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NCI study finds extreme obesity may shorten life expectancy up to 14 years
(NIH/National Cancer Institute) Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries.
Source: EurekAlert! - Medicine and Health - July 8, 2014 Category: Global & Universal Source Type: news

Obesity Can Shorten Life Expectancy by 14 Years
Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries.
Source: Disabled World - July 10, 2014 Category: Disability Tags: Childhood Obesity Source Type: news

With advances in HIV care, survivors face other disease risks
As effective treatments for HIV become more widely available in low- and middle-income countries, there's an urgent need to assess and manage health risks in the growing number of people living with HIV. "Today, with over 35 million people living (and aging) with HIV and over two million becoming infected every year, we are faced with a new challenge: addressing morbidity and mortality -- heart disease, stroke, diabetes and metabolic complications, renal disease, cancers, liver disease, and mental illness," authors write.
Source: ScienceDaily Headlines - August 13, 2014 Category: Science Source Type: news

Watch less TV to prevent obesity, says NICE
“Take TV-free days to combat obesity, health experts urge,” The Guardian reports. This is one of a range of new recommendations from National Institute of Health and Care Excellence (NICE) draft guidelines that are designed to help adults and children maintain a healthy weight.Although the headlines have largely focused on TV (as well as other types of screen time, such as smartphones), the recommendations cover a range of health-related behaviours, such as walking to work and avoiding fizzy drinks.This draft guidance is mainly aimed at people in organisations who set up, pay for, or put into practice programmes that ...
Source: NHS News Feed - September 23, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Food/diet Obesity Source Type: news

High early cardiovascular mortality after liver transplantation
In conclusion, we provide the first multicenter prognostic model for the prediction of early post‐LT CVD death, the most common cause of early post‐LT mortality in the current transplant era. However, evaluations of additional CVD‐related variables not collected by the OPTN are needed in order to improve the model's accuracy and potential clinical utility. Liver Transpl, 2014. © 2014 AASLD.
Source: Liver Transplantation - October 24, 2014 Category: Transplant Surgery Authors: Lisa B. VanWagner, Brittany Lapin, Josh Levitsky, John T. Wilkins, Michael M. Abecassis, Anton I. Skaro, Donald M. Lloyd‐Jones Tags: Original Article Source Type: research

Acute presentations of inherited metabolic disorders: investigation and initial management
Inborn errors of metabolism are individually rare but so many have now been described that the general paediatrician will encounter one from time to time. For many, early treatment is important. Unfortunately most that present acutely do so with non-specific symptoms and signs. It is therefore necessary to identify and investigate those at high risk. The most common problems are neurological (including coma, seizures and stroke-like episodes), hypoglycaemia, disorders of acid-base regulation, acute liver disease, rhabdomyolysis, cardiomyopathy and sudden collapse.
Source: Paediatrics and Child Health - November 4, 2014 Category: Pediatrics Authors: A.A.M. Morris, J.V. Leonard Tags: Symposium: inborn errors of metabolism Source Type: research

The hepatic transcriptome of young suckling and aging intrauterine growth restricted male rats
Intrauterine growth restriction leads to the development of adult onset obesity/metabolic syndrome, diabetes mellitus, cardiovascular disease, hypertension, stroke, dyslipidemia, and non‐alcoholic fatty liver disease/steatohepatitis. Continued postnatal growth restriction has been shown to ameliorate many of these sequelae. To further our understanding of the mechanism of how intrauterine and early postnatal growth affects adult health we have employed Affymetrix microarray‐based expression profiling to characterize hepatic gene expression of male offspring in a rat model of maternal nutrient restriction in early and l...
Source: Journal of Cellular Biochemistry - November 7, 2014 Category: Biochemistry Authors: William A. Freije, Shanthie Thamotharan, Regina Lee, Bo‐Chul Shin, Sherin U. Devaskar Tags: Article Source Type: research

Ten-point plan to tackle liver disease published
"Doctors call for tougher laws on alcohol abuse to tackle liver disease crisis," The Guardian reports. But this is just one of 10 recommendations for tackling the burden of liver disease published in a special report in The Lancet.The report paints a grim picture of an emerging crisis in liver disease in the UK, saying it is one of the few countries in Europe where liver disease and deaths have actually increased rapidly over the last 30 years. It concludes with 10 recommendations to tackle the burden of liver disease.The media has approached the recommendations from many different angles, with many sources only ...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise QA articles Source Type: news

