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Drug: Melatonin

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Total 139 results found since Jan 2013.

The antioxidative property of melatonin against brain ischemia.
Authors: Paterniti I, Cordaro M, Esposito E, Cuzzocrea S Abstract This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction. Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N(1)-acetyl-N(2)-formyl-5- methoxykynuramine (AFMK) ...
Source: Expert Review of Neurotherapeutics - April 26, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Vitamin D Deficiency Is As Dangerous As Smoking
The advice you’re getting from your doctor, the TV and even the Surgeon General is so wrong, it’s scary. They’re all busy telling you to stay out of the sun. But Swedish researchers recently discovered that nonsmokers who avoid the sun have a life expectancy similar to smokers who spend a lot of time in the sun. Staying out of the sun is as dangerous as smoking.1 It doesn’t surprise me. I tell all my patients sunlight exposure is essential to our health because it is the best source of vitamin D… possibly the most important nutrient we know of. Mainstream medicine still doesn’t recognize th...
Source: Al Sears, MD Natural Remedies - May 19, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news

Why Every Woman Needs A Good Night's Rest
When I began writing in this spot three years ago, the headline of my very first entry was, "Getting Enough Sleep Is Smart, Not Selfish." That post went up at a time when Americans were beginning to focus more on a good night's rest. The subject came into a sharper focus, in part, because wearable technology gave us some specifics. Forget the anecdotal evidence of whether we slept well; with the touch of a button, we could know what time we fell asleep, how long we were out and how often our sleep was interrupted. The study of sleep -- and conversations around it -- began gaining traction. Among those paying keen attenti...
Source: Healthy Living - The Huffington Post - July 11, 2016 Category: Consumer Health News Source Type: news

Melatonin as an Antioxidant: Under Promises but Over Delivers
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 7, 2016 Category: Research Authors: Russel J. Reiter, Juan C. Mayo, Dun ‐Xian Tan, Rosa M. Sainz, Moises Alatorre‐Jimenez, Lilian Qin Tags: Review Source Type: research

Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices.
Abstract Therapeutic interventions on pathological processes involved in the ischemic cascade, such as oxidative stress, neuroinflammation, excitotoxicity and/or apoptosis, are of urgent need for stroke treatment. Melatonin regulates a large number of physiological actions and its beneficial properties have been reported. The aim of this study was to investigate whether melatonin mediates neuroprotection in rat hippocampal slices subjected to oxygen-glucose-deprivation (OGD) and glutamate excitotoxicity. Thus, we describe here that melatonin significantly reduced the amount of lactate dehydrogenase released in the...
Source: Neurotoxicology - September 8, 2016 Category: Neurology Authors: Patiño P, Parada E, Farré-Alins V, Molz S, Cacabelos R, Marco-Contelles J, López MG, Tasca CI, Ramos E, Romero A, Egea J Tags: Neurotoxicology Source Type: research

Sleep Deprivation Is Killing You And Your Career
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. The short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, emotional intelligence, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why You Need Adequate Sleep to Perform We've always...
Source: Healthy Living - The Huffington Post - September 17, 2016 Category: Consumer Health News Source Type: news

Protection of cardiac cell-to-cell coupling attenuate myocardial remodeling and proarrhythmia induced by hypertension.
Abstract Gap junction connexin channels are important determinants of myocardial conduction and synchronization that is crucial for coordinated heart function. One of the main risk factors for cardiovascular events that results in heart attack, congestive heart failure, stroke as well as sudden arrhythmic death is hypertension. Mislocalization and/or dysfunction of specific connexin-43 channels due to hypertension-induced myocardial remodeling have been implicated in the occurrence of life-threatening arrhythmias and heart failure in both, humans as well as experimental animals. Recent studies suggest that down-re...
Source: Physiological Research - September 18, 2016 Category: Physiology Authors: Egan Benova T, Szeiffova Bacova B, Viczenczova C, Diez E, Barancik M, Tribulova N Tags: Physiol Res Source Type: research

Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat
In this study, cerebral I/R injury rats were induced by middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion. The rats were randomly divided into 6 groups (12 rats per group): sham-operated; vehicle-treated I/R; 20 mg/kg, 40 mg/kg, and 80 mg/kg agomelatine-treated I/R; and 10 mg/kg melatonin-treated I/R. Agomelatine and melatonin were intraperitoneally administrated to the rats 1 h before MCAO induction. After reperfusion for 24 h, the brain samples were harvested for evaluating the infarct volume, histological changes, terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick-e...
Source: Neurochemistry International - December 22, 2016 Category: Neuroscience Source Type: research

Neuroendocrine abnormalities in Parkinson's disease
Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with multiple non-motor symptoms in PD and have important clinical consequences, including therapeutics. Some of the underlying mechanisms have been implicated in the pathogenesis of PD and represent promising targets for the development of disease biomarkers and neuroprotective therapies. In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Parkinson's di...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 12, 2017 Category: Neurosurgery Authors: De Pablo-Fernandez, E., Breen, D. P., Bouloux, P. M., Barker, R. A., Foltynie, T., Warner, T. T. Tags: Editor's choice, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke Movement disorders Source Type: research

Poor Sleep Hygiene Is Killing You And Your Career
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. According to the Division of Sleep Medicine at the Harvard Medical School, the short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why...
Source: Healthy Living - The Huffington Post - April 22, 2017 Category: Consumer Health News Source Type: news

Sleep Deprivation Is Killing You (And Making You Fat In The Process)
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. According to the Division of Sleep Medicine at the Harvard Medical School, the short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why...
Source: Healthy Living - The Huffington Post - June 24, 2017 Category: Consumer Health News Source Type: news

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury
AbstractIntracerebral hemorrhage (ICH) is a cerebrovascular disease with high mortality and morbidity, and the effective treatment is still lacking. We designed this study to investigate the therapeutic effects and mechanisms of melatonin on the secondary brain injury (SBI) after ICH. An in vivo ICH model was induced via autologous whole blood injection into the right basal ganglia in Sprague-Dawley (SD) rats. Primary rat cortical neurons were treated with oxygen hemoglobin (OxyHb) as an in vitro ICH model. The results of the in vivo study showed that melatonin alleviated severe brain edema and behavior disorders induced b...
Source: Translational Stroke Research - August 1, 2017 Category: Neurology Source Type: research

Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India
Conclusion: Greenness, ISA, and NTL were associated with increased SBP, DBP, and cPP, and with reduced FMD, suggesting a possible additional EVA pathway for the relationship between urbanization and increased CVD prevalence in urban India. https://doi.org/10.1289/EHP541 Received: 20 May 2016 Revised: 03 January 2017 Accepted: 23 January 2017 Published: 02 August 2017 Address correspondence to K.J. Lane, Yale School of Forestry and Environmental Studies, 195 Prospect Street, New Haven, CT 06511 USA. Telephone: (781) 696-4537; Email: kevin.lane@yale.edu Supplemental Material is available online (https://doi.org/10.1289...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The neuroprotective role of melatonin in neurological disorders
Abstract Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in some neurological conditions such as stroke, Alzheimer's disease, and Parkinson's disease, which indicates its involvement in the pathophysiology of these diseases. Its properties qualify it to be a promising potential therapeutic neuroprotective agent, with no side effects, for some neurological disorders. This review discusses and localizes the effect of melatonin in the pathophysiology of some diseases.
Source: Journal of Neuroscience Research - March 2, 2018 Category: Neuroscience Authors: B. S. Alghamdi Tags: REVIEW Source Type: research

Daylight Saving Time Starts Sunday. Here ’s What Losing An Hour of Sleep Really Does to Your Body
The start of Daylight Saving Time, when the clocks spring forward by an hour, is among the most hated days of the year. Aside from the obvious reason — losing an hour of sleep — research has shown that the time change, which this year falls on March 11, may contribute to everything from lost productivity to a heightened risk of heart attack and stroke. How can resetting your clocks do all that? TIME asked Dr. Cathy Goldstein, an assistant professor of neurology at the University of Michigan School of Medicine Sleep Disorders Center, what really happens to your body when you lose an hour of sleep for Daylight Sa...
Source: TIME: Health - March 9, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime sleep Source Type: news