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Total 228 results found since Jan 2013.

Predictors of Thrombolysis Administration in Mild Stroke Clinical Sciences
Conclusions—Mild acutely presenting stroke patients are more likely to receive thrombolysis if they are young, white, or Hispanic and arrive early to the hospital with more severe neurological presentation. Identification of predictors of thrombolysis is important in design of future studies to assess the use of thrombolysis for mild stroke.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Negar Asdaghi, Kefeng Wang, Maria A. Ciliberti-Vargas, Carolina Marinovic Gutierrez, Sebastian Koch, Hannah Gardener, Chuanhui Dong, David Z. Rose, Enid J. Garcia, W. Scott Burgin, Juan Carlos Zevallos, Tatjana Rundek, Ralph L. Sacco, Jose G. Romano Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Correlation of NIH Stroke Scale Change and Vascular Risk Factors in Acute Stroke Patients (P7.164)
Conclusion:In this small sample, change in NIH stroke scale admission through discharge may be a useful quality outcome measure in acute stroke. Tobacco use was harmful in this sample. Presence of hypertension and absence of diabetes showed benefit in select acute stroke outcomes. Investigating the special cause improvements in this population may help identify ways to improve outcomes. Shewhart control charts may provide useful information when examining quality that might be missed on routine statistical methods.Disclosure: Dr. Krishnamohan has nothing to disclose. Dr. Dobbs has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Krishnamohan, P., Dobbs, M. Tags: Cerebrovascular Disease and Interventional Neurology: Post-Stroke Function Source Type: research

Transition of European Cooperative Acute Stroke Study III Results to Clinical Practice: Ninety-Day Outcomes in a US Cohort Brief Reports
Conclusions— For patients treated with intravenous tissue-type plasminogen activator 3 to 4.5 hours from onset in everyday practice in the United States, there is no evidence for increased risk or worse outcomes compared with standard treatment ≤3 hours.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Cronin, C. A., Langenberg, P., Dutta, T. M., Kittner, S. J. Tags: Brief Reports Source Type: research

Factors associated with delay in presentation to the hospital for young adults with ischemic stroke (P3.237)
Conclusions: A majority of young adults with ischemic stroke presented outside the time window for intravenous fibrinolysis. Diabetes, single status, and unemployed status were associated with delayed presentation. Disclosure: Dr. Leung has nothing to disclose. Dr. Louis R. Caplan has received personal compensation in an editorial capacity for JAMA Neurology.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Leung, L., Caplan, L. Tags: Stroke in the Young Source Type: research

Venous Thromboembolism in the Get With The Guidelines-Stroke Acute Ischemic Stroke Population: Incidence and Patterns of Prophylaxis
Conclusions: Despite a high overall rate of VTE prophylaxis, VTE was found to occur in approximately 3% of GWTG-S patients. Reported rates of VTE prophylaxis differed among hospitals by region and hospital type, and among patients by age, race, and medical comorbidities.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: G. Logan Douds, Anne S. Hellkamp, DaiWai M. Olson, Gregg C. Fonarow, Eric E. Smith, Lee H. Schwamm, Kevin M. Cockroft Tags: Original Articles Source Type: research

Elevated thyroid autoantibodies and intracranial stenosis in stroke at an early age
ConclusionsThyroid autoantibodies may be associated with the presence of intracranial large artery stenosis in young stroke patients, potentially providing insight on immune pathogenesis of intracranial large artery stenosis.
Source: International Journal of Stroke - September 12, 2013 Category: Neurology Authors: Zhenghao Shi, Xuting Zhang, Zhicai Chen, David S Liebeskind, Min Lou Tags: Research Source Type: research

Primary Stroke Prevention in Women (S4.006)
Conclusions: Our pilot data suggest that OB/GYN, IM and FM have moderate awareness of PCP guidelines, correctly answering approximately 2/3 of questions. Educational gaps and barriers were identified in all groups. We recommend increasing awareness about PSP in women among PCPs.Disclosure: Dr. Patel has nothing to disclose. Dr. Tark has nothing to disclose. Dr. Berekashvili has nothing to disclose. Dr. Steinberg has nothing to disclose. Dr. Balucani has nothing to disclose. Dr. Weedon has nothing to disclose. Dr. Akivis has nothing to disclose. Dr. Sadovsky has nothing to disclose. Dr. Adeishvili has nothing to disclose. D...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Patel, P., Tark, B., Berekashvili, K., Steinberg, L., Balucani, C., Weedon, J., Akivis, A., Sadovsky, R., Adeishvili, G., Gabbur, N., Adler, Z., Chekuru, L., Abulafia, O., Weiss, S., Levine, S. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Frequency of Hemorrhage on Follow Up Imaging in Stroke Patients Treated With rt-PA Depending on Clinical Course
Conclusions: Frequency of hemorrhagic transformation in Routine follow-up brain imaging and consecutive changes in therapeutic management were different depending on clinical course measured by NHISS score. Introduction Brain imaging 24–36 h after systemic thrombolysis for acute ischemic stroke is recommended in American Stroke Association and European Stroke Organization guidelines (1, 2). Brain imaging is performed to detect secondary bleeding or hemorrhagic transformation in order to adapt medical stroke prevention if necessary. Guideline recommendations are based on the results of the first study on rt-PA...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Conveniently-Grasped Field Assessment Stroke Triage (CG-FAST): A Modified Scale to Detect Large Vessel Occlusion Stroke
Conclusions: CG-FAST scale could be an effective and simple scale for accurate identification of LVOS among AIS patients. Introduction Large vessel occlusion stroke (LVOS) often leads to severe disability and mortality. Although endovascular therapy (EVT) has been proved to be effective for LVOS patients (1–9), especially in anterior circulation, its benefit is highly time-dependent (10, 11). As hospitals with around-the-clock endovascular capability are scarce in many parts of the world and patients admitted directly to a CSC would have better outcomes than those receiving drip and ship treatment (12, 13), t...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research