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Drug: Lipitor
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Total 875 results found since Jan 2013.
Atorvastatin inhibits miR-143 expression: A protective mechanism against oxidative stress in cardiomyocytes
Statins are unequivocally the most widely prescribed drug for the primary and secondary prevention of coronary artery disease worldwide [1]. Atorvastatin is the most commonly prescribed statin drug due to its lower therapeutic dose comared to others. The well-tolerated and high benefit–risk ration of atorvastain has been demonstrated in clinical trials [2]. Atorvastatin reduce the risk of myocardial infarction, stroke, and death, primarily inhibiting reactive oxygen species (ROS) [3].
Source: International Journal of Cardiology - March 1, 2016 Category: Cardiology Authors: Shanshan Tian, Wei Zhao, Di Yang, Yang Yu, Jiaqi Zou, Zhiyan Liu, Zhimin Du Tags: Correspondence Source Type: research
New drug 'effective' for those with intolerable statin side effects
Conclusion
The main results of this study relate to the lipid-lowering effects of two alternative non-statin medications. However, it highlights the muscle-related adverse effects that can occur with statins.
The study is carefully designed and has many strengths, including:
a washout period between drugs to remove any residual effects
double-blind design throughout so people didn't know what they were taking
sufficient duration for each phase of the study (10 and 24 weeks) to allow effects to develop
a good sample size – the researchers calculated beforehand how many people would need to be recruited to ena...
Source: NHS News Feed - April 4, 2016 Category: Consumer Health News Tags: Heart/lungs Medication Older people Source Type: news
Comparative Effectiveness of Generic Atorvastatin and Lipitor(R) in Patients Hospitalized with an Acute Coronary Syndrome Health Services and Outcomes Research
Conclusions
Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor® at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and health care plans without diminishing population clinical effectiveness.
Source: JAHA:Journal of the American Heart Association - April 18, 2016 Category: Cardiology Authors: Jackevicius, C. A., Tu, J. V., Krumholz, H. M., Austin, P. C., Ross, J. S., Stukel, T. A., Koh, M., Chong, A., Ko, D. T. Tags: Atrial Fibrillation, Quality and Outcomes Health Services and Outcomes Research Source Type: research
In this Issue
The 4D Study was a randomized trial comparing 4 years of treatment with atorvastatin to placebo in 1255 hemodialysis patients with type 2 diabetes. In the original trial, atorvastatin did not significantly reduce the primary end point of cardiovascular events, including cardiac death, myocardial infarction, and stroke. To determine the long-term effects of atorvastatin in these patients, Krane and co-workers used questionnaires to assess clinical outcomes in surviving 4D participants. After median follow-up of 11.5 years, participants who had been assigned to atorvastatin had a nonsignificant trend toward fewer cardiovascu...
Source: Kidney International - May 13, 2016 Category: Urology & Nephrology Tags: In this Issue Source Type: research
Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke
10.3109/00207454.2016.1146882Jingmiao Zhang
Source: International Journal of Neuroscience - February 21, 2016 Category: Neuroscience Authors: Jingmiao ZhangXiali MuDane A BrekerYing LiZongliang GaoYonglu Huang Source Type: research
Interpretation of the evidence for the efficacy and safety of statin therapy
Publication date: Available online 8 September 2016 Source:The Lancet Author(s): Rory Collins, Christina Reith, Jonathan Emberson, Jane Armitage, Colin Baigent, Lisa Blackwell, Roger Blumenthal, John Danesh, George Davey Smith, David DeMets, Stephen Evans, Malcolm Law, Stephen MacMahon, Seth Martin, Bruce Neal, Neil Poulter, David Preiss, Paul Ridker, Ian Roberts, Anthony Rodgers, Peter Sandercock, Kenneth Schulz, Peter Sever, John Simes, Liam Smeeth, Nicholas Wald, Salim Yusuf, Richard Peto This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention...
Source: The Lancet - September 8, 2016 Category: Journals (General) Source Type: research
Involvement of peroxisome proliferator activated receptor- γ in the anti-inflammatory effects of atorvastatin in oxygen-glucose deprivation/reperfusion-stimulated RAW264.7 murine macrophages.
Involvement of peroxisome proliferator activated receptor-γ in the anti-inflammatory effects of atorvastatin in oxygen-glucose deprivation/reperfusion-stimulated RAW264.7 murine macrophages.
Mol Med Rep. 2016 Sep 15;
Authors: Li HY, Su YY, Zhang YF, Liu ZQ, Hua BJ
Abstract
Ischemia‑reperfusion (I/R) injury is important in the pathogenesis and/or progression of various diseases, including stroke, cardiovascular disease and acute renal injury. Increasing evidence indicates that atorvastatin exerts protective effects in I/R injury‑associated diseases; however, the underlying mechanisms remain to be f...
