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Total 338 results found since Jan 2013.
Acute Vascular Ischemic Events in Patients with Central Retinal Artery Occlusion in the United States: A Nationwide Study 2003-2014
Central retinal artery occlusion (CRAO) confers a high risk of acute vascular ischemic events, including stroke and myocardial infarction (MI). Understanding the burden and risk factor profile of these ischemic events can serve as a valuable guide for ophthalmologists in the management and appropriate referral of these patients.
Source: American Journal of Ophthalmology - January 26, 2019 Category: Opthalmology Authors: Tahreem A. Mir, Ahmad Z. Arham, Wei Fang, Fahad Alqahtani, Mohamad Alkhouli, Julia Gallo, David M. Hinkle Tags: Original Articles Source Type: research
Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model.
CONCLUSIONS: Our studies provide a novel mechanism whereby loss of Smad4 causes increased Angpt2 transcription in ECs leading to AVM formation, increased blood vessel calibers and changes in EC morphology in the retina. Blockade of ANGPT2 function in an in vivo Smad4 model of HHT alleviated these vascular phenotypes further implicating ANGPT2 as an important TGFβ downstream mediator of AVM formation. Therefore, alternative approaches that target ANGPT2 function may have therapeutic value for the alleviation of HHT symptoms, such as AVMs.
PMID: 30744395 [PubMed - as supplied by publisher]
Source: Circulation - February 12, 2019 Category: Cardiology Authors: Crist AM, Zhou X, Garai J, Lee AR, Thoele J, Ullmer C, Klein C, Zabaleta J, Meadows SM Tags: Circulation Source Type: research
Inappropriate non-vitamin K antagonist oral anticoagulants prescriptions: be cautious with dose reductions.
CONCLUSION: An incorrect prescription occurred more often in the reduced-dose NOAC group. Clinical parameters such as renal function are often unknown whilst these are essential to determine the right NOAC and dose.
PMID: 30949972 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - April 3, 2019 Category: Cardiology Authors: Jacobs MS, van Hulst M, Campmans Z, Tieleman RG Tags: Neth Heart J Source Type: research
Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease
Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5*
1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore
2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore
3Department of Neurology, National Neuroscience Institute, Singapore, Singapore
4Duke-National University of Singapore (NUS), Singapore, Singapore
5Singapore National Eye Centre, Singapore, Singapore
The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research
Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion
The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research
A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation.
Background
Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research
Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis.
Introduction
Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Genetic polymorphisms associated with the prevalence of retinal vein occlusion in a Greek population
ConclusionsAGTR1 A1166C andGpla/lla C807T/G873A polymorphisms are likely to be risk factors for CRVO.Adiponectin + 276 G/T SNP is likely to predispose to RVO in older subjects.
Source: International Ophthalmology - May 6, 2019 Category: Opthalmology Source Type: research
Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality.
CONCLUSIONS: In this long-term prospective cohort study, higher baseline serum α-tocopherol biochemical status was associated with lower risk of overall mortality and mortality from all major causes. Our data support the long-term health benefits of higher serum α-tocopherol for overall and chronic disease mortality and should be replicated in other more diverse populations.
PMID: 31219752 [PubMed - in process]
Source: Circulation Research - June 20, 2019 Category: Cardiology Authors: Huang J, Weinstein SJ, Yu K, Männistö S, Albanes D Tags: Circ Res Source Type: research
PERSPECTIVES Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies
The α7 nicotinic acetylcholine receptor (α7nAChR) is central to the anti-inflammatory function of the vagus nerve in a physiological mechanism termed the inflammatory reflex. Studies on the inflammatory reflex have been instrumental for the current development of the field of bioelectronic medicine. An independent investigation of the biological role of αB-crystallin (HspB5), the most abundant gene transcript present in active multiple sclerosis lesions in human brains, also led to α7nAChR. Induction of experimental autoimmune encephalomyelitis (EAE) in HspB5–/– mice results in greater p...
Source: Cold Spring Harbor perspectives in medicine - June 30, 2019 Category: Research Authors: Rothbard, J. B., Kurnellas, M. P., Ousman, S. S., Brownell, S., Rothbard, J. J., Steinman, L. Tags: Bioelectronic Medicine PERSPECTIVES Source Type: research
Neurological complications associated with dengue virus infection.
CONCLUSIONS: The spectrum of neurological complications from dengue virus is broad. There are no reliable data on its real incidence because most of the studies published to date are isolated series or cases.
PMID: 31310001 [PubMed - in process]
Source: Revista de Neurologia - July 18, 2019 Category: Neurology Authors: Carod-Artal FJ Tags: Rev Neurol Source Type: research
Association of plasma retinol levels with incident cancer risk in Chinese hypertensive adults: a nested case-control study.
In conclusion, there was a significant inverse dose-response association between plasma retinol and the risk of digestive system cancers. However, a U-shaped association was observed between plasma retinol and the risk of non-digestive cancers (with a turning point approximately 68·2 μg/dl).
PMID: 31352906 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - July 28, 2019 Category: Nutrition Authors: Xie L, Song Y, Lin T, Guo H, Wang B, Tang G, Liu C, Huang W, Yang Y, Ling W, Zhang Y, Li J, Huo Y, Wang X, Zhang H, Qin X, Xu X Tags: Br J Nutr Source Type: research
Preventive Effects of Dexmedetomidine on Renal Dysfunction and Hemodynamic Stability in Malignant Obstructive Jaundice Patients During Peri-Operative Period.
CONCLUSIONS Dexmedetomidine plays preventive effects on renal dysfunction and hemodynamic stability in malignant obstructive jaundice patients during peri-operative period.
PMID: 31498783 [PubMed - in process]
Source: Medical Science Monitor - September 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research
Phenotypic Delineation of the Retinal Arterial Macroaneurysm with Supravalvular Pulmonic Stenosis (RAMSVPS) Syndrome.
This article is protected by copyright. All rights reserved.
PMID: 31730227 [PubMed - as supplied by publisher]
Source: Clinical Genetics - November 14, 2019 Category: Genetics & Stem Cells Authors: Alkuraya H, Patel N, Ibrahim N, Al Ghamdi B, Alsulaiman SM, Nowilaty SR, Abboud E, Alturki R, Alkharashi A, Eyaid W, Almasseri Z, Alzaidan H, Alotaibi MD, Abu El-Asrar AM, Alamro B, Helaby R, Elshaer A, Almontashiri NAM, Al-Hussaini AA, Alkuraya FS Tags: Clin Genet Source Type: research
Vitrectomy for idiopathic macular hole in patients aged 80 years or older: efficacy and safety.
Conclusions: The results from our study indicate the efficacy and safety of vitrectomy for idiopathic macular hole in patients aged 80 years or older, and idiopathic MH surgery should not be denied on basis of patient age alone.
PMID: 31747306 [PubMed - as supplied by publisher]
Source: Current Eye Research - November 19, 2019 Category: Opthalmology Authors: Wang J, Li Q, Jiang J, Che X, Qian Y, Zhou X, Zhang Y, Wang Z Tags: Curr Eye Res Source Type: research
