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Total 1731 results found since Jan 2013.
Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
Aphasia is a language disorder that occurs after a stroke and impairs listening, speaking, reading, writing, and calculation skills. Patients with post-stroke aphasia in Japan are increasing due to population aging and the advancement of medical treatment. Opportunities for adequate speech therapy in chronic stroke are limited due to time constraints. Recent studies have reported that intensive speech therapy for a short period of time or continuous speech therapy using high-tech equipment, including speech applications (apps, can improve aphasia even in the chronic stage. However, its underlying mechanism for improving la...
Source: Frontiers in Human Neuroscience - September 22, 2022 Category: Neuroscience Source Type: research
Cost-effectiveness Analysis of Apixaban against Warfarin for Stroke Prevention in Patients with Nonvalvular Atrial Fibrillation in Japan.
CONCLUSION: Although most participants in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial used for the efficacy data of apixaban in the model were non-Japanese patients, the impact of the limitations on our results was considered small, and our results were deemed robust because of the additional effect in Japanese patients compared with that in the global population according to the subanalysis of Japanese patients in the trial. Therefore, based on an adaptation of a published Markov model, apixaban is a cost-effective alternative to warfarin in Japan for strok...
Source: Clinical Therapeutics - November 19, 2015 Category: Drugs & Pharmacology Authors: Kamae I, Hashimoto Y, Koretsune Y, Tanahashi N, Murata T, Phatak H, Liu LZ, Tang AC, Feng Wang P, Okumura K Tags: Clin Ther Source Type: research
Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness Clinical Sciences
Conclusions—The usual Japanese dose of pravastatin significantly reduced the progression of carotid IMT at 5 years in patients with noncardioembolic stroke.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00361530.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Masatoshi Koga, Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Tatsuo Kagimura, Hideki Origasa, Kenji Kamiyama, Rieko Suzuki, Toshiho Ohtsuki, Hirofumi Maruyama, Kazuo Kitagawa, Shinichiro Uchiyam Tags: Risk Factors, Secondary Prevention, Ultrasound, Atherosclerosis Original Contributions Source Type: research
A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial - PRASTRO-I trial.
CONCLUSIONS: This article presents the study design and rationale for a trial investigating the noninferiority of prasugrel to clopidogrel sulfate with regards to the inhibitory effect on primary events in patients with non-cardioembolic stroke.
PMID: 29463150 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - February 25, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Study of Pharmacodynamic and Pharmacokinetic Interaction of Bojungikki-Tang with Aspirin in Healthy Subjects and Ischemic Stroke Patients.
Conclusions: These results suggest that coadministration of BJIKT with aspirin may not result in herb-drug interaction.
PMID: 29599812 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - March 31, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Haptic-based perception-empathy biofeedback system for balance rehabilitation in patients with chronic stroke: Concepts and initial feasibility study
Stroke is the leading cause of long-term disability, annually experienced by approximately 250,000 individuals in Japan and remains a major healthcare and economic issue [1]. In stroke patients, a complex interplay of sensory, motor, and cognitive impairments causes balance issues [2]. Therefore, most stroke patients show increased postural sway during quiet standing and asymmetric weight distribution [2 –4]. Regarding post-stroke balance disability, impaired balance reportedly predicts falls in elderly patients post stroke [5].
Source: Gait and Posture - April 14, 2018 Category: Orthopaedics Authors: Kazuhiro Yasuda, Kenta Saichi, Naomi Kaibuki, Hiroaki Harashima, Hiroyasu Iwata Tags: Full length article Source Type: research
Anticoagulants, Reperfusion Therapy, and Outcomes in Ischemic Stroke Patients With Non-Valvular Atrial Fibrillation - A Single-Center, 6-Year Experience of 546 Consecutive Patients.
CONCLUSIONS: Inappropriate anticoagulant use for stroke patients with NVAF did not decrease over time. An increase in reperfusion therapy was a strong factor in improved functional outcomes and mortality.
PMID: 30158346 [PubMed - as supplied by publisher]
Source: Circulation Journal - August 30, 2018 Category: Cardiology Authors: Suda S, Sakamoto Y, Okubo S, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Kutsuna A, Matsumoto N, Nito C, Nishiyama Y, Mishina M, Kimura K Tags: Circ J Source Type: research
Prediction of life-space mobility in patients with stroke 2 months after discharge from rehabilitation: a retrospective cohort study.
CONCLUSIONS: The predictive formula provides an objective measure of life-space mobility for stroke patients after discharge. The clinical application of this formula could help health care professionals working in stroke rehabilitation to prepare patients for discharge and to set concrete goals for in-hospital rehabilitation to improve life-space mobility after discharge. Implications for rehabilitation Accurate prediction of the prognosis for life-space mobility 2 months after discharge is useful in establishing clear goals for community-based rehabilitation. Long-term life-space mobility in the community is not only aff...
