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Nutrition: Zinc

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Total 98 results found since Jan 2013.

Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1 α/VEGF signaling pathway in experimental stroke
CONCLUSIONS: Zinc significantly improves neurological function recovery during the cerebral ischemia repair stage, providing new evidence supporting zinc as a potential therapeutic target for ischemic stroke by promoting astrocyte induced angiogenesis.PMID:35855611 | DOI:10.1111/cns.13918
Source: CNS Neuroscience and Therapeutics - July 20, 2022 Category: Neuroscience Authors: Yang Li Tingting Ma Xiaoyu Zhu Mingqi Zhang Liang Zhao Peng Wang Jia Liang Source Type: research

What the Science Says About the Health Benefits of Vitamins and Supplements
From multivitamins and melatonin to fiber and fish oil, Americans who are trying to boost their health and immunity have a plethora of supplements to choose from. An estimated 58% of U.S. adults ages 20 and over take dietary supplements, according to the U.S. Centers for Disease Control and Prevention, and the supplement industry is valued at more than $30 billion a year. Supplement use has been growing rapidly over the past few decades along with the wellness industry. “The popular belief is that a supplement is going to be helpful for promoting health,” says Fang Fang Zhang, a professor at Tufts University&rs...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news

Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke
In conclusion, Zfp580 differentially controls paracrine and endocrine Igf1 and Igfbp3 after stroke. Inhibition of Zfp580 might be a new treatment target leading to increased activity of Igf1 to improve stroke outcome.
Source: Frontiers in Physiology - April 26, 2022 Category: Physiology Source Type: research

Reversible Hydration Composite Films for Evaporative Perspiration Control and Heat Stress Management
A super-hygroscopic zinc-poly(vinyl alcohol) composite film is developed to improve thermal comfort for healthcare workers. With the composite film attached to the personal protective equipment, the water vapor accumulated is rapidly absorbed by the film. A steep vapor pressure gradient is created to facilitate sweat evaporation and relieve the heat stress experienced by healthcare workers. AbstractDonning of personal protective equipment (PPE) in the healthcare sector has been intensified by the on-going COVID-19 pandemic around the globe. While extensive PPE provides protection, it typically limits moisture permeability ...
Source: Small - February 21, 2022 Category: Nanotechnology Authors: Jiachen Yang, Xueping Zhang, J. Justin Koh, Rensheng Deng, Saravana Kumarasamy, Yuan Xing Xu, Hao Qu, Songlin Zhang, Yaoxin Zhang, Swee Ching Tan Tags: Research Article Source Type: research

Differential associations of particle size ranges and constituents with stroke emergency-room visits in Shanghai, China
CONCLUSION: Ultra-fine particles and some PM2.5 constituents (i.e., carbonaceous fractions, inorganic ions and some elements) may be mainly responsible for the excess risk of stroke induced by PM2.5.PMID:35104777 | DOI:10.1016/j.ecoenv.2022.113237
Source: Ecotoxicology and Environmental Safety - February 1, 2022 Category: Environmental Health Authors: Yuhao Zhang Qinglin He Yaping Zhang Xiaowei Xue Haidong Kan Xin Wang Source Type: research

Circ_0006768 upregulation attenuates oxygen –glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell injuries by upregulating VEZF1 via miR-222-3p inhibition
This study aimed to explore the function and functional mechanism of circ_0006768 in oxygen –glucose deprivation/reoxygenation (OGD/R)-induced brain injury models of ischemic stroke. Human brain microvascular endothelial cells (HBMECs) were induced by OGD/R to mimic ischemic stroke models in vitro. The expression of circ_0006768, microRNA-222-3p (miR-222-3p) and vascular endothelial zinc finger 1 (VEZF1) was detected by quantitative real-time PCR (qPCR). Cell viability, angiogenesis ability and cell migration were assessed by cell counting kit-8 (CCK-8) assay, tube formation assay and wound healing assay, respectively. T...
Source: Metabolic Brain Disease - November 15, 2021 Category: Neurology Source Type: research

