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Drug: Melatonin
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Total 139 results found since Jan 2013.
Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B
Biochem Genet. 2021 Mar 11. doi: 10.1007/s10528-021-10045-y. Online ahead of print.ABSTRACTDiabetes shows high heritability and, worldwide, causes significant health problems including cardiovascular disease and stroke. There is significant variation in the frequency of diabetes between different populations. Both Cryptochromes and Melatonin have a major role to regulate the circadian clock. Circadian clock failure causes metabolic dysfunctions including diabetes and obesity. Variations in the Cryptochrome 1, the Cryptochrome 2, and the Melatonin receptor 1B (MTNR1B) genes show associations with fasting glucose, and are al...
Source: Biochemical Genetics - March 12, 2021 Category: Genetics & Stem Cells Authors: Issei Yoshiuchi Source Type: research
Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain
CONCLUSION: Conclusively, Mel is a potent biomaterial which could potentially impart neurogenesis through repairing impaired metabolic-redox circuit via enhanced TNT-mediated mitochondrial transfer, anti-oxidation, and anti-apoptotic activities in ischemia.PMID:33865018 | DOI:10.1016/j.biopha.2021.111593
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2021 Category: Drugs & Pharmacology Authors: Hon-Kan Yip Navneet Kumar Dubey Kun-Chen Lin Pei-Hsun Sung John Y Chiang Yi-Ching Chu Chi-Ruei Huang Yi-Ling Chen Yue-Hua Deng Hsin-Chung Cheng Win-Ping Deng Source Type: research
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway
Aging (Albany NY). 2021 Jun 11;13. doi: 10.18632/aging.203137. Online ahead of print.ABSTRACTDiabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelli...
Source: Aging - June 12, 2021 Category: Biomedical Science Authors: Lian Liu Quan Cao Wenwei Gao Bingyu Li Zhongyuan Xia Bo Zhao Source Type: research
Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss
Cell Mol Neurobiol. 2021 Jul 1. doi: 10.1007/s10571-021-01122-2. Online ahead of print.ABSTRACTThe only food and drug administration (FDA)-approved drug currently available for the treatment of acute ischemic stroke is tissue plasminogen activator (tPA), yet the therapeutic benefits of this drug are partially outweighed by the increased risk of hemorrhagic transformation (HT). Analysis of the NIH trial has shown that cigarette smoking protected tPA-treated patients from HT; however, the underlying mechanism is not clear. Nicotinic acetylcholine receptors (nAChR) has shown anti-inflammatory effect and modulation nAChR could...
Source: Cellular and Molecular Neurobiology - July 1, 2021 Category: Cytology Authors: Shuang Chen Yanyun Sun Fei Li Xinyu Zhang Xiaoyan Hu Xiaoyun Zhao Yixuan Li Hui Li Jianliang Zhang Wenlan Liu Guo-Qing Zheng Xinchun Jin Source Type: research
Agomelatine Exerts an Anti-inflammatory Effect by Inhibiting Microglial Activation Through TLR4/NLRP3 Pathway in pMCAO Rats
In this study, we aimed to investigate the anti-inflammatory effect of agomelatine in a permanent middle cerebral artery occlusion (pMCAO) model. Forty-eight male Wistar rats were randomly divided into four groups: sham, pMCAO + vehicle, pMCAO + agomelatine (40 mg/kg, i.p.), and pMCAO + melatonin (10 mg/kg, i.p.) groups. On day 1 after permanent cerebral ischemia, the animals were sacrificed, and brain tissues were collected for western blot analysis, and immunohistochemistry. Agomelatine treatment ameliorated inflammatory responses by decreasing the protein levels of trigger Toll-like receptor (TLR4)/nuclear factor kappa-...
Source: Cell Research - November 29, 2021 Category: Cytology Authors: Wijitra Chumboatong Satchakorn Khamchai Chainarong Tocharus Piyarat Govitrapong Jiraporn Tocharus Source Type: research
REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications Commentary
ConclusionsThe clinical and research RBD fields span across the disciplines of neurology, pulmonary, psychiatry, psychology, and pediatric sleep medicine, along with physical medicine and rehabilitation medicine, other allied disciplines, and the basic and clinical neurosciences.
Source: Sleep and Breathing - March 3, 2022 Category: Respiratory Medicine Source Type: research
Correction to: Electroacupuncture Ameliorates Cognitive Impairment Through the Inhibition of NLRP3 Inflammasome Activation by Regulating Melatonin-Mediated Mitophagy in Stroke Rats
Neurochem Res. 2022 Mar 31. doi: 10.1007/s11064-022-03590-4. Online ahead of print.NO ABSTRACTPMID:35357601 | DOI:10.1007/s11064-022-03590-4
Source: Neurochemical Research - March 31, 2022 Category: Neuroscience Authors: Xiaoyong Zhong Bin Chen Zuanfang Li Ruhui Lin Su Ruan Fang Wang Hui Liang Jing Tao Source Type: research
What the Science Says About the Health Benefits of Vitamins and Supplements
From multivitamins and melatonin to fiber and fish oil, Americans who are trying to boost their health and immunity have a plethora of supplements to choose from. An estimated 58% of U.S. adults ages 20 and over take dietary supplements, according to the U.S. Centers for Disease Control and Prevention, and the supplement industry is valued at more than $30 billion a year. Supplement use has been growing rapidly over the past few decades along with the wellness industry.
“The popular belief is that a supplement is going to be helpful for promoting health,” says Fang Fang Zhang, a professor at Tufts University&rs...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news
