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Total 478 results found since Jan 2013.

Posterior reversible encephalopathy syndrome: an acute manifestation of systemic lupus erythematous.
Abstract Stroke mimickers are common, and they represent a diagnostic dilemma for clinicians. Many, like posterior reversible encephalopathy syndrome (PRES), are easily reversible. The manifestation of PRES is characterised by headaches, convulsions, altered mental functioning and blindness. In most cases, computed tomography of the brain will show hypodense lesions in the parieto-occpitial lobe, which only further confounds the physician. Although this syndrome is uncommon, prompt and accurate recognition allows early treatment, which has been shown to produce favourable outcomes. Herein, we report the case of a ...
Source: Singapore Medical Journal - September 1, 2013 Category: Journals (General) Authors: Chan MJ, Ong YS Tags: Singapore Med J Source Type: research

The use of virtual reality-based therapy to augment poststroke upper limb recovery.
Abstract Stroke remains one of the major causes of disability worldwide. This case report illustrates the complementary use of biomechanical and kinematic in-game markers, in addition to standard clinical outcomes, to comprehensively assess and track a patient's disabilities. A 65-year-old patient was admitted for right-sided weakness and clinically diagnosed with acute ischaemic stroke. She participated in a short trial of standard stroke occupational therapy and physiotherapy with additional daily virtual reality (VR)-based therapy. Outcomes were tracked using kinematic data and conventional clinical assessments...
Source: Singapore Medical Journal - July 1, 2015 Category: Journals (General) Authors: Samuel GS, Choo M, Chan WY, Kok S, Ng YS Tags: Singapore Med J Source Type: research

Improving telestroke treatment times through a quality improvement initiative in a Singapore emergency department.
CONCLUSION: The quality improvement initiative resulted in a reduction in median DTN time. Our approach allowed for a systematic method to resolve delays within the telestroke workflow. This initiative is part of an ongoing effort aimed at providing thrombolysis safely to eligible patients in the shortest possible time. PMID: 30009318 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - July 16, 2018 Category: General Medicine Authors: Mong R, Tiah L, Wong M, Tan C Tags: Singapore Med J Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Impact of Air Pollution and Seasonal Haze on Neurological Conditions.
CONCLUSION: Air pollution is associated with increased risk of certain common neurological disorders. More specific studies are needed to investigate the impact of seasonal haze on neurological conditions in Southeast Asia. PMID: 32200394 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - December 31, 2019 Category: General Medicine Authors: Rocha II, Narasimhalu K, De Silva DA Tags: Ann Acad Med Singapore Source Type: research

Simultaneous cardiocerebral infarctions: a five-year retrospective case series reviewing natural history
CONCLUSION: CCI is a rare but devastating clinical scenario, with high incidence of morbidity and mortality. Treatment strategy can impact patient outcome, and further research is warranted on the ideal acute and post-reperfusion treatments for CCI. In this series, IV tPA at stroke doses appeared to be the preferred initial step for its treatment, with subsequent coronary or cerebral endovascular therapy, if necessary.PMID:33866711 | DOI:10.11622/smedj.2021043
Source: Singapore Medical Journal - April 18, 2021 Category: General Medicine Authors: Cheryl ZY Chong Benjamin YQ Tan Ching-Hui Sia Thet Khaing Leonard LL Yeo Source Type: research

IJERPH, Vol. 18, Pages 4406: Importance of Geospatial Heterogeneity in Chronic Disease Burden for Policy Planning in an Urban Setting Using a Case Study of Singapore
. Dickens Chronic disease burdens continue to rise in highly dense urban environments where clustering of type II diabetes mellitus, acute myocardial infarction, stroke, or any combination of these three conditions is occurring. Many individuals suffering from these conditions will require longer-term care and access to clinics which specialize in managing their illness. With Singapore as a case study, we utilized census data in an agent-modeling approach at an individual level to estimate prevalence in 2020 and found high-risk clusters with >14,000 type II diabetes mellitus cases and 2000–2500 estimated s...
Source: International Journal of Environmental Research and Public Health - April 21, 2021 Category: Environmental Health Authors: Ken Wei Tan Joel R. Koo Jue Tao Lim Alex R. Cook Borame L. Dickens Tags: Article Source Type: research

Effect of Sex on Outcomes of Mechanical Thrombectomy in Basilar Artery Occlusion: A Multicentre Cohort Study
Conclusion: Females achieved comparable functional outcomes compared with males after undergoing MT for BAO acute ischemic stroke.Cerebrovasc Dis
Source: Cerebrovascular Diseases - April 7, 2022 Category: Neurology Source Type: research

