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Understanding Coordinator Roles in Acute Stroke Care: A National Survey
Globally, stroke is a major contributor to death and disability.1 Evidence-based care in hospital after an acute stroke ensures improved survival and reduced disability, but care quality can vary.2,3 Clinical coordinators have an essential role in improving best-practice in trauma, cancer, diabetes, and heart failure conditions.4-7 Within stroke, coordinator roles are not new; in 1970, a study outlining the ‘Stroke Team’ model was published, which included a physician, nurse-coordinator and physical therapist.
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2021 Category: Neurology Authors: Tara Purvis, Sandy Middleton, Anne W. Alexandrov, Monique F. Kilkenny, Skye Coote, Sarah Kuhle, Dominique A. Cadilhac Source Type: research

Risk Factors for Poor Outcome and Mortality at 3 Months after the Ischemic Stroke in Patients with Atrial Fibrillation
Conclusions: Age, gender, and NIHSS score were independently associated with poor outcome for IS or TIA patients with nonvalvular atrial fibrillation in the early recovery stage.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2013 Category: Neurology Authors: Shuya Li, Xingquan Zhao, Chunxue Wang, Liping Liu, Gaifen Liu, Yilong Wang, Chunjuan Wang, Jing Jing, Yong-Jun Wang Tags: Original Articles Source Type: research

Ischemic Stroke Risk After Acute Coronary Syndrome Stroke
Conclusions Non-STEMI and STEMI confer an equally increased risk of IS. Studies exploring IS mechanisms in cardiac patients are needed to improve and tailor stroke prevention strategies.
Source: JAHA:Journal of the American Heart Association - July 12, 2016 Category: Cardiology Authors: Yaghi, S., Pilot, M., Song, C., Blum, C. A., Yakhkind, A., Silver, B., Furie, K. L., Elkind, M. S. V., Sherzai, D., Sherzai, A. Z. Tags: Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Source Type: research

Cerebral hemorrhage following thrombolytic therapy for stroke: Are neutrophils really neutral?
An ideal biomarker can accurately predict disease risk stratification. The longstanding link between inflammatory responses and atherosclerotic disease and vascular events suggests great promise for inflammatory measures as biomarkers in stroke and other vascular disease. Recent studies across multiple areas and disciplines have suggested that leukocytes, as an inflammatory marker, and specifically neutrophils, may hold promise in predicting poor outcomes in various cardiovascular diseases (e.g., heart failure, acute coronary syndromes, stable coronary artery disease), including stroke, as well as in neoplasms, infections,...
Source: Neurology - October 19, 2015 Category: Neurology Authors: Roever, L., Levine, S. R. Tags: All Cerebrovascular disease/Stroke, All epidemiology, Prevalence studies, Risk factors in epidemiology, Intracerebral hemorrhage EDITORIALS Source Type: research

Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF
Conclusion: Increasing age and a prolonged PR interval at enrollment were independently associated with an increased AF incidence in CS patients. However, they offered only moderate predictive ability in determining which CS patients had AF detected by the ICM.
Source: Neurology - January 18, 2016 Category: Neurology Authors: Thijs, V. N., Brachmann, J., Morillo, C. A., Passman, R. S., Sanna, T., Bernstein, R. A., Diener, H.-C., Di Lazzaro, V., Rymer, M. M., Hogge, L., Rogers, T. B., Ziegler, P. D., Assar, M. D. Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Risk factors in epidemiology ARTICLE Source Type: research

Ischemic Stroke Risk After Acute Coronary Syndrome Stroke
BackgroundPrior studies show an increased risk of ischemic stroke (IS) after myocardial infarction; however, there is limited evidence on long‐term risk and whether it is directly related to cardiac injury. We hypothesized that the risk of IS after acute coronary syndrome is significantly higher if there is evidence of cardiac injury, such as ST‐segment elevation myocardial infarction (STEMI) or non‐STEMI, than when there is no evidence of cardiac injury, such as in unstable angina.Methods and ResultsAdministrative claims data were obtained from all emergency department encounters and hospitalizations at California's...
Source: JAHA:Journal of the American Heart Association - July 12, 2016 Category: Cardiology Authors: Yaghi, S., Pilot, M., Song, C., Blum, C. A., Yakhkind, A., Silver, B., Furie, K. L., Elkind, M. S. V., Sherzai, D., Sherzai, A. Z. Tags: Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Original Research Source Type: research

