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Total 1731 results found since Jan 2013.

Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring α-Galactosidase A and Globotriaosylsphingosine
Fabry disease is an X-linked lysosomal storage disorder caused by mutations in GLA, which encodes the enzyme α-galactosidase A (α-Gal A). Although the prevalence of Fabry disease in patients with stroke has been reported to range from 0% to 4%, few cohort studies have examined Japanese stroke patients. We aimed to clarify the prevalence of Fabry disease and the frequency of GLA mutations among patients w ith young-onset stroke in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2018 Category: Neurology Authors: Naoto Kinoshita, Naohisa Hosomi, Hayato Matsushima, Masahiro Nakamori, Yoshiki Yagita, Takemori Yamawaki, Tsuyoshi Torii, Takeshi Kitamura, Yoshimasa Sueda, Ryo Shimomura, Mutsuko Araki, Tomohisa Nezu, Shiro Aoki, Satoshi Ishii, Hiroki Maruyama, Masayasu Source Type: research

Cost Effectiveness of Drive and Retrieve System in Hokkaido for Acute Ischemic Stroke Patient Treatment Using Geographic Information System
This study aims to simulate the cost effectiveness of the drive and retrieve system, which can be a method to enhance equality and cost effectiveness of treatments for acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 11, 2019 Category: Neurology Authors: Yasuhiro Morii, Toshiya Osanai, Tomoki Ishikawa, Kensuke Fujiwara, Takumi Tanikawa, Kiyohiro Houkin, Eiichi Kobayashi, Katsuhiko Ogasawara Source Type: research

Dabigatran for Japanese Patients with Atrial Fibrillation and Prior Stroke: A Subgroup Analysis of the J-Dabigatran Surveillance Program
Background: The study objective was to evaluate long-term safety and effectiveness of dabigatran 110 mg and 150 mg twice daily (bid) in patients with nonvalvular atrial fibrillation (NVAF) with a focus on secondary stroke prevention. Methods: In J-Dabigatran Surveillance, 6772 patients newly initiated on dabigatran to prevent ischemic stroke and systemic embolism were enrolled in Japan (1042 sites, December 2011 to November 2013). This subgroup analysis included patients with (1302) and without (5071) previous stroke/transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - February 25, 2020 Category: Neurology Authors: Masahiro Yasaka, Shinichiro Uchiyama, Hirotsugu Atarashi, Ken Okumura, Yukihiro Koretsune, Takeshi Yamashita, Atsushi Taniguchi, Taku Fukaya, Hiroshi Inoue, for the J-Dabigatran Surveillance Investigators Tags: Original article Source Type: research

Development of Machine Learning Models to Predict Probabilities and Types of Stroke at Prehospital Stage: the Japan Urgent Stroke Triage Score Using Machine Learning (JUST-ML)
AbstractIn conjunction with recent advancements in machine learning (ML), such technologies have been applied in various fields owing to their high predictive performance. We tried to develop prehospital stroke scale with ML. We conducted multi-center retrospective and prospective cohort study. The training cohort had eight centers in Japan from June 2015 to March 2018, and the test cohort had 13 centers from April 2019 to March 2020. We use the three different ML algorithms (logistic regression, random forests, XGBoost) to develop models. Main outcomes were large vessel occlusion (LVO), intracranial hemorrhage (ICH), suba...
Source: Translational Stroke Research - August 14, 2021 Category: Neurology Source Type: research

Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke
An association between serum uric acid and outcomes of ischemic stroke has been reported, but the results are controversial. The aim of this study is to clarify how uric acid may affect activities of daily living after acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 6, 2017 Category: Neurology Authors: Shinya Kawase, Hisanori Kowa, Yutaka Suto, Hiroki Fukuda, Masayoshi Kusumi, Hiroyuki Nakayasu, Kenji Nakashima Source Type: research

Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats
Conclusion: The current study shows for the first time that in hypertension the number of TF-positive megakaryocytes increases thus releasing in the circulation more platelets carrying a functionally active TF. AngII stimulates platelets to express TF.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Effectiveness of Intensive Rehabilitation Therapy on Functional Outcomes After Stroke: A Propensity Score Analysis Based on Japan Rehabilitation Database
This study was a retrospective cohort study. From the database, 6875 patients who were admitted to the convalescent rehabilitation wards with stroke were identified. After excluding 4586 patients, 2325 were eligible for the study. Intensive rehabilitation therapy (IRT) was defined as rehabilitation therapy of more than 15 hours per week by a physical therapist, an occupational therapist, and/or a speech therapist.
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2019 Category: Neurology Authors: Tomohiko Kamo, Ryo Momosaki, Keisuke Suzuki, Ryoma Asahi, Masato Azami, Hirofumi Ogihara, Yuusuke Nishida Source Type: research

