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Total 125554 results found since Jan 2013.

Successfully Climbing the "STAIRs": Surmounting Failed Translation of Experimental Ischemic Stroke Treatments.
Authors: Kahle MP, Bix GJ Abstract The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the ...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Racial differences by ischemic stroke subtype: a comprehensive diagnostic approach.
Conclusions. We found similar proportions by race of cardioembolic and lacunar strokes when employing a full diagnostic evaluation including DWI MRI. The relatively high rate of cardioembolism may have been underappreciated in black stroke patients when employing a CT approach to stroke subtype diagnosis. Further research is required to better understand the racial differences in frequency of "stroke of other etiology" and explore disparities in the extent of diagnostic evaluations. PMID: 22645703 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Computed Tomography Identifies Patients at High Risk for Stroke After Transient Ischemic Attack/Nondisabling Stroke: Prospective, Multicenter Cohort Study Clinical Sciences
Conclusions— In patients with transient ischemic attack/nondisabling stroke, CT evidence of acute ischemia alone or acute ischemia with chronic ischemia or microangiopathy was associated with increased subsequent stroke risk within 90 days.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Wasserman, J. K., Perry, J. J., Sivilotti, M. L. A., Sutherland, J., Worster, A., Emond, M., Jin, A. Y., Oczkowski, W. J., Sahlas, D. J., Murray, H., MacKey, A., Verreault, S., Wells, G. A., Dowlatshahi, D., Stotts, G., Stiell, I. G., Sharma, M. Tags: Emergency treatment of Stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Subjective Memory Complaints and the Risk of Stroke Clinical Sciences
Conclusions— Subjective memory complaints might be an early indicator of stroke risk, especially in highly educated individuals.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Sajjad, A., Mirza, S. S., Portegies, M. L. P., Bos, M. J., Hofman, A., Koudstaal, P. J., Tiemeier, H., Ikram, M. A. Tags: Cerebrovascular disease/stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

The impact of stroke unit care on outcome in a Scottish stroke population, taking into account case mix and selection bias
Conclusions In routine practice, stroke unit admission is associated with a greater likelihood of discharge home and with lower mortality up to 1 year, after correcting for known independent predictors of outcome, and excluding early non-modifiable mortality.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 12, 2015 Category: Neurosurgery Authors: Turner, M., Barber, M., Dodds, H., Dennis, M., Langhorne, P., Macleod, M. J., on behalf of the Scottish Stroke Care Audit Tags: Open access, Stroke Cerebrovascular disease Source Type: research

Design and Validation of a Prehospital Scale to Predict Stroke Severity: Cincinnati Prehospital Stroke Severity Scale Clinical Sciences
Conclusions— CPSSS can identify stroke patients with NIHSS ≥15 and LVO. Prospective prehospital validation is warranted.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Katz, B. S., McMullan, J. T., Sucharew, H., Adeoye, O., Broderick, J. P. Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Behavioral Changes and Stroke, Emergency treatment of Stroke Clinical Sciences Source Type: research

Functional and Motor Outcome 5 Years After Stroke Is Equivalent to Outcome at 2 Months: Follow-Up of the Collaborative Evaluation of Rehabilitation in Stroke Across Europe Clinical Sciences
Conclusions— Five-year follow-up revealed deterioration in functional and motor outcome, with a return to the level measured at 2 months. Increasing age and increasing stroke severity negatively affected recovery up to 5 years after stroke.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Meyer, S., Verheyden, G., Brinkmann, N., Dejaeger, E., De Weerdt, W., Feys, H., Gantenbein, A. R., Jenni, W., Laenen, A., Lincoln, N., Putman, K., Schuback, B., Schupp, W., Thijs, V., De Wit, L. Tags: Exercise/exercise testing/rehabilitation, Behavioral Changes and Stroke Clinical Sciences Source Type: research

Objective fall risk detection in stroke survivors using wearable sensor technology: a feasibility study.
CONCLUSION: Stroke survivors reported high acceptability of 48 hours of continuous PAMSys monitoring. The use of in-home wearable technology may prove useful in monitoring fall risk and gait in stroke survivors, potentially enhancing recovery. PMID: 26382725 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 18, 2015 Category: Neurology Authors: Taylor-Piliae RE, Mohler MJ, Najafi B, Coull BM Tags: Top Stroke Rehabil Source Type: research

Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event Clinical Sciences
Conclusions— Patients currently treated with alteplase, despite a history of previous stroke ≤3 months, do not seem to achieve worse outcome than those with first-ever stroke. Although careful patient selection was probably of major importance, our findings provide reassurance that this group of patients may safely benefit from thrombolysis and should not be arbitrarily excluded as a whole. Further studies are needed to identify the shortest safe time lapse from the previous event to treatment with alteplase.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Karlinski, M., Kobayashi, A., Czlonkowska, A., Mikulik, R., Vaclavik, D., Brozman, M., Gdovinova, Z., Švigelj, V., Csiba, L., Fekete, K., Korv, J., Demarin, V., Bašic-Kes, V., Vilionskis, A., Jatuzis, D., Krespi, Y., Shamalov, N., Andonova, Tags: Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Plasma D-Dimer and Incident Ischemic Stroke and Coronary Heart Disease: The Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— A higher basal plasma d-dimer concentration in the general population is a risk marker for ischemic stroke, especially cardioembolic stroke.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Folsom, A. R., Gottesman, R. F., Appiah, D., Shahar, E., Mosley, T. H. Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Clinical Sciences Source Type: research

Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— SBI is present in 1 in 5 stroke-free older adults and is associated with a 2-fold increased risk of future stroke. Future studies of in-depth stroke risk evaluations and intensive prevention measures are warranted in patients with clinically unrecognized radiologically evident brain infarctions.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Gupta, A., Giambrone, A. E., Gialdini, G., Finn, C., Delgado, D., Gutierrez, J., Wright, C., Beiser, A. S., Seshadri, S., Pandya, A., Kamel, H. Tags: Primary Prevention, Risk Factors, Imaging, Magnetic Resonance Imaging (MRI), Ischemic Stroke Clinical Sciences Source Type: research

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke Clinical Sciences
Conclusions— Genetic variants that influence WMH are associated with an increased risk of lacunar stroke but not cardioembolic or large vessel stroke. Some genetic susceptibility factors seem to be shared across different radiological manifestations of small vessel disease.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Traylor, M., Rutten-Jacobs, L. C. A., Thijs, V., Holliday, E. G., Levi, C., Bevan, S., Malik, R., Boncoraglio, G., Sudlow, C., Rothwell, P. M., Dichgans, M., Markus, H. S. Tags: Genetic, Association Studies, Genetics, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale Clinical Sciences
Conclusions— Brief picture description analysis complements NIHSS scores in predicting stroke volume and location.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Agis, D., Goggins, M. B., Oishi, K., Oishi, K., Davis, C., Wright, A., Kim, E. H., Sebastian, R., Tippett, D. C., Faria, A., Hillis, A. E. Tags: Magnetic Resonance Imaging (MRI), Cognitive Impairment, Ischemic Stroke Clinical Sciences Source Type: research

Nocturnal Desaturation in the Stroke Unit Is Associated With Wake-Up Ischemic Stroke Clinical Sciences
Conclusions— Nocturnal desaturation was more frequently observed in patients admitted with WUS during the first night in the stroke unit. This suggests that nocturnal desaturation is a possible modifiable risk factor for the occurrence of WUS.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Kim, T. J., Ko, S.-B., Jeong, H.-G., Lee, J. S., Kim, C. K., Kim, Y., Nam, K., Mo, H., Joon An, S., Choi, H. A., Yoon, B.-W. Tags: Clinical Studies, Risk Factors, Ischemic Stroke Clinical Sciences Source Type: research

Hemoglobin Concentration and Risk of Incident Stroke in Community-Living Adults Clinical Sciences
Conclusions— Lower and higher hemoglobin concentrations were associated with a higher risk of incident stroke in women. No such associations were found in men.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Panwar, B., Judd, S. E., Warnock, D. G., McClellan, W. M., Booth, J. N., Muntner, P., Gutierrez, O. M. Tags: Clinical Studies, Epidemiology, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research