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Nutrition: Zinc

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Total 98 results found since Jan 2013.

Serum/Plasma Zinc Is Apparently Increased in Ischemic Stroke: a Meta-analysis
Biol Trace Elem Res. 2021 Apr 6. doi: 10.1007/s12011-021-02703-4. Online ahead of print.ABSTRACTZinc (Zn) is found in many neuronal pathways in the brain and has implications for neuromodulation and cerebrovascular disease. However, the association between Zn levels and stroke risk remains controversial. Therefore, we conducted a meta-analysis to explore these relationships. A systematic literature search using PubMed, EMBASE database, and Google Scholar was performed for relevant articles from inception to August 2020. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were considered the effect sizes...
Source: Biological Trace Element Research - April 7, 2021 Category: Biology Authors: Mengyun Huang Lijun Zhu Yan Chen Yuelong Jin Zhengmei Fang Yingshui Yao Source Type: research

Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction
Eur J Med Chem. 2021 Mar 17;218:113383. doi: 10.1016/j.ejmech.2021.113383. Online ahead of print.ABSTRACTHistone deacetylase 6 (HDAC6) has become a promising therapeutic target for central nervous system diseases due to its more complex protein structure and biological functions. However, low brain penetration of reported HDAC6 inhibitors limits its clinical application in neurological disorders. Therefore, the benzazepine, a brain-penetrant rigid fragment, was utilized to design a series of selective HDAC6 inhibitors to improve brain bioavailability. Various synthetic strategies were applied to assemble the tetrahydro-ben...
Source: European Journal of Medicinal Chemistry - April 2, 2021 Category: Chemistry Authors: Zheng Guo Zixue Zhang Yi Zhang Guan Wang Ziyi Huang Qinwei Zhang Jianqi Li Source Type: research

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication
Conclusion These findings demonstrate how CCR5 gene–edited CD4+ T cell infusion could aid HIV cure strategies by augmenting preexisting HIV-specific immune responses.REGISTRATION ClinicalTrials.gov NCT02388594.Funding NIH funding (R01AI104400, UM1AI126620, U19AI149680, T32AI007632) was provided by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS). Sangamo Therapeutics also provided funding for these studies.
Source: Journal of Clinical Investigation - April 2, 2021 Category: Biomedical Science Authors: Pablo Tebas, Julie K. Jadlowsky, Pamela A. Shaw, Lifeng Tian, Erin Esparza, Andrea L. Brennan, Sukyung Kim, Soe Yu Naing, Max W. Richardson, Ashley N. Vogel, Colby R. Maldini, Hong Kong, Xiaojun Liu, Simon F. Lacey, Anya M. Bauer, Felicity Mampe, Lee P. R Source Type: research

Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma
In conclusion, we identified single nucleotide variants in theZBTB46 gene associated with a higher risk of parenchymal haematoma following recombinant tissue-plasminogen activator treatment.
Source: Brain - March 16, 2021 Category: Neurology Source Type: research

Fish, Cardiovascular Disease, and Mortality
Fish and shellfish (hereafter referred to as fish) are major sources of the dietary long-chain ω-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) and also contain other nutrients, such as vitamin D, riboflavin, iodine, calcium, phosphorus, magnesium, potassium, zinc, and iron. The summed results of observational studies of fish intake, randomized clinical tria ls of fish oil supplements, and associated mechanistic and experimental studies suggest that regular fish consumption may decrease the incidence of myocardial infarction (MI) and coronary heart disease (CHD), with more uncertain effec...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research

U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells.
Abstract Deafness is the most common sensory disorder in the world. Ototoxic drugs are common inducing factors of sensorineural hearing loss, and cochlear hair cell (HC) damage is the main concern of the present studies. Cisplatin is a widely used, highly effective antitumor drug, but some patients have experienced irreversible hearing loss as a result of its application. This hearing loss is closely related to HC apoptosis and autophagy. U0126 is a specific inhibitor of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signaling pathway and has neuroprotective effects. For example, the neuroprot...
Source: Toxicology and Applied Pharmacology - February 9, 2021 Category: Toxicology Authors: Wang D, Shi S, Ren T, Zhang Y, Guo P, Wang J, Wang W Tags: Toxicol Appl Pharmacol Source Type: research

Transcription of CLDND1 in human brain endothelial cells is regulated by the myeloid zinc finger protein 1.
Abstract Increased permeability of endothelial cells lining the blood vessels in the brain leads to vascular oedema and, potentially, to stroke. The tight junctions (TJs), primarily responsible for the regulation of vascular permeability, are multi-protein complexes comprising the claudin family of proteins and occludin. Several studies have reported that downregulation of the claudin domain containing 1 (CLDND1) gene enhances vascular permeability, which consequently increases the risk of stroke. However, the transcriptional regulation of CLDND1 has not been studied extensively. Therefore, this study aimed to ide...
Source: Clinical and Experimental Pharmacology and Physiology - October 9, 2020 Category: Drugs & Pharmacology Authors: Shima A, Matsuoka H, Yamaoka A, Michihara A Tags: Clin Exp Pharmacol Physiol Source Type: research