Factors Associated with Chronic Kidney Disease and Their Clinical Utility in Primary Care Clinics in a Multi-Ethnic Southeast Asian Population
Conclusions: CKD prevalence in our Southeast Asian population is high and under-documented even in high-risk patients. Our findings highlight factors associated with CKD, and the predictive value of hypertension, diabetes, and advancing age as EHR-based screening targets for CKD. Our results also suggest that complementary educational efforts will be needed to increase physician detection and optimize the management of CKD, especially in high risk and marginalized groups across all clinics in Singapore, and possibly in the region.Nephron
Source: Nephron - December 15, 2017 Category: Urology & Nephrology Source Type: research

Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore
ConclusionsSAPT and DAPT are less effective than warfarin in NVAF patients. DOACs may be considered in view of lower risk of overall bleed.
Source: Clinical Cardiology - November 1, 2017 Category: Cardiology Authors: Xue Ting Wee, Lih Maan Ho, Han Kiat Ho, Joyce Yu ‐Chia Lee, Chun Wei Yap, Henry William, Linus Chong En Chan, Hooi Ching Tay, Cynthia Eei Mei Goh, Doreen Su‐Yin Tan Tags: CLINICAL INVESTIGATIONS Source Type: research

The Translation of Knowledge Into Practice in the Management of Atrial Fibrillation in Singapore
Atrial fibrillation (AF) is a clinically significant cardiac arrhythmia known to increase the risk of stroke by at least four times. Stroke-risk assessment and thromboprophylaxis are vital components in AF management. Guidelines are available to standardise AF management, but physicians ’ adherence to the recommended guidelines has been low.The aims were to:1. Examine and compare the level of knowledge and current practice in AF management between cardiologists and non-cardiologist physicians in Singapore;2.
Source: Heart, Lung and Circulation - March 12, 2018 Category: Cardiology Authors: Fong Yeong Brigitte Woo, Toon Wei Lim, Wai San Wilson Tam Tags: Original Article Source Type: research

The Translation of Knowledge into Practice in the Management of Atrial Fibrillation in Singapore
Atrial fibrillation (AF) is a clinically significant cardiac arrhythmia known to increase the risk of stroke by at least four times. Stroke-risk assessment and thromboprophylaxis are vital components in AF management. Guidelines are available to standardise AF management, but physicians ’ adherence to the recommended guidelines has been low.The aims were to:1. Examine and compare the level of knowledge and current practice in AF management between cardiologists and non-cardiologist physicians in Singapore;2.
Source: Heart, Lung and Circulation - March 12, 2018 Category: Cardiology Authors: Fong Yeong Brigitte Woo, Toon Wei Lim, Wai San Wilson Tam Tags: Original Article Source Type: research

Cross-cultural adaptation and psychometric evaluation of the Singapore version of the Chedoke Arm and Hand Activity.
CONCLUSION: The Singapore version of the CAHAI demonstrated good validity and reliability, similar to the properties of the original CAHAI. Implications for rehabilitation The Singapore version of the Chedoke Arm and Hand Activity Inventory demonstrates evidence of construct validity and inter-rater reliability. The Singapore version of the Chedoke Arm and Hand Activity Inventory can be used by clinicians and researchers to evaluate function in the affected upper extremity for persons with stroke in Singapore. PMID: 29786453 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - May 22, 2018 Category: Rehabilitation Authors: Choo SX, Bosch J, Richardson J, Stratford P, Harris JE Tags: Disabil Rehabil Source Type: research

Interview Functional Independence Measure score: self-reporting as a simpler alternative to multidisciplinary functional assessment.
CONCLUSION: There was no FIM assessment for 14 (29.8%) patients, which highlighted the need for alternative assessment tools. Discrepancies in some scores could be due to ignorance among patients about their own limitations or feelings of embarrassment about reporting. Our results may not be valid for patient populations with cognitive or communication deficits. However, a modest agreement between patient self-reporting and multidisciplinary assessment of FIM motor score was demonstrated. Though patients tend to overrate their performance, self-reported FIM motor score could be an alternative in situations where multidisci...
Source: Singapore Medical Journal - September 5, 2018 Category: General Medicine Authors: Vadassery SJ, Kong KH, Ho WML Tags: Singapore Med J Source Type: research

Reliability and validity of the shortened Singapore versions of the Chedoke Arm and Hand Activity Inventory
Upper limb deficits are common sequelae after a stroke and negatively affect daily living and quality of life. The use of outcome measures to evaluate upper limb function is essential to assess sensorimotor recovery and to determine the effectiveness of rehabilitation. The aim of this study was to estimate the construct validity and inter-rater reliability of three shortened versions of the Singapore version of the Chedoke Arm and Hand Activity Inventory (CAHAI-SG) comprising seven, eight, and nine test items. The sample consisted of 55 inpatients with acute/subacute stroke to whom the CAHAI-SG, Fugl-Meyer Assessment of Up...
Source: International Journal of Rehabilitation Research - November 10, 2018 Category: Rehabilitation Tags: Original articles Source Type: research