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Total 228 results found since Jan 2013.

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis
Conclusions: Our results show worldwide efficacy of BM-MSCs in improving functional outcomes in pre-clinical animal models of stroke and support testing these cells in clinical trials in various ranges of time windows using different delivery routes. The continued growing number of publications showing functional benefit of BM-MSCs are now adding limited value to an oversaturated literature spanning 18 years. Researchers should focus on identifying definitive mechanisms on how BM-MSCs lead to benefit in stroke models. Introduction Ischemic stroke is the 5th leading cause of death and the leading cause of long term di...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection
Conclusion: The present study suggests that lesion patterns observed from DWI of patients with PFO and SIAD might provide clues to the etiology of infarcts. Single lesions (cortical or subcortical) might be a typical feature of PFO associated strokes, while multiple lesions in one vascular territory might be a specific feature of SIAD associated strokes. Introduction Both patent foramen ovale (PFO) and spontaneous intracranial artery dissection (SIAD) are important stroke risk factors, especially in young and middle-aged adults (1–3). About 25% of patients with ischemic stroke are cryptogenic (4), and PFO is ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Memory gaps in graduates a 'stroke warning sign'
Conclusion This study showed that highly educated people who notice memory complaints in themselves may be more likely to develop stroke than those who don’t, over an average of 12 years. The study had a number of strengths, such as its population-based prospective design and availability of data on more than 9,000 participants at baseline with a long follow-up. However, there were also a number of limitations that weaken the strength of the conclusions. It was not clear whether the memory complaints were assessed just once at the start of the study or an ongoing basis. Some people may report memory complaints that are o...
Source: NHS News Feed - December 12, 2014 Category: Consumer Health News Tags: Neurology Mental health Older people Source Type: news

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Stroke Severity in Men and Women: What Proportion of the Disparity Can Be Explained by Differences in Cardiovascular Risk Factors? (S12.005)
Conclusion: In our biracial sample, women presented with more severe strokes than men. This difference remained significant even after adjustment for age, stroke subtype, and cardiovascular risk factors. Further, over 1/3 of the observed gender difference in stroke severity was unexplained.. Additional study is warranted to investigate the etiology of the gender differences in stroke severity.Disclosure: Dr. Albright has received research support from The Agency for Healthcare Research and Quality, and the National Institute on Minority Health and Health Disparities. Dr. Boehme has nothing to disclose. Dr. Sen has nothing ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Albright, K., Boehme, A., Sen, B., Mullen, M., Gonzales, N., Savitz, S., Martin-Schild, S. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology and Risk Factors Source Type: research

Medical therapy does not confer stroke prevention for all patients; identification of high-risk patients with asymptomatic carotid stenosis is still needed.
CONCLUSIONS: Prophylactic CR + BMT does not provide overall late stroke prevention compared with BMT alone. Diabetics with a history of stroke, in particular, are at an increased risk of stroke despite BMT. Timely CR + BMT for high-risk patients is still indicated. PMID: 31345008 [PubMed - as supplied by publisher]
Source: International Angiology - July 28, 2019 Category: Cardiology Tags: Int Angiol Source Type: research

Mediterranean diet cuts heart and stroke risk
Conclusion The results of this randomised controlled trial appear to confirm previous studies that there are benefits to following a Mediterranean diet. The trial has many strengths, including its large size, long period of follow-up, thorough assessment of medical outcomes (including reviewing medical records and having contact with the family doctor), and careful attempts to assess whether the diets were being followed. As this is a randomised controlled trial, it should also balance out other health and lifestyle differences between the groups that may influence cardiovascular risk. This avoids the limitations of m...
Source: NHS News Feed - February 26, 2013 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

HINTS Outperforms ABCD2 to Screen for Stroke in Acute Continuous Vertigo and Dizziness.
CONCLUSIONS: HINTS substantially outperforms ABCD2 for stroke diagnosis in ED patients with AVS. It also outperforms MRI obtained within the first 2 days after symptom onset. While HINTS testing has traditionally been performed by specialists, methods for empowering emergency physicians (EPs) to leverage this approach for stroke screening in dizziness should be investigated. PMID: 24127701 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - October 1, 2013 Category: Emergency Medicine Authors: Newman-Toker DE, Kerber KA, Hsieh YH, Pula JH, Omron R, Saber Tehrani AS, Mantokoudis G, Hanley DF, Zee DS, Kattah JC Tags: Acad Emerg Med Source Type: research

