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Drug: Melatonin

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Total 139 results found since Jan 2013.

What Medications Prevent Delirium in Elderly Medical Inpatients?
This study demonstrated lower rates of delirium in the melatonin arm, with an impressive number needed to treat (NNT) below six patients; mortality and length of hospital stay were unaffected.3 A delirium-prevention effect of melatonin has not been reproduced in other studies, notably Jaiswal et al, which randomized patients to a placebo or 3 mg of melatonin and found no difference in rates of delirium prevention.7  The melatonin receptor agonist ramelteon also has small but favorable evidence for preventing non-ICU hospitalized delirium. This comes from a study of 67 patients aged 65 years or older who were randomized to...
Source: The Hospitalist - May 2, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Drug Therapy Geriatrics Key Clinical Questions Medication Source Type: research

Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research

Melatonin mitigates type 1 diabetes ‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects
ConclusionsT1DM aggravates CIRI. Melatonin treatment is neuroprotective against CIRI in T1DM rats via anti-inflammatory and anti-apoptotic effects.
Source: Brain and Behavior - June 16, 2023 Category: Neurology Authors: Qian Xu, Raymond Tak Fai Cheung Tags: ORIGINAL ARTICLE Source Type: research

Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
(Cell Transplantation Center of Excellence for Aging and Brain Repair) Melatonin used as a pre-treatment for mesenchymal stem cells, prior to their transplantation into the brains of laboratory animals to repair damage from stroke, helped stem cells survive longer after transplantation. The melatonin pre-treatment greatly increased cell survival when contrasted with previous studies in which 80 percent of transplanted MSCs died within 72 hours of transplantation. Study results demonstrated that the melatonin pre-treated MSCs had enhanced survival under oxidative stimulation by activating the Erk1/2 pathway.
Source: EurekAlert! - Medicine and Health - July 22, 2013 Category: Global & Universal Source Type: news

Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin
This study was designed to evaluate the time course of expression of the Nox family, a major source of ROS, and whether melatonin, a potent scavenger of ROS, influences these parameters in a rat model of cerebral I/R caused by middle cerebral artery occlusion (MCAO). After 2 h occlusion, the filament was withdrawn to allow reperfusion. At 0 h, 3 h, 6 h, 12 h, 24 h and 48 h after reperfusion, brain tissue samples were obtained for assays. Among the Nox family, the mRNA and protein levels of Nox2 and Nox4 were increased both in the ischemic hemisphere and contralateral counterpart in the experimental I/R rats at 0 h after ...
Source: Journal of Pineal Research - May 1, 2014 Category: Research Authors: Haiying Li, Yang Wang, Dongxia Feng, Yin Liu, Min Xu, Anju Gao, Fengxuan Tian, Li Zhang, Yonghua Cui, Zhong Wang, Gang Chen Tags: Original Article Source Type: research

The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia.
Abstract Melatonin is produced and released by the pineal gland in a circadian rhythm. This neurohormone has proven to be an antioxidant and anti-inflammatory molecule able to reduce or mitigate cell damage associated with oxidative stress and inflammation, and this phenomenon underlies neurodegenerative disorders. These facts have drawn attention to this indole,triggering interest in evaluating its changes and in its relationship to the processes indicated, and analyzing its role in the mechanisms involved at the onset and development of neurodegenerative diseases, as well as its therapeutic potential. Multiple s...
Source: CNS and Neurological Disorders Drug Targets - August 6, 2014 Category: Drugs & Pharmacology Authors: Escribano BM, Colín-González AL, Santamaría A, Tunez I Tags: CNS Neurol Disord Drug Targets Source Type: research

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1‐dependent mechanism during ischemic‐stroke in mice
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - November 17, 2014 Category: Research Authors: Yang Yang, Shuai Jiang, Yushu Dong, Chongxi Fan, Lei Zhao, Xiangmin Yang, Juan Li, Shouyin Di, Liang Yue, Guobiao Liang, Russel J Reiter, Yan Qu Tags: Original Article Source Type: research