Cerebral Hemodynamic Effects of Cheyne –Stokes Respiration in a Patient with Stroke
Cheyne –Stokes respiration (CSR) and central sleep apnea (CSA) are common in patients with heart failure and/or stroke. We aim to describe the cerebrovascular effects of CSR during the acute phase of stroke in a heart failure patient.
Source: Journal of Stroke and Cerebrovascular Diseases - March 14, 2017 Category: Neurology Authors: R.C. Nogueira, R.B. Panerai, M.J. Teixeira, T.G. Robinson, E. Bor-Seng-Shu Tags: Case Studies Source Type: research

Right Heart Failure as a Risk for Stroke in Patients with Chronic Obstructive Pulmonary Disease: A Case-Control Study
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition characterized by complex lesions of the lungs and other organs as well as a progressive obstruction of the airway. In COPD patients, heart failure (HF) is associated with worse conditions such as inflammation, arterial stiffness, and increased risk mortality. However, the association of HF, COPD, and stroke are unclear; the examination of the role of HF, especially right HF, about increased risk of stroke in COPD patients has not been studied.
Source: Journal of Stroke and Cerebrovascular Diseases - August 22, 2017 Category: Neurology Authors: Arturo Orea-Tejeda, Katya Bozada-Guti érrez, Juan Pineda-Juárez, Dulce González-Islas, Brenda Santellano-Juárez, Candace Keirns-Davies, Viridiana Peláez-Hernández, Rafael Hernández-Zenteno, Rocio Sánchez-Santillán, Carlos Cintora-Martínez Source Type: research

Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke Original Articles
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research

Duration of Diabetes Mellitus and Risk of Thromboembolism and Bleeding in Atrial Fibrillation: Nationwide Cohort Study Clinical Sciences
Conclusions— In patients with atrial fibrillation, longer duration of diabetes mellitus was associated with a higher risk of thromboembolism, but not with a higher risk of anticoagulant-related bleeding. Considering the critical balance between preventing thromboembolism and avoiding bleeding, longer duration of diabetes mellitus may favor initiation of anticoagulant therapy.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Overvad, T. F., Skjoth, F., Lip, G. Y. H., Lane, D. A., Albertsen, I. E., Rasmussen, L. H., Larsen, T. B. Tags: Thrombosis risk factors, Type 1 diabetes, Type 2 diabetes, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Age and gender differences in acute stroke hospital patients.
In conclusion, considerable differences were established between age and gender stroke patient groups, confirming the need of permanent national stroke registry and subsequent targeted action in secondary care, and prevention with education on risk factors, preferably personally tailored. PMID: 27333721 [PubMed - in process]
Source: Acta Clinica Croatica - June 24, 2016 Category: Journals (General) Tags: Acta Clin Croat Source Type: research

Multiple risk factors and ischaemic stroke in the elderly Asian population with and without atrial fibrillation. An analysis of 425,600 Chinese individuals without prior stroke.
In conclusion, an increasing cluster of multiple cardiovascular risk factors (besides AF) contributes to a greater risk for ischaemic stroke, especially in the elderly population. If elderly and with multiple risk factors, non-AF patients may have a risk of incident ischaemic stroke that is comparable or even higher than patients with AF, suggesting that the incremental stroke risk attributable to AF is marginal in such 'high risk' patients. PMID: 26322338 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 31, 2015 Category: Hematology Authors: Guo Y, Wang H, Tian Y, Wang Y, Lip GY Tags: Thromb Haemost Source Type: research

Japanese and Non-Japanese Patients with Transient Ischemic Attack or Minor Stroke: A Five-Year Risk Analysis of Stroke and Vascular Events.
CONCLUSIONS: Recurrent stroke and intracranial hemorrhage were determined to be more prevalent at 5 years after TIA or minor stroke in Japanese patients than in non-Japanese patients. Strategies to mitigate the long-term risks of stroke, aside from adherence to current guidelines, should take Japanese-patient-specific residual risks into account. PMID: 32938836 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - September 19, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Riga East University Hospital Stroke Registry-An Analysis of 4915 Consecutive Patients with Acute Stroke
Conclusions: Our stroke registry data are comparable to those of other major registries. Analysis of stroke registry data is important for improving stroke care and obtaining additional information for stroke studies.PMID:34207100 | DOI:10.3390/medicina57060632
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Guntis Karelis Madara Micule Evija Klavina Iveta Haritoncenko Ilga Kikule Biruta Tilgale Inese Polaka Source Type: research