1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis

In conclusion, our results demonstrate that 1,2,4-TTB is an NLRP3 inflammasome inhibitor and attenuates the clinical symptom and inflammation of EAE, suggesting that 1,2,4-TTB is a potential candidate compound for treating NLRP3 inflammasome-driven diseases, such as multiple sclerosis.PMID:33627802 | DOI:10.1038/s41401-021-00613-8

Source: Acta Pharmacologica Sinica - February 25, 2021 Category: Drugs & Pharmacology Authors: Rui-Yuan Pan Xiang-Xi Kong Yong Cheng Lu Du Zhen-Chao Wang Chao Yuan Jin-Bo Cheng Zeng-Qiang Yuan Hai-Yan Zhang Ya-Jin Liao Source Type: research