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Drug: Lipitor
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Total 875 results found since Jan 2013.
Assessment of Lipophilic vs. Hydrophilic Statin Therapy in Acute Myocardial Infarction.
Conclusions:On 2-year comparison of hydrophilic and lipophilic statins there was no significant difference in prevention of secondary cardiovascular outcome.
PMID: 25392071 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 12, 2014 Category: Cardiology Authors: Izawa A, Kashima Y, Miura T, Ebisawa S, Kitabayashi H, Yamamoto H, Sakurai S, Kagoshima M, Tomita T, Miyashita Y, Koyama J, Ikeda U Tags: Circ J Source Type: research
Differential Effects of Strong and Regular Statins on the Clinical Outcome of Patients With Chronic Kidney Disease Following Coronary Stent Implantation.
Conclusions:In patients with mild-to-moderate CKD, only strong statins were associated with lower risk compared with no statin, but regular statins were not. It is possible that taking a strong statin from the early stage of CKD is useful for suppression of cardiovascular events.
PMID: 25739954 [PubMed - as supplied by publisher]
Source: Circulation Journal - February 24, 2015 Category: Cardiology Authors: Ishii M, Hokimoto S, Akasaka T, Fujimoto K, Miyao Y, Kaikita K, Oshima S, Nakao K, Shimomura H, Tsunoda R, Hirose T, Kajiwara I, Matsumura T, Nakamura N, Yamamoto N, Koide S, Oka H, Morikami Y, Sakaino N, Matsui K, Ogawa H, on behalf of the Kumamoto Inter Tags: Circ J Source Type: research
High dose atorvastatin therapy yields a better carotid atherosclerosis improvement in Chinese patients
Statins is one of key components in the cocktail of medications for the treatment of patients with atherosclerosis and have proved to reduce vascular events significantly in primary and secondary prevention of coronary heart disease (CHD) in the past decades [1–3]. As the most widely used statins, the effectiveness of atorvastatin in lowering LDL-C has been demonstrated in several trials [4,5]. Plasma LDL-C levels and carotid intima-media thickness (IMT) have been proved associated with incidence of stroke [6].
Source: International Journal of Cardiology - March 11, 2015 Category: Cardiology Authors: Yafeng Li, Shoucui Gao, Yingfeng An, Enqi Liu, Sihai Zhao Source Type: research
Cholesterol – the super-stealthy invisible illness
Sourced from The Hysterectomy Association: Hysterectomy Association - Hysterectomy Association - hysterectomy, menopause and hormone replacement therapy (hrt) information and support for women.
As far as invisible illnesses go, they don’t come much stealthier than high cholesterol. It’s easily ignored because it builds up gradually, often showing no symptoms whatsoever. A person with high or increasing cholesterol levels will most likely feel perfectly healthy. It’s a scary though that the first sign of high cholesterol may be a heart attack or stroke – and could even prove fatal!
Fortunately, medical professionals...
Source: The Hysterectomy Association - March 26, 2015 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health Conditions cholesterol invisible illness Source Type: news
Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy The TNT Trial
ConclusionsElevated OxPL-apoB levels predict secondary MACE in patients with stable CHD, a risk that is mitigated by atorvastatin 80 mg. (A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels [TNT]; NCT00327691)
Source: Journal of the American College of Cardiology - March 30, 2015 Category: Cardiology Source Type: research
Excessive range of statin dose in Western Australian primary care
ConclusionThe extraordinarily wide variation in statin dose is at odds with the more consistent doses of other drugs used in the management of arterial disease. Unnecessarily high statin dosing increases side effects and may not improve clinical outcomes appreciably. Rational prescribing of statins based on the pharmacodynamic evidence, with lower doses in most patients, combined with close attention to reduction of smoking, blood pressure and weight is likely to reduce arterial disease most efficiently and safely.
Source: Internal Medicine Journal - April 14, 2015 Category: Internal Medicine Authors: SB Dimmitt, A Moran, M Scartozzi, HG Stampfer, JB Warren Tags: Original Article Source Type: research
Fasting Triglycerides Predict Recurrent Ischemic Events in Patients With Acute Coronary Syndrome Treated With Statins
ConclusionsAmong patients with ACS treated effectively with statins, fasting triglycerides predict long-term and short-term cardiovascular risk. Triglyceride-rich lipoproteins may be an important additional target for therapy. (A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome; NCT00658515)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - May 25, 2015 Category: Radiology Source Type: research
Statin Drugs and Prostate Cancer
Statin drugs are a group of widely prescribed ones used to lower a person's cholesterol level. Common statin medications include brands such as Lipitor, Crestor and Zocar. Statins work by inhibiting an enzyme in the human body, 'HMG-CoA reductase,' which is used to manufacture cholesterol and the drugs may also help to clear already formed cholesterol from the bloodstream. High cholesterol is a known cause of cardiovascular disease and it is well-established that statins reduce the rate of illness and death caused by cardiovascular disease. While statins can help to prevent the risk of a stroke or heart attack, some studie...
Source: Disabled World - June 8, 2015 Category: Disability Tags: Pharmaceutical - Drug Information Source Type: news
Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibition RESEARCH ARTICLE
ABSTRACT
Myocardial infarction and stroke are frequent after surgical procedures and consume a considerable amount of benefit of surgical therapy. Perioperative stress, induced by surgery, is composed of hemodynamic and inflammatory reactions. The effects of perioperative stress on atherosclerotic plaques are ill-defined. Murine models to investigate the influence of perioperative stress on plaque stability and rupture are not available. We developed a model to investigate the influence of perioperative stress on plaque growth and stability by exposing apolipoprotein-E-deficient mice, fed a high cholesterol diet for 7 ...