Source: Disability and Rehabilitation - January 24, 2019 Category: Rehabilitation Authors: Nakao M, Izumi S, Yokoshima Y, Matsuba Y, Maeno Y Tags: Disabil Rehabil Source Type: research
Association of CYP2C19 Polymorphisms With Clopidogrel Reactivity and Clinical Outcomes in Chronic Ischemic Stroke.
CONCLUSIONS: Despite associations betweenCYP2C19variants and on-clopidogrel platelet reactivity, there was no significant difference in rates of CVEs in the chronic stroke phase among the 3 clopidogrel-metabolizing groups ofCYP2C19variants.
PMID: 31006731 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 18, 2019 Category: Cardiology Authors: Tanaka T, Yamagami H, Ihara M, Miyata T, Miyata S, Hamasaki T, Amano S, Fukuma K, Yamamoto H, Nakagawara J, Furui E, Uchiyama S, Hyun B, Yamamoto Y, Manabe Y, Ito Y, Fukunaga R, Abumiya T, Yasaka M, Kitagawa K, Toyoda K, Nagatsuka K Tags: Circ J Source Type: research
Clinical risk factors of stroke and major bleeding in patients with non-valvular atrial fibrillation under rivaroxaban: the EXPAND Study sub-analysis
AbstractFor Japanese patients with non-valvular atrial fibrillation (NVAF), the risk of stroke and major bleeding events was assessed by using the CHADS2, CHA2DS2-VASc, and HAS-BLED scores. The risk factors for embolism and major bleeding under DOAC may be different from current reports. We analyzed the data set of the EXPAND Study to determine the risk factors for events among Japanese NVAF patients in the era of direct oral anticoagulant. Using the data of EXPAND Study, the validity for predictability of the CHADS2, CHA2DS2-VASc, and HAS-BLED scores was identified using the receiver operating characteristic curve analysi...
Source: Heart and Vessels - October 15, 2019 Category: Cardiology Source Type: research
Prevalence and Associated Stroke Risk of Human Immunodeficiency Virus-Infected Patients With Atrial Fibrillation - A Nationwide Cohort Study.
CONCLUSIONS: The risks of ischemic stroke/SE and major bleeding were significantly higher in HIV-infected patients compared with non-HIV-infected patients with AF. Despite this, the actual use of OACs among AF patients with HIV was suboptimal.
PMID: 31619594 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 16, 2019 Category: Cardiology Authors: Jung H, Yang PS, Jang E, Yu HT, Kim TH, Uhm JS, Kim JY, Sung JH, Pak HN, Lee MH, Lip GYH, Joung B Tags: Circ J Source Type: research
Urinary Stones and Risk of Coronary Heart Disease and Stroke: the Japan Public Health Center-Based Prospective Study.
CONCLUSION: The history of urinary stones was shown to be not associated with the risk of CVD among Japanese adults.
PMID: 32507830 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - June 10, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
IJERPH, Vol. 18, Pages 1632: The Effect of Minimum and Maximum Air Temperatures in the Summer on Heat Stroke in Japan: A Time-Stratified Case-Crossover Study
We examined the impact of summer minimum air temperatures, which often represent nighttime temperatures, as well as a maximum temperature on a heat stroke. We collected data from the records of daily ambulance transports for heat strokes and meteorological data for July and August of 2017–2019 in the Tottori Prefecture, Japan. A time-stratified case-crossover design was used to determine the association of maximum/minimum air temperatures and the incidence of heat strokes. We used a logistic regression to identify factors associated with the severity of heat strokes. A total of 1108 cases were identified with 373 (33.7%)...
Source: International Journal of Environmental Research and Public Health - February 9, 2021 Category: Environmental Health Authors: Shinji Otani Satomi Funaki Ishizu Toshio Masumoto Hiroki Amano Youichi Kurozawa Tags: Article Source Type: research
Reliability and validity of Japanese version of Fugl-Meyer assessment for the lower extremities
Conclusions: The Japanese FMA-LE was reliable, valid, and useful for evaluating lower extremity function of acute stroke patients.PMID:33724162 | DOI:10.1080/10749357.2021.1899700
Source: Topics in Stroke Rehabilitation - March 16, 2021 Category: Neurology Authors: Tetsuharu Nakazono Kayoko Takahashi Yoshikazu Suzuki Kosuke Mizuno Yuko Nomura Yoshimi Hiraga Shuji Matsumoto Kazutoshi Nishiyama Michinari Fukuda Source Type: research
A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation
CONCLUSIONS: The HELT-E2S2score may be useful for identifying Japanese NVAF patients at risk of ischemic stroke.PMID:33762526 | DOI:10.1253/circj.CJ-20-1075
Source: Circulation Journal - March 25, 2021 Category: Cardiology Authors: Ken Okumura Hirofumi Tomita Michikazu Nakai Eitaro Kodani Masaharu Akao Shinya Suzuki Kenshi Hayashi Mitsuaki Sawano Masahiko Goya Takeshi Yamashita Keiichi Fukuda Hisashi Ogawa Toyonobu Tsuda Mitsuaki Isobe Kazunori Toyoda Yoshihiro Miyamoto Hiroaki Miya Source Type: research