Metal ion chelation enhances tissue plasminogen activator (tPA)-induced thrombolysis: an in vitro and in vivo study
AbstractStroke is the third leading cause of death in the United States and the leading cause of adult disability. Despite enormous research efforts including many clinical trials, tissue plasminogen activator (tPA) remains the only FDA-approved treatment for acute ischemic stroke. Unfortunately, only 1 –3% of stroke patients in the US receive this therapy because of the narrow time window and severe side effects for using tPA. The most deadly and damaging side effect is the risk of intracranial bleeding or hemorrhage. For that reason, the dose of tPA and its overall administration are under tigh t control, which may com...
Source: Journal of Thrombosis and Thrombolysis - November 10, 2021 Category: Hematology Source Type: research

Tetramethylpyrazine Preserves the Integrity of Blood-Brain Barrier Associated With Upregulation of MCPIP1 in a Murine Model of Focal Ischemic Stroke
Tetramethylpyrazine (TMP), a prominent ingredient of Chinese herb Ligusticum chuanxiong Hort, is known to suppress neuroinflammation and protect blood-brain barrier (BBB) integrity. We investigated whether monocyte chemotactic protein-induced protein 1 (MCPIP1, also known as Regnase-1), a newly identified zinc-finger protein, plays a role in TMP-mediated anti-inflammation and neuroprotection. Male C57BL/6 mice were subjected to focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) for 2 h, followed by reperfusion for 24 h. TMP (25 mg/kg or 50 mg/kg) or vehicle was administered intraperitoneally 12Â...
Source: Frontiers in Pharmacology - July 28, 2021 Category: Drugs & Pharmacology Source Type: research

Circ_0006768 upregulation attenuates oxygen –glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell injuries by upregulating VEZF1 via miR-222-3p inhibition
This study aimed to explore the function and functional mechanism of circ_0006768 in oxygen –glucose deprivation/reoxygenation (OGD/R)-induced brain injury models of ischemic stroke. Human brain microvascular endothelial cells (HBMECs) were induced by OGD/R to mimic ischemic stroke models in vitro. The expression of circ_0006768, microRNA-222-3p (miR-222-3p) and vascular endothelial zinc finger 1 (VEZF1) was detected by quantitative real-time PCR (qPCR). Cell viability, angiogenesis ability and cell migration were assessed by cell counting kit-8 (CCK-8) assay, tube formation assay and wound healing assay, respectively. T...
Source: Metabolic Brain Disease - June 19, 2021 Category: Neurology Source Type: research

Cardiovascular injuries during COVID-19 infection: A PROCESS-compliant case series from the Eastern Morocco
CONCLUSION: Cardiovascular involvement during COVID-19 should not be neglected and are associated with severe outcomes.PMID:33898022 | PMC:PMC8053362 | DOI:10.1016/j.amsu.2021.102309
Source: Annals of Medicine - April 26, 2021 Category: Internal Medicine Authors: Abdelilah El Rhalete Inas Rhazi Amine Bensaid Ikram Zaid Houssam Bkiyer Nabila Ismaili Nouha Elouafi Brahim Housni Source Type: research

Serum/Plasma Zinc Is Apparently Increased in Ischemic Stroke: a Meta-analysis
Biol Trace Elem Res. 2021 Apr 6. doi: 10.1007/s12011-021-02703-4. Online ahead of print.ABSTRACTZinc (Zn) is found in many neuronal pathways in the brain and has implications for neuromodulation and cerebrovascular disease. However, the association between Zn levels and stroke risk remains controversial. Therefore, we conducted a meta-analysis to explore these relationships. A systematic literature search using PubMed, EMBASE database, and Google Scholar was performed for relevant articles from inception to August 2020. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were considered the effect sizes...
Source: Biological Trace Element Research - April 7, 2021 Category: Biology Authors: Mengyun Huang Lijun Zhu Yan Chen Yuelong Jin Zhengmei Fang Yingshui Yao Source Type: research