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Total 1014 results found since Jan 2013.
An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics Biophysics and Computational Biology
Myosins form a class of actin-based, ATPase motor proteins that mediate important cellular functions such as cargo transport and cell motility. Their functional cycle involves two large-scale swings of the lever arm: the force-generating powerstroke, which takes place on actin, and the recovery stroke during which the lever arm is...
Source: Proceedings of the National Academy of Sciences - June 12, 2018 Category: Science Authors: Florian Blanc, Tatiana Isabet, Hannah Benisty, H. Lee Sweeney, Marco Cecchini, Anne Houdusse Tags: Biological Sciences Source Type: research
Excess body fat improves stroke survival rates
Findings, presented at the American Academy of Neurology's 71st Annual Meeting, suggest that being overweight or obese may improve survival chances after a stroke, an obesity paradox.Medical News Today
Source: Society for Endocrinology - March 13, 2019 Category: Endocrinology Source Type: news
Direct Oral Anticoagulants vs. Warfarin to Prevent Stroke and Embolic Events in Patients with Atrial Fibrillation and CKD.
PMID: 30932459 [PubMed - in process]
Source: American Family Physician - March 31, 2019 Category: Primary Care Authors: Lax JW, Wood R, Jonas CE Tags: Am Fam Physician Source Type: research
A Rare but Disabling Stroke.
PMID: 30997481 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - February 28, 2019 Category: General Medicine Authors: Lau KF, Tan KS, Goh KJ, Ramli N, Tai SM Tags: Ann Acad Med Singapore Source Type: research
Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke Neuroscience
In this study, we investigated the role of tPA on primary neurons in culture and on brain recovery and plasticity after ischemic...
Source: Proceedings of the National Academy of Sciences - April 29, 2019 Category: Science Authors: Hongjian Pu, Yejie Shi, Lili Zhang, Zhengyu Lu, Qing Ye, Rehana K. Leak, Fei Xu, Shubei Ma, Hongfeng Mu, Zhishuo Wei, Na Xu, Yuguo Xia, Xiaoming Hu, T. Kevin Hitchens, Michael V. L. Bennett, Jun Chen Tags: PNAS Plus Source Type: research
Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke Neuroscience
Stroke is a major cause of serious disability due to the brain’s limited capacity to regenerate damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and inflammatory response is coupled with severely restricted vascular and neuronal repair, resulting in permanent functional deficits. Although clinical evidence indicates that revascularization...
Source: Proceedings of the National Academy of Sciences - July 8, 2019 Category: Science Authors: Ruslan Rust, Lisa Gronnert, Christina Gantner, Alinda Enzler, Geertȷe Mulders, Rebecca Z. Weber, Arthur Siewert, Yanuar D. P. Limasale, Andrea Meinhardt, Michael A. Maurer, Andrea M. Sartori, Anna–Sophie Hofer, Carsten Werner, Martin E. Schwa Tags: PNAS Plus Source Type: research
Dapagliflozin in High-Risk Type 2 Diabetes Reduces Hospitalization for Heart Failure But Does Not Reduce Death, Myocardial Infarction, or Stroke.
PMID: 31361104 [PubMed - in process]
Source: American Family Physician - July 31, 2019 Category: Primary Care Authors: Ebell MH Tags: Am Fam Physician Source Type: research
Short-Term Clopidogrel Plus Aspirin Prevents Second Ischemic Stroke Better Than Aspirin Alone.
PMID: 31414775 [PubMed - in process]
Source: American Family Physician - August 14, 2019 Category: Primary Care Authors: Shaughnessy AF Tags: Am Fam Physician Source Type: research
Mitral Valve Prolapse More Prevalent in Patients With Panic Disorder, Study Finds
Mitral valve prolapse (MVP), which occurs when the valve between the left upper and lower chambers of the heart does not close properly, is significantly more common in patients with panic disorder/agoraphobia, according to ameta-analysis inPsychosomatics (The Journal of Consultation-Liaison Psychiatry). The findings confirm longstanding speculation that the two conditions are linked."This highlights the need of a careful cardiac examination in patients with [panic disorder], many of which also suffer from MVP, ” wrote Umit Tural, M.D., and Dan V. Iosifescu, M.D., M.Sc., of The Nathan S. Kline Institute for Psychiatric R...
Source: Psychiatr News - August 20, 2019 Category: Psychiatry Tags: Academy of Consultation-Liaison Psychiatry agoraphobia mitral valve prolapse panic disorder Psychosomatics stroke sudden cardiac arrest Source Type: research
9798 —Hidradenitis suppurativa is associated with increased odds of stroke, coronary artery disease, heart failure, and PAD: A population-based analysis in the United States
Introduction: Hidradenitis suppurativa (HS) and psoriasis has been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
Dual Antiplatelet Therapy for High-Risk TIA and Minor Stroke: BMJ Rapid Recommendation.
PMID: 31524354 [PubMed - in process]
Source: American Family Physician - September 14, 2019 Category: Primary Care Authors: Croke L Tags: Am Fam Physician Source Type: research
Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins Biophysics and Computational Biology
Two mechanisms have been proposed for the function of motor proteins: The power stroke and the Brownian ratchet. The former refers to generation of a large downhill free energy gradient over which the motor protein moves nearly irreversibly in making a step, whereas the latter refers to biasing or rectifying...
Source: Proceedings of the National Academy of Sciences - September 30, 2019 Category: Science Authors: Wonmuk Hwang, Martin Karplus Tags: Perspective Source Type: research
An Unusual Cause of Stroke-Like Symptoms in an Elderly Patient.
PMID: 31737897 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - August 31, 2019 Category: General Medicine Authors: Kee CK, Ngam PI, Tan AP Tags: Ann Acad Med Singapore Source Type: research
Declining Stroke Mortality in Singapore and The Challenges Ahead.
PMID: 31875467 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - September 30, 2019 Category: General Medicine Authors: Hung J, De Silva DA, Seet RC Tags: Ann Acad Med Singapore Source Type: research
B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice Neuroscience
Lymphocytes infiltrate the stroke core and penumbra and often exacerbate cellular injury. B cells, however, are lymphocytes that do not contribute to acute pathology but can support recovery. B cell adoptive transfer to mice reduced infarct volumes 3 and 7 d after transient middle cerebral artery occlusion (tMCAo), independent of...
Source: Proceedings of the National Academy of Sciences - March 2, 2020 Category: Science Authors: Sterling B. Ortega, Vanessa O. Torres, Sarah E. Latchney, Cody W. Whoolery, Ibrahim Z. Noorbhai, Katie Poinsatte, Uma M. Selvaraj, Monica A. Benson, Anouk J. M. Meeuwissen, Erik J. Plautz, Xiangmei Kong, Denise M. Ramirez, Apoorva D. Ajay, Julian P. Meeks Tags: Biological Sciences Source Type: research
