Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation

(Cell Transplantation Center of Excellence for Aging and Brain Repair) Melatonin used as a pre-treatment for mesenchymal stem cells, prior to their transplantation into the brains of laboratory animals to repair damage from stroke, helped stem cells survive longer after transplantation. The melatonin pre-treatment greatly increased cell survival when contrasted with previous studies in which 80 percent of transplanted MSCs died within 72 hours of transplantation. Study results demonstrated that the melatonin pre-treated MSCs had enhanced survival under oxidative stimulation by activating the Erk1/2 pathway.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news