Matrix Metalloproteinases in Acute Intracerebral Hemorrhage
AbstractSpontaneous intracerebral hemorrhage (ICH) accounts for 10 –30% of all strokes and affects more than one million people every year worldwide, and it is the stroke subtype associated with the highest rates of mortality and residual disability. So far, clinical trials have mainly targeted primary cerebral injury and have substantially failed to improve clin ical outcomes. The understanding of the pathophysiology of early and delayed injury after ICH is, hence, of paramount importance to identify potential targets of intervention and develop effective therapeutic strategies. Matrix metalloproteinases (MMPs) represen...
Source: Neurotherapeutics - January 22, 2020 Category: Neurology Source Type: research

Role of Zinc Supplementation on Ischemia/Reperfusion Injury in Various Organs.
Abstract Ischemia-reperfusion (I/R) injury is a serious condition which is associated with myocardial infarction, stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease, and sleep apnea and can lead to high morbidity and mortality. Salts of zinc (Zn) are commonly used by humans and have protective effects against gastric, renal, hepatic, muscle, myocardial, or neuronal ischemic injury. The present review evaluates molecular mechanisms underlying the protective effects of Zn supplement against I/R injury. Data of this review have been collected from the scientific articles published in databas...
Source: Biological Trace Element Research - December 10, 2019 Category: Biology Authors: Akbari G Tags: Biol Trace Elem Res Source Type: research

Role of Adipokine Zinc- α-2-glycoprotein in Coronary Heart Disease.
In this study, the role of AZGP1 in atherosclerosis and CHD was investigated. Serum AZGP1 levels from control (n=84) and CHD (n=91) patients were examined by ELISA and its relationship with various clinical parameters was analyzed. Immunohistochemistry and immunofluorescence were used to detect the expression of AZGP1 and its receptor in coronary atherosclerotic arteries. THP-1 and HEK293 cells were used to verify its anti-inflammatory role in atherosclerosis. Serum AZGP1 levels in CHD patients were lower than controls (P < 0.01) and independently associated with CHD prevalence (P= 0.021). AZGP1 levels also inversely co...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 16, 2019 Category: Physiology Authors: Huang D, Mao X, Peng J, Cheng M, Bai T, Du M, Huang K, Liu B, Yang L, Huang K, Zhang F Tags: Am J Physiol Endocrinol Metab Source Type: research

Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience From a Tertiary Care Hospital in North India*
Conclusions: We observed a high prevalence of critical illness polyneuropathy in children in PICU, mechanically ventilated for 7 days or more; almost all of whom had underlying sepsis.
Source: Pediatric Critical Care Medicine - September 1, 2019 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Two phosphonium cation-based ionic liquids as lubricant additive to a polyalphaolefin base oil
Publication date: 1 November 2019Source: Journal of Molecular Liquids, Volume 293Author(s): R. González, J.L. Viesca, A. Hernández Battez, M. Hadfield, A. Fernández-González, M. BartoloméAbstractThis paper studies the tribological performance of two phosphonium cation-based ionic liquids: trihexyltetradecylphosphonium bis(2,4,4-trimethylpentyl) phosphinate ([P6,6,6,14][(iC8)2PO2]) and trihexyltetradecylphosphonium bis(2-ethylhexyl) phosphate ([P6,6,6,14][BEHP]), as lubricant additive at 1 wt% to a polyalphaolefin. A comparison of their tribological behavior was made to that of one type of zinc dialkyldithiophosphate...
Source: Journal of Molecular Liquids - August 17, 2019 Category: Molecular Biology Source Type: research

MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.
In conclusion, our data reveal a novel role of miR-191 in promoting ischemic brain injury through inhibiting angiogenesis via targeting VEZF1. Therefore, miR-191 may serve as a biomarker or a therapeutic target for AIS. PMID: 31064890 [PubMed - as supplied by publisher]
Source: Aging - May 6, 2019 Category: Biomedical Science Authors: Du K, Zhao C, Wang L, Wang Y, Zhang KZ, Shen XY, Sun HX, Gao W, Lu X Tags: Aging (Albany NY) Source Type: research

“Zinc homeostasis and zinc signaling in white matter development and injury”
Publication date: Available online 4 May 2019Source: Neuroscience LettersAuthor(s): Christopher ElittAbstractZinc in an essential dietary micronutrient that is abundant in the brain with diverse roles in development, injury and neurological diseases. With new imaging tools and chelators selectively targetingzinc, the field of zinc biology is rapidly expanding. The importance ofzinc homeostasis is now well recognized in neurodegeneration but there isemerging data that zinc may be equally important in white matterdisorders. This review provides an overview on zinc biology, includingdiscussion of clinical disorders of zinc de...
Source: Neuroscience Letters - May 4, 2019 Category: Neuroscience Source Type: research