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Total 125554 results found since Jan 2013.

Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
ConclusionOur findings suggest that concomitant use of simvastatin with rivaroxaban may be associated with bleeding events in an Asian cohort. Further studies using physiologically based pharmacokinetic modelling are required to investigate the drug-drug interactions between these drugs.
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research

Post-Stroke Lateropulsion: Resolution and Function After Discharge From Inpatient Rehabilitation - A Cohort Study
CONCLUSIONS: Lateropulsion can continue to resolve after discharge from inpatient rehabilitation. Larger cohort studies are needed to further explore associations between persistent lateropulsion and long-term outcomes.PMID:37736404 | PMC:PMC10510537 | DOI:10.3138/ptc-2021-0078
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Jessica Nolan Erin Godecke Katrina Spilsbury Barbara Singer Source Type: research

PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research

The prevalence and prognosis of asymptomatic intracranial atherosclerosis in a community-based population: Results based on high-resolution magnetic resonance imaging
CONCLUSIONS: We found that ICAD detected using HR-MRI increases the long-term risk of a first-ever ischemic stroke in a stroke-free population, suggesting that the current primary prevention protocol of stroke awaits further optimization.PMID:37738517 | DOI:10.1111/ene.16057
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Shengde Li Mingyu Tang Dingding Zhang Fei Han Lixin Zhou Ming Yao Mingli Li Liying Cui Shuyang Zhang Bin Peng Zhengyu Jin Yicheng Zhu Jun Ni Source Type: research

PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research

Scoping Review on Brain-Computer Interface-Controlled Electrical Stimulation Interventions for Upper Limb Rehabilitation in Adults: A Look at Participants, Interventions, and Technology
CONCLUSIONS: Future BCI-ES interventional studies could address this gap. Additionally, standardization of device and rehabilitation modalities, and study-appropriate involvement with therapists, can be considered to advance this intervention towards clinical implementation.PMID:37736411 | PMC:PMC10510539 | DOI:10.3138/ptc-2021-0074
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Lazar I Jovanovic Hope Jervis Rademeyer Maureen Pakosh Kristin E Musselman Milos R Popovic Cesar Marquez-Chin Source Type: research

Dense dopaminergic innervation of the peri ‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post-stroke, potentially related to recovery. AbstractAfter ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri-infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrai...
Source: Journal of Neurochemistry - September 22, 2023 Category: Neuroscience Authors: Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A. Haas, Andreas Vlachos, Christian Schachtrup, Jonas A. Hosp Tags: ORIGINAL ARTICLE Source Type: research

Association Between Calcium Supplementation and the Risk of Cardiovascular Disease and Stroke: A  Systematic Review and Meta-Analysis
Some observational studies and randomised controlled trials (RCTs) have reported an association between calcium supplementation and increased risk of cardiovascular disease. Previous meta-analyses on the topic, based on data from RCTs and observational studies, have contradictory findings. This meta-analysis was conducted to determine the difference in associated risks of calcium supplementation with cardiovascular disease and stroke in RCTs.
Source: Heart, Lung and Circulation - September 22, 2023 Category: Cardiology Authors: Ming Gin Sim, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Tony Y.W. Li, Leonard L.L. Yeo, William K.F. Kong, Benjamin Y.Q. Tan, James W. Yip, Raymond C.C. Wong, Kian Keong Poh, Tiong-Cheng Yeo, Vijay Kumar Sharma, Ping Chai, Mark Y. Chan, Ching-Hui Sia Tags: Original Article Source Type: research

Refining the Detection of Systemic Congestion in Severe Tricuspid Regurgitation: Echocardiography May Be  the Key
A growing number of studies have shown the independent prognostic value of tricuspid regurgitation (TR) and the direct link between TR severity and adverse outcomes.1-4 However, TR not only affects prognosis but has also a negative impact on quality of life,5-7 decreasing functional capacity and increasing systemic congestion.7,8 The systolic blood backflow through the incompetent tricuspid valve reduces the forward stroke volume and cardiac output of the right ventricle (RV). Therefore, as TR worsens, pulmonary perfusion decreases, as does the venous return of oxygenated blood from the pulmonary circulation into the left ...
Source: Journal of the American Society of Echocardiography - September 22, 2023 Category: Cardiology Authors: Federico Fortuni, Nina Ajmone Marsan Tags: Editorial Source Type: research

Psychometric properties of the Chinese version of the Arm Activity Measure in people with chronic stroke
ConclusionsThe ArmA-C is reliable and valid for assessing active and passive functions in people with chronic stroke.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

Perceived performance of activities of daily living by stroke patients: key in decision to call EMS and outcomes
ConclusionPerception of unimpaired performance of ADL is a crucial barrier to appropriate help-seeking behavior after acute stroke, leading to undertreatment and less improvement in clinical symptoms. Thus, beyond improving the public’s knowledge of stroke symptoms, future public education campaigns should focus on the need for calling the EMS in case of stroke symptoms even if daily activities do not seem to be severely impaired.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk
Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dementia and multiple NCDs could be cost-effective and facilitate concurrent assessments as compared with a conventional single approach. The aim of this study is to develop and validate a new risk tool that estimates an individual’s risk of developing dementia and other NCDs including diabetes mellitus, stroke and myocardial infarction. Once validated, it could be used by the ...
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., Lautenschlager, N. T., Matthews, F., Shaw, J. E., Whitmer, R. A., Peters, R., Anstey, K. J. Tags: Open access, Public health Source Type: research

Health-related quality of life in stroke survivors: a 5-year follow-up of The Fall Study of Gothenburg (FallsGOT)
There are limited data on long-term prevalence and predictors of health-related quality of life (HRQoL) in stroke survivors. Therefore, the aim was to describe the prevalence of impaired HRQoL, and to identify...
Source: BMC Geriatrics - September 22, 2023 Category: Geriatrics Authors: M årten Segerdahl, Per-Olof Hansson, Carina M. Samuelsson and Carina U. Persson Tags: Research Source Type: research

Hemispheric Asymmetry in TMS-Induced Effects on Spatial Attention: A Meta-Analysis
AbstractHemispheric asymmetry is a fundamental principle in the functional architecture of the brain. It plays an important role in attention research where right hemisphere dominance is core to many attention theories. Lesion studies seem to confirm such hemispheric dominance with patients being more likely to develop left hemineglect after right hemispheric stroke than vice versa. However, the underlying concept of hemispheric dominance is still not entirely clear. Brain stimulation studies using transcranial magnetic stimulation (TMS) might be able to illuminate this concept. To examine the putative hemispheric asymmetr...
Source: Neuropsychology Review - September 22, 2023 Category: Neuroscience Source Type: research

Protocol for a single-blind randomized clinical trial to test the efficacy of bilateral transcranial magnetic stimulation on upper extremity motor function in patients recovering from stroke
No consensus currently exists regarding the optimal protocol for repetitive transcranial magnetic stimulation (rTMS) treatment of upper-extremity motor dysfunction after stroke. Studies have shown that combine...
Source: Trials - September 22, 2023 Category: General Medicine Authors: Yuan Huang, Ruizhu Lin, Hongyu Li, Yujuan Xu, Fubao Tian, Liangchen Ma, Xiaoli Liu, Shuming Ma, Xiaolong Li, Zheying Lai, Chuanping Bai, Weichun He, Qi Ma, Jingkai Wang and Ning Zhu Tags: Study protocol Source Type: research