physiologically‐based pharmacokinetic (PBPK) models for apixaban and rivaroxaban were developed to estimate the net effect of CYP3A induction, P‐gp inhibition and P‐gp indu ction by...
Source: CPT: Pharmacometrics and Systems Pharmacology - October 8, 2020 Category: Drugs & Pharmacology Authors: Yukio Otsuka, Mary P. Choules, Peter L. Bonate, Kanji Komatsu Tags: ARTICLE Source Type: research

Physiologically ‐Based Pharmacokinetic Modeling for the Prediction of a Drug–Drug Interaction of Combined Effects on P‐glycoprotein and Cytochrome P450 3A
Direct oral anticoagulants, such as apixaban and rivaroxaban, are important for the treatment and prophylaxis of venous thromboembolism and to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Because apixaban and rivaroxaban are predominantly eliminated by cytochrome P450 (CYP) 3A and P ‐glycoprotein (P‐gp), concomitant use of combined P‐gp and strong CYP3A4 inhibitors and inducers should be avoided. Physiologically‐based pharmacokinetic models for apixaban and rivaroxaban were developed to estimate the net effect of CYP3A induction, P‐gp inhibition, and P‐gp ind...
Source: CPT: Pharmacometrics and Systems Pharmacology - November 12, 2020 Category: Drugs & Pharmacology Authors: Yukio Otsuka, Mary P. Choules, Peter L. Bonate, Kanji Komatsu Tags: Article Source Type: research

Molecules, Vol. 26, Pages 1202: Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer ’s Disease and Parkinson’s Disease Treatment (2011–2020)
Molecules, Vol. 26, Pages 1202: Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020) Molecules doi: 10.3390/molecules26051202 Authors: Xuefei Li Yanbo Yu Zhude Tu The remarkable prevalence of pyrazole scaffolds in a versatile array of bioactive molecules ranging from apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to bixafen, a pyrazole-carboxamide fungicide used to control diseases of rapeseed and cereal plants, has encouraged both medicinal and organic chemists to explore new methods in developi...
Source: Molecules - February 24, 2021 Category: Chemistry Authors: Xuefei Li Yanbo Yu Zhude Tu Tags: Review Source Type: research

1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis
In conclusion, our results demonstrate that 1,2,4-TTB is an NLRP3 inflammasome inhibitor and attenuates the clinical symptom and inflammation of EAE, suggesting that 1,2,4-TTB is a potential candidate compound for treating NLRP3 inflammasome-driven diseases, such as multiple sclerosis.PMID:33627802 | DOI:10.1038/s41401-021-00613-8
Source: Acta Pharmacologica Sinica - February 25, 2021 Category: Drugs & Pharmacology Authors: Rui-Yuan Pan Xiang-Xi Kong Yong Cheng Lu Du Zhen-Chao Wang Chao Yuan Jin-Bo Cheng Zeng-Qiang Yuan Hai-Yan Zhang Ya-Jin Liao Source Type: research

Fish, Cardiovascular Disease, and Mortality
Fish and shellfish (hereafter referred to as fish) are major sources of the dietary long-chain ω-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) and also contain other nutrients, such as vitamin D, riboflavin, iodine, calcium, phosphorus, magnesium, potassium, zinc, and iron. The summed results of observational studies of fish intake, randomized clinical tria ls of fish oil supplements, and associated mechanistic and experimental studies suggest that regular fish consumption may decrease the incidence of myocardial infarction (MI) and coronary heart disease (CHD), with more uncertain effec...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research

Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents
Drug Metab Pharmacokinet. 2021 Mar 20;38:100390. doi: 10.1016/j.dmpk.2021.100390. Online ahead of print.ABSTRACTThe combination of antiarrhythmic agents, amiodarone or dronedarone, with the anticoagulant rivaroxaban is used clinically in the management of atrial fibrillation for rhythm control and secondary stroke prevention respectively. Renal drug-drug interactions (DDIs) between amiodarone or dronedarone and rivaroxaban were previously ascribed to inhibition of rivaroxaban secretion by P-glycoprotein at the apical membrane of renal proximal tubular epithelial cells. Benzbromarone, a known inhibitor of organic anion tran...
Source: Drug Metabolism and Pharmacokinetics - April 9, 2021 Category: Drugs & Pharmacology Authors: Heng Lin Tan Lloyd Wei Tat Tang Sheng Yuan Chin Eric Chun Yong Chan Source Type: research