Trends in one-year mortality for stroke in a tertiary academic center in Saudi Arabia: a 5-year retrospective analysis
CONCLUSION: We observed no decline in stroke mortality in our center over the 5-year span. The establishment of stroke systems of care, use of thrombolytic agents, and opening of a stroke unit should play an important role in a decline in stroke mortality.  LIMITATIONS: Retrospective single center study. Mortality data were available only for patients who died in our hospital.   
Source: Annals of Saudi Medicine - May 29, 2016 Category: Journals (General) Tags: ISSUE 3 Source Type: research

HINTS Outperforms ABCD2 to Screen for Stroke in Acute Continuous Vertigo and DizzinessEl HINTS Supera el ABCD2 en el Despistaje del Ictus en los Pacientes con Vértigo y Mareo Agudos Persistentes
ConclusionsHINTS substantially outperforms ABCD2 for stroke diagnosis in ED patients with AVS. It also outperforms MRI obtained within the first 2 days after symptom onset. While HINTS testing has traditionally been performed by specialists, methods for empowering emergency physicians (EPs) to leverage this approach for stroke screening in dizziness should be investigated. Resumen ObjetivosEl mareo y el vértigo contabilizan aproximadamente 4 millones de visitas anuales a los servicios de urgencias (SU) en Estados Unidos, y de 160.000 a 240.000 (4% al 6%) tienen un origen cerebrovascular. El diagnóstico de ictus en los ...
Source: Academic Emergency Medicine - October 15, 2013 Category: Emergency Medicine Authors: David E. Newman‐Toker, Kevin A. Kerber, Yu‐Hsiang Hsieh, John H. Pula, Rodney Omron, Ali S. Saber Tehrani, Georgios Mantokoudis, Daniel F. Hanley, David S. Zee, Jorge C. Kattah Tags: Original Research Contribution Source Type: research

Stroke And Cerebrovascular Risk Factors Knowledge In Patients Admitted To A Cardiovascular Ward. (P1.135)
Conclusion: Even in these selected population, with previous or current CVD, a large amount of RF and a high rate of previous medical consultations, knowledge about stroke showed to be very low indicating a poor quality of preventive measures and the need to emphasize educational interventions.Disclosure: Dr. Muñoz has nothing to disclose. Dr. Gonzalez Toledo has nothing to disclose. Dr. Pagani Cassara has nothing to disclose. Dr. Tamargo has nothing to disclose. Dr. Thomson has nothing to disclose. Dr. Nadile has nothing to disclose. Dr. Ferre has nothing to disclose. Dr. Klein has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Munoz Giacomelli, F., Gonzalez Toledo, M., Pagani Cassara, F., Tamargo, A., Thomson, A., Nadile, D., Ferre, A., Klein, F. Tags: Cerebrovascular Disease and Interventional Neurology: Atrial Fibrillation and Miscellaneous Source Type: research

Perioperative stroke in patients undergoing elective spinal surgery: a retrospective analysis using the Japanese diagnosis procedure combination database
Conclusions: Perioperative stroke occurred in 0.22 % of patients undergoing spinal surgery. Resection of a spinal cord tumor was associated with increased risk of perioperative stroke as well as advanced age, comorbidities at admission, cervical spine surgery, surgery in a teaching hospital, and length of stay.
Source: BMC Musculoskeletal Disorders - October 2, 2015 Category: Orthopaedics Authors: Junichi OhyaHirotaka ChikudaTakeshi OichiHiromasa HoriguchiKatsushi TakeshitaSakae TanakaHideo Yasunaga Source Type: research

Findings from the University of Minnesota Posterior Circulation Stroke Database (P3.262)
Conclusions:Our work adds to the meager literature on AIPCS. Further studies of medical and endovascular intervention in AIPCS secondary to LAA are particularly needed in order to define optimal treatment in this patient subset.Disclosure: Dr. Bell has nothing to disclose. Dr. Anderson has received personal compensation in an editorial capacity Neurology: Clinical Practice and Continuum Audio. Dr. Lakshminarayan has nothing to disclose. Dr. Jagadeesan has nothing to disclose. Dr. Reshi has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Ezzeddine has received personal compensation for activities with Air Liqui...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bell, C., Anderson, D., Lakshminarayan, K., Jagadeesan, B., Reshi, R. A., Miller, B., Ezzeddine, M., Streib, C. Tags: Cerebrovascular Disease Epidemiology Source Type: research