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Sleep apnoea greatly increases risk of stroke, US scientists find
Stanford study shows that people with the common sleep disorder are also five times more likely to develop atrial fibrillationSnoring loudly and feeling tired even after a full night ’s sleep could leave people at an increased risk of a stroke, a study has shown.Hundreds of millions of people globally have sleep apnoea, a disorder with symptoms including stopping and starting breathing, making snorting noises, waking up a lot and loud snoring. Many have the condition but are undiagnosed.Continue reading...
Source: Guardian Unlimited Science - August 25, 2023 Category: Science Authors: Andrew Gregory Health editor in Amsterdam Tags: Stroke Sleep apnoea Medical research Heart disease Science Society Source Type: news

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Longer sleep linked to stroke
Conclusion This cohort study found that, overall, people who sleep for more than eight hours have a 46% increased risk of stroke. When analysed separately, there was no statistically significant association for men, but a much higher increased risk for women, of 80%. A major strength of the study is the number of potential confounding factors that the researchers tried to account for, including many cardiovascular risk factors. However, it did not account for other illnesses such as sleep apnoea or cancer, which may have had an effect on the amount of sleep and risk of stroke. In addition, the study is reliant on the i...
Source: NHS News Feed - February 26, 2015 Category: Consumer Health News Tags: Lifestyle/exercise Neurology Older people Source Type: news

How People With Diabetes Can Lower Stroke Risk
After spending nearly two decades trying to manage her Type 2 diabetes, Agnes Czuchlewski landed in the emergency room in 2015, with news that she’d just experienced a heart attack. She also learned that she had metabolic syndrome, a cluster of conditions that includes diabetes but also brings higher risk of heart disease and stroke. “Because I needed to lose quite a bit of weight when I was first diagnosed, I was focused on the number I saw on the scale, and then on my blood-sugar numbers,” recalls Czuchlewski, 68, who lives in New York City. “I didn’t realize other numbers came into play, li...
Source: TIME: Health - November 10, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized Disease healthscienceclimate Source Type: news

Sleep Duration and the Risk of Mortality From Stroke in Japan: The Takayama Cohort Study.
CONCLUSIONS: Data suggest that longer sleep duration is associated with increased mortality from total and ischemic stroke. Short sleep duration may be associated with a decreased risk of mortality from hemorrhagic stroke in men. PMID: 26521720 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - November 4, 2015 Category: Epidemiology Tags: J Epidemiol Source Type: research

Clinical course and risk factors for sleep disturbance in patients with ischemic stroke
ConclusionThe prevalence rates of sleep disturbance before and during the acute and chronic stroke periods were 34.3%, 37.4%, and 29.7%, respectively. The incidence of stroke-related insomnia was 15.6%. Patients with insomnia before stroke may recover after the stroke. Atrial fibrillation, hypertension, and mood disturbance were associated with a higher risk of sleep disturbance in the acute stroke period, whereas low education and mood disturbance were associated with insomnia in the chronic stroke period.
Source: PLoS One - November 8, 2022 Category: Biomedical Science Authors: Hui-Ju Tsai Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (I9-4B)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (S53.005)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Sleep Source Type: research

New Imaging-based definition of Stroke Boosts Annual Incidence of Recurrent Ischemic Stroke in the United States by 80percnt (P1.091)
CONCLUSIONS: Adopting a more expansive definition of stroke that incorporates presence of SBI would boost current estimates of the annual incidence of recurrent ischemic stroke in the US by approximately 80[percnt].Disclosure: Dr. Lin has nothing to disclose. Dr. Ovbiagele has nothing to disclose. Dr. Chui has received personal compensation in an editorial capacity for Archives of Neurology, Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Ovbiagele, B., Chui, H., Towfighi, A. Tags: Neuroepidemiology: Cerebrovascular Disease, Critical Care, Epilepsy, Child Neurology, and Sleep Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

The estimation of excessive daytime sleepiness in post-stroke patients - the polysomnographic study
Publication date: Available online 25 May 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): Helena Martynowicz, Anna Jodkowska, Robert Skomro, Paweł Gać, Agnieszka Brylka, Maciej Bladowski, Anna Wojakowska, Grzegorz Mazur, Rafał PorębaAbstractExcessive daytime sleepiness (EDS) has been reported in stroke patients. EDS in acute stroke was studied repeatedly, but there is a modest amount of data in post-stroke patients. The aim of this study was to assess the frequency of EDS and characterize sleep architecture in patients>3 months after stroke and identify factors which may affect EDS.66 patients were enrolled...
Source: Respiratory Physiology and Neurobiology - May 26, 2019 Category: Respiratory Medicine Source Type: research

The estimation of excessive daytime sleepiness in post-stroke patients - a polysomnographic study
Publication date: September 2019Source: Respiratory Physiology & Neurobiology, Volume 267Author(s): Helena Martynowicz, Anna Jodkowska, Robert Skomro, Paweł Gać, Agnieszka Brylka, Maciej Bladowski, Anna Wojakowska, Grzegorz Mazur, Rafał PorębaAbstractExcessive daytime sleepiness (EDS) has been reported in stroke patients. EDS in acute stroke was studied repeatedly, but there is a modest amount of data in post-stroke patients. The aim of this study was to assess the frequency of EDS and characterize sleep architecture in patients>3 months after stroke and identify factors which may affect EDS.66 patients were enrolled, ...
Source: Respiratory Physiology and Neurobiology - June 2, 2019 Category: Respiratory Medicine Source Type: research

Influences of Daily Life Habits on Risk Factors of Stroke Based on Decision Tree and Correlation Matrix.
Conclusions: Establishment of a model for stroke risk assessment, analysis of factors influencing risk factors of stroke, analysis of relationships among those factors, and derivation of knowledge-based rules are helpful for prevention and treatment of stroke. PMID: 32565878 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - June 24, 2020 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Brainstem strokes are associated with increased obstructive apnea index during sleep acutely after stroke
Sleep-disordered breathing (SDB) and ischemic stroke are intertwined pathologies. Stroke topography may influence SDB presentation. We investigated the association of stroke topography with obstructive (OAI) and central apnea indices (CAI) in acute and subacute stroke.The prospective multicentre SAS-CARE study included 204 stroke patients. Demographic, anthropometric and stroke characteristics were recorded at admission. Stroke topography (left- and right-sided, supra- and infratentorial, cortical, subcortical, insular, brainstem, cerebellar) was visually scored on the MRI at admission and binary coded. Polysomnography was...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Filchenko, I., Dekkers, M., Baillieul, S., Seiler, A., Schmidt, M., Bernasconi, C., Bassetti, C. Tags: Sleep and control of breathing Source Type: research