Stroke and pineal gland calcification: Lack of association. Results from a population-based study (The Atahualpa Project)
The pineal gland has been the subject of myths and misconceptions over the years. These ranged from the ancient belief that it is the “seat of the soul” (René Descartes, 1596-1650), to more recent hypotheses suggesting that pineal dysfunction is associated with sense of direction loss [1] or that calcifications of the gland are less prevalent in underdeveloped societies [2]. Current knowledge indicates that the main function of the pineal gland is to secrete melatonin, a hormone primarily associated with timing of circadian rhythms and control of the sleep-wake cycle [3].
Source: Clinical Neurology and Neurosurgery - January 5, 2015 Category: Neurosurgery Authors: Oscar H. Del Brutto, Robertino M. Mera, Julio Lama, Mauricio Zambrano Source Type: research

The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study)
Introduction Blue light information plays an important role in synchronising internal biological rhythm within the external environment. Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear...
Source: BMJ Open - May 12, 2015 Category: Journals (General) Authors: Nishi, T., Saeki, K., Obayashi, K., Miyata, K., Tone, N., Tsujinaka, H., Yamashita, M., Masuda, N., Mizusawa, Y., Okamoto, M., Hasegawa, T., Maruoka, S., Ueda, T., Kojima, M., Matsuura, T., Kurumatani, N., Ogata, N. Tags: Open access, Epidemiology, Ophthalmology Protocol Source Type: research

7 Big Things We Learned About Sleep In The Past Decade
It's no secret that here at The Huffington Post, we love sleep -- and for good reason. Sleep has been called the "third pillar" of health, along with nutrition and exercise. Getting the quality sleep that you need has the power to protect your physical and mental health, while skipping out on sleep can seriously hurt your health, cognition and well-being over time. Over the past 10 years, sleep has finally become widely recognized as a critical aspect of good health, and new research has shed more light on its importance in our lives. Here's what we've learned. 1. A sleeping brain is an active brain. While you're re...
Source: Science - The Huffington Post - May 25, 2015 Category: Science Source Type: news

Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats
Melatonin, N-aceyl-5-methoxytryptamine, is the main secretory product of the pineal gland and has neuroprotective effects on several brain injuries including ischemic stroke. In the present study, we hypothesized that exogenous melatonin may decrease hypoglycemia-induced neuronal death through prevention of superoxide generation. To test our hypothesis, hypoglycemia was induced by injecting human insulin (10 U/kg, ip) in rats. Melatonin injection was started immediately after hypoglycemia (10 mg/kg, ip). The first melatonin injection was performed at the end of a 30-min isoelectric EEG period. The second and third injectio...
Source: Neuroendocrinology - June 10, 2015 Category: Endocrinology Source Type: research

Lessons Learned From Trends in Insufficient Sleep Across the United States
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - October 16, 2015 Category: Consumer Health News Source Type: news

10 Sleep Technologies: How Much Snore for the Dollar?
Do you want better sleep? Of course you do. You know how bad it is to miss out on sleep, so it can feel like insult added to injury to read yet another newfound, devastating consequence of insufficient sleep: heart disease, heart attack, high blood pressure, stroke, diabetes, mental impairment, etc. And the list is expanding almost daily as researchers learn more. There are "easy" actions that may aid with sleep. Relaxation activities like meditation or chamomile tea are useful for some. Setting and sticking to a waking and sleeping schedule, creating a bedroom retreat, and making a list of worries before turning in can he...
Source: Healthy Living - The Huffington Post - October 27, 2015 Category: Consumer Health News Source Type: news

Ice Pick Headache
Abstract Ice pick headache, also called idiopathic or primary stabbing headache, is a unique headache type associated with ultra-brief stabs of pain, most commonly in the frontal or temporal area. It occurs predominantly in women and is estimated to affect 2–35 % of the population. Unlike other headache types of short duration, such as short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), ice pick headache is not associated with any cranial autonomic symptoms but has been known to occur with nausea, vomiting, photophobia, and dizziness. It exists in two forms: primary ...
Source: Current Pain and Headache Reports - April 1, 2016 Category: Neurology Source Type: research