Prevalence and Predictors of Multivitamin Supplement Use After Stroke in Ghana
Multivitamin supplementation is widely practiced in high-income countries due to a popular belief of its health promotion and disease prevention benefits. Evidence for their purported efficacy has been mixed. Regarding the efficacy of multivitamins on prevention of cardiovascular disease, cancer, or all-cause mortality, some studies have shown no effect,1 –4 harmful effects,5,6 and beneficial effects.7,8 Three prospective studies have evaluated the effect of multivitamin use on stroke prevention with two showing negative outcomes3,5 and the third among 72,000 Japanese showing frequent use of multivitamins was associated ...
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2021 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Source Type: research

Accelerating Cell Therapy for Stroke in Japan Special Reports
Source: Stroke - March 26, 2018 Category: Neurology Authors: Kiyohiro Houkin, Hideo Shichinohe, Koji Abe, Teruyo Arato, Mari Dezawa, Osamu Honmou, Nobutaka Horie, Yasuo Katayama, Kohsuke Kudo, Satoshi Kuroda, Tomohiro Matsuyama, Ichiro Miyai, Izumi Nagata, Kuniyasu Niizuma, Ken Sakushima, Masanori Sasaki, Norihiro Tags: Cell Therapy, Clinical Studies, Stem Cells, Translational Studies, Ischemic Stroke Special Report Source Type: research

A Case of Posterior Circulation Ischemic Stroke Caused by Heparin-Induced Thrombocytopenia after Detaining Hepatic Arterial Infusion Catheter
In Japan, hepatic arterial infusion chemotherapy (HAIC) using reservoir system is recommended for patients with hepatocellular carcinoma (HCC) whose hepatic spare ability is favorable. Arterial infusion catheter is commonly detained in hepatic artery via femoral or brachial artery. In our hospital, catheter is often inserted by puncturing the left subclavian or brachial artery considering the patient's activities of daily living (ADL) during long-term detaining. However, it rarely causes posterior circulation ischemic stroke because of the left vertebral artery branches on the path of catheter.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2018 Category: Neurology Authors: Koji Hirashita, Atsushi Matsumoto, Satoru Yabuno, Takahiro Kanda, Masatoshi Yunoki, Kimihiro Yoshino Tags: Case Studies Source Type: research

Thrombectomy for Stroke at 6-24 hours without Perfusion CT Software for Patient Selection
This study aimed to elucidate the efficacy of thrombectomy 6-24 hours after onset in our patient cohort using conventional imaging mismatch.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2018 Category: Neurology Authors: Junya Tsurukiri, Takahiro Ota, Hiroyuki Jimbo, Eitaro Okumura, Keigo Shigeta, Tatsuo Amano, Masayuki Ueda, Yuji Matsumaru, Yoshiaki Shiokawa, Teruyuki Hirano Source Type: research

Secondary stroke prevention with apixaban in nonvalvular atrial fibrillation: A subgroup analysis of the STANDARD study
Data on independent risk factors for stroke recurrence in Japanese patients with nonvalvular atrial fibrillation are limited.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Masahiro Yasaka, Michiaki Umeyama, Hirohide Kataoka, Hiroshi Inoue Source Type: research

Endovascular Therapy for Acute Ischemic Stroke in Patients with Large-Vessel Occlusion due to Atherosclerotic Stenosis
This study aimed to evaluate the differences in clinical results between the two subtypes using data from a multicenter prospective registry (RESCUE-Japan Registry 2).
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2021 Category: Neurology Authors: Manabu Shirakawa, Hidetoshi Matsukawa, Nobuyuki Sakai, Hiroshi Yamagami, Kanta Tanaka, Hirotoshi Imamura, Yasushi Matsumoto, Masataka Takeuchi, Hiroto Kageyama, Kazutaka Uchida, Takeshi Morimoto, Shinichi Yoshimura Source Type: research

Pediatric arterial ischemic stroke in Japan: Moyamoya disease or not
In this study, among 93 responders from physicians in 50 pediatric hospitals, consensus agreement, being available to treat pediatric AIS, was 90.3% in the use of intravenous tissue plasminogen activator (tPA) and 77.4% in mechanical thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2023 Category: Neurology Authors: Shunji Mugikura, Naoko Mori Tags: Letter to the Editor Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research