Source: DMM Disease Models and Mechanisms - August 27, 2015 Category: Biomedical Science Authors: Janssen, H., Wagner, C. S., Demmer, P., Callies, S., Solter, G., Loghmani-khouzani, H., Hu, N., Schuett, H., Tietge, U. J. F., Warnecke, G., Larmann, J., Theilmeier, G. Tags: RESEARCH ARTICLE Source Type: research
Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese zucker rats.
This study determined the structural and functional changes to the middle cerebral arteries (MCA) during the progression of MetS, and the effects of chronic pharmacological interventions on mitigating vascular alterations in obese Zucker rats (OZR), a translationally-relevant model of MetS. The reactivity and wall mechanics of ex vivo pressurized MCA from lean Zucker rats (LZR) and OZR was determined at 7-8, 12-13 and 16-17 weeks of age under control conditions and following chronic treatment with pharmacological agents targeting specific systemic pathologies. With increasing age, control OZR demonstrated reduced nitric ox...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 16, 2015 Category: Physiology Authors: Brooks SD, DeVallance E, d'Audiffret AC, Frisbee SJ, Tabone LE, Shrader CD, Frisbee JC, Chantler PD Tags: Am J Physiol Heart Circ Physiol Source Type: research
Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial
Conclusion
The infrastructure of GCS and the primary health care system in Iran enabled the conduct of this pragmatic large-scale trial. If the polypill strategy proves effective, it may be implemented to prevent cardiovascular disease in developing countries.
Source: European Journal of Preventive Cardiology - November 9, 2015 Category: Cardiology Authors: Ostovaneh, M. R., Poustchi, H., Hemming, K., Marjani, H., Pourshams, A., Nateghi, A., Majed, M., Navabakhsh, B., Khoshnia, M., Jaafari, E., Mohammadifard, N., Malekzadeh, F., Merat, S., Sadeghi, M., Naemi, M., Etemadi, A., Thomas, G. N., Sarrafzadegan, N. Tags: Original scientific paper Source Type: research
Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese Zucker rats
This study determined the structural and functional changes in the middle cerebral arteries (MCA) during the progression of MetS and the effects of chronic pharmacological interventions on mitigating vascular alterations in obese Zucker rats (OZR), a translationally relevant model of MetS. The reactivity and wall mechanics of ex vivo pressurized MCA from lean Zucker rats (LZR) and OZR were determined at 7–8, 12–13, and 16–17 wk of age under control conditions and following chronic treatment with pharmacological agents targeting specific systemic pathologies. With increasing age, control OZR demonstrated r...
Source: AJP: Heart and Circulatory Physiology - December 1, 2015 Category: Cardiology Authors: Brooks, S. D., DeVallance, E., d'Audiffret, A. C., Frisbee, S. J., Tabone, L. E., Shrader, C. D., Frisbee, J. C., Chantler, P. D. Tags: CALL FOR PAPERS Source Type: research
Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study
In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35–3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36–6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16–2.07), and acute ischemic ...
Source: Medicine - January 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Relation Between Change in Renal Function and Cardiovascular Outcomes in Atorvastatin-Treated Patients (From the Treating to New Targets TNT Study)
Statins may have nephroprotective as well as cardioprotective effects in patients with cardiovascular disease. In the Treating to New Targets (TNT) study (NCT00327691), patients with coronary heart disease (CHD) were randomized to atorvastatin 10- or 80-mg/day and followed for 4.9 years. The relationship between intra-study change in estimated glomerular filtration rate (eGFR) from baseline and the risk of major cardiovascular events (MCVE, defined as CHD death, nonfatal non-procedure-related myocardial infarction, resuscitated cardiac arrest or fatal or nonfatal stroke) was assessed among 9500 patients stratified by renal...
Source: The American Journal of Cardiology - January 28, 2016 Category: Cardiology Authors: James Shepherd, Andrei Breazna, Prakash C. Deedwania, John C. LaRosa, Nanette K. Wenger, Michael Messig, Daniel J. Wilson, Treating to New Targets Steering Committee and Investigators Source Type: research
Long-term effects following 4 years of randomized treatment with atorvastatin in patients with type 2 diabetes mellitus on hemodialysis
The 4D (Die Deutsche Diabetes Dialyse) Study was a randomized, double-blind trial comparing 4 years of treatment with atorvastatin to placebo in 1255 hemodialysis patients with type 2 diabetes. The primary end point of cardiovascular events (cardiac death, myocardial infarction, and stroke) was non-significantly reduced by 8%. However, long-term effects remained uncertain. Therefore, surviving patients were invited to a follow-up survey done by questionnaire. Post-trial statin therapy was at nephrologist discretion, and outcomes were centrally adjudicated and analyzed by intention to treat and time to first event in the or...
Source: Kidney International - February 17, 2016 Category: Urology & Nephrology Authors: Vera Krane, Kay-Renke Schmidt, Lena J. Gutjahr-Lengsfeld, Johannes F.E. Mann, Winfried März, Florian Swoboda, Christoph Wanner, 4D Study Investigators (the German Diabetes and Dialysis Study Investigators) Tags: Clinical Trial Source Type: research