Source: Molecular Medicine Reports - September 19, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study
Conclusions
High Lp(a) concentrations and LMW apo(a) isoforms are risk predictors for all-cause mortality and death due to infection in haemodialysis patients with diabetes mellitus. These associations are modified by age.
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Kollerits, B., Drechsler, C., Krane, V., Lamina, C., März, W., Dieplinger, H., Ritz, E., Wanner, C., Kronenberg, F., for the German Diabetes and Dialysis Study Investigators Tags: Chronic Kidney Disease Source Type: research
Intracranial dermoid cyst rupture-related brain ischemia: Case report and hemodynamic study
Rationale: Spontaneous rupture of intracranial dermoid cyst is a rare but serious clinical event that can result in cerebral ischemia. Cerebral vasospasm and vasculitis are considered as potential mechanisms of dermoid cyst rupture-related cerebral ischemia. However, the hemodynamic mechanisms between cerebral ischemia and dermoid cyst rupture are not well known.
Patient concerns: A 55-year-old, right-handed man was admitted to our hospital with sudden receptive aphasia and right-sided hypoalgesia. Brain magnetic resonance imaging (MRI) revealed a ruptured dermoid cyst and watershed infarcts in the left hemisphere. Then b...
Source: Medicine - January 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Hemopericardium under dabigatran for stroke prevention in atrial fibrillation
We report a polymorbid 75-year old male under a therapy with dabigatran, valsartan, amlodipine, nicorandil, furosemide, atorvastatin, bisoprolol, metformin, tizanidine, pantoprazole, and tramadol. He suffered from chest pain for 4 months. Coronary angiography showed only ectatic coronary arteries. He started taking nonsteroidal anti-inflammatory drugs. He was hospitalized because of dyspnea starting 10 days before admission, melena, and renal failure. Hemopericardium was diagnosed and pericardiocentesis yielded 2000 ml hemorrhagic fluid. Review of previous echocardiograms showed a 4 mm echo-free space, epicardial fat o...
Source: Blood Coagulation and Fibrinolysis - February 11, 2017 Category: Hematology Tags: Case Reports Source Type: research
Atorvastatin inhibits cholesterol-induced caspase-3 cleavage through down-regulation of p38 and up-regulation of Bcl-2 in the rat carotid artery.
CONCLUSIONS: The resultant data suggest that the anti-apoptotic effect of AV could be partially mediated by the pro-inflammatory protein p38 MAPK and the anti-apoptotic protein Bcl-2 in the rat carotid artery. Atorvastatin can therefore be considered a target drug in the prevention or development of atherosclerotic events.
PMID: 28498386 [PubMed - as supplied by publisher]
Source: Cardiovascular Journal of Africa - May 5, 2017 Category: Cardiology Authors: Bayatmakoo R, Rashtchizadeh N, Yaghmaei P, Farhoudi M, Karimi P Tags: Cardiovasc J Afr Source Type: research
The short term effect of atorvastatin plus ezetimibe therapy vs. atorvastatin monotherapy on clinical outcome in the acute coronary syndrome patients by gender.
CONCLUSIONS: The results of our study demonstrated that when added to statin therapy, EZE resulted in improved cardiovascular outcomes and the response to atorvastatin and EZE combination was similar for both men and women.
PMID: 28553847 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - May 29, 2017 Category: Cardiology Authors: Japaridze L, Sadunishvili M Tags: Kardiol Pol Source Type: research
Spontaneous recanalization of atherosclerotic middle cerebral artery occlusion: Case report
Rationale: Intracranial vascular atherosclerotic occlusion is one of the most common causes of ischemic stroke world wide. The involvement of large intracranial vessels, in particular, the middle cerebral artery, is usually associated with unfavorable outcomes in patients. Spontaneous recanalization of atherosclerotic occlusion is relatively rare.
Patient concerns: The first patient was a 43-year-old male with slurred speech and left-sided weakness for a duration of 24 hours. The second was a 59-year-old male with left-sided weakness over a period of 13 hours. The last was a 49-year-old female patient presented with a...
Source: Medicine - July 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
High-intensity Statin Treatments in Clinically Stable Patients on Aspirin Monotherapy 12 Months After Drug-eluting Stent Implantation: A Randomized Study
Conclusions Among clinically stable DES-treated patients on aspirin monotherapy, high-intensity statin treatment significantly reduced late adverse events compared with low-intensity statin treatment. Clinical trial registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01557075.
Source: Revista Espanola de Cardiologia - July 15, 2017 Category: Cardiology Source Type: research