Offer weight loss surgery to obese people with diabetes
A quarter of the UK population is now obese, fuelling a rise in cases of type 2 diabetes, as well as heart disease, fatty liver disease and cancer. One in 20 people in the UK has type 2 diabetes, a progressive disease that causes heart disease, stroke, blindness, kidney failure and limb amputations. Updated NICE guidance focuses on identifying, assessing and treating people who are already obese.
Source: NHS Networks - December 1, 2014 Category: UK Health Authors: Maria Axford Source Type: news

Erectile dysfunction and obstructive sleep apnea: From mechanisms to a distinct phenotype and combined therapeutic strategies
Non-communicable Diseases (NCDs), mainly cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases, are responsible for two-thirds of the 57 million annual deaths worldwide. Tobacco smoking, physical inactivity, unhealthy diets and the resulting obesity are established risk factors for many chronic diseases (Figure 1). Management of the rise in the prevalence of chronic diseases is a major challenge facing governments and health-care systems worldwide. As these disorders are now the leading causes of death and hospitalizations, health authorities assign high priority to heart disease, diabetes, sleep apne...
Source: Sleep Medicine Reviews - December 27, 2014 Category: Sleep Medicine Authors: Jean-Louis Pépin, Renaud Tamisier, Diane Godin-Ribuot, Patrick Lévy Tags: Guest editorial Source Type: research

The Surprising Connection Between Problem Drinking And Working Too Much
If you're always working late, your job could be taking a toll on your health in more ways than you may realize, new research suggests. Publishing in the British Medical Journal Tuesday, a systematic review and meta-analysis explored the potential link between the number of hours a person works and their alcohol consumption arrived at a startling conclusion: people who work more than 48 hours each week are 13 percent more likely to drink a risky amount of alcohol than those who work 35 to 40 hours each week. The analysis, which was completed by a team of researchers in Finland, included 81 studies representing more than...
Source: Healthy Living - The Huffington Post - January 15, 2015 Category: Consumer Health News Source Type: news

FloTrac® Monitoring System: What Are Its Uses in Critically Ill Medical Patients?
Abstract : The FloTrac®/Vigileo device uses arterial pressure waveform analysis to calculate stroke volume and cardiac output; it does not require calibration against an independent measurement of cardiac output. Consequently, it provides a method to determine hemodynamic status, changes in the clinical course and responses to therapeutic interventions in patients who have arterial catheters in place. These devices perform relatively well in stable patients undergoing surgery and having an acceptable percentage error in differences between the FloTrac® device and invasive monitoring using pulmonary catheters. Ho...
Source: The American Journal of the Medical Sciences - January 12, 2015 Category: Journals (General) Authors: Argueta E, Berdine G, Pena C, Nugent KM Tags: Am J Med Sci Source Type: research

Does moderate boozing reduce heart failure risk?
Conclusion This study suggests drinking up to about 12 UK units a week is associated with a lower risk of heart failure in men compared with never drinking alcohol. There was a similar result for women, but the results were not as robust and did not rule out the possibility of there being no difference. The study benefits from its large size (more than 14,000 people) and the fact it collected its data prospectively over a long period of time. However, studying the impact of alcohol on outcomes is fraught with difficulty. These difficulties include people not being entirely sure what a "drink" or a "unit&q...
Source: NHS News Feed - January 21, 2015 Category: Consumer Health News Tags: Heart/lungs Food/diet Source Type: news

Does moderate drinking reduce heart failure risk?
Conclusion This study suggests drinking up to about 12 UK units a week is associated with a lower risk of heart failure in men compared with never drinking alcohol. There was a similar result for women, but the results were not as robust and did not rule out the possibility of there being no difference. The study benefits from its large size (more than 14,000 people) and the fact it collected its data prospectively over a long period of time. However, studying the impact of alcohol on outcomes is fraught with difficulty. These difficulties include people not being entirely sure what a "drink" or a "unit&q...
Source: NHS News Feed - January 20, 2015 Category: Consumer Health News Tags: Heart/lungs Food/diet Source Type: news

Flu and freezing weather may be driving up winter death rates
Conclusion There are always more deaths in winter than other seasons, particularly among elderly people. But why these fairly dramatic spikes in the death rate have occurred is still not understood. It should be noted these figures are provisional, as there can be a delay in the ONS receiving the data. Although the media has focused on the likely cause being flu, the numbers provided are for all respiratory conditions. Cold weather can exacerbate many of these conditions, such as asthma and chronic obstructive pulmonary disease. For most fit and healthy people, flu is not a serious threat, but the elderly and those with...
Source: NHS News Feed - February 4, 2015 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Medical practice QA articles Source Type: news