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Total 46 results found since Jan 2013.

Bioinformatic Analysis of Exosomal MicroRNAs of Cerebrospinal Fluid in Ischemic Stroke Rats After Physical Exercise
Neurochem Res. 2021 Mar 11. doi: 10.1007/s11064-021-03294-1. Online ahead of print.ABSTRACTPhysical exercise is beneficial to the structural and functional recovery of post-ischemic stroke, but its molecular mechanism remains obscure. Herein, we aimed to explore the underlying mechanism of exercise-induced neuroprotection from the perspective of microRNAs (miRNAs). Adult male Sprague-Dawley (SD) rats were randomly distributed into 4 groups, i.e., the physical exercise group with the transient middle cerebral artery occlusion (tMCAO) surgery (PE-IS, n = 28); the physical exercise group without tMCAO surgery (PE, n = 6); the...
Source: Neurochemical Research - March 12, 2021 Category: Neuroscience Authors: Mudan Huang Chongjun Xiao Liying Zhang Lili Li Jing Luo Lilin Chen Xiquan Hu Haiqing Zheng Source Type: research

Transcriptome Analysis Reveals the Effects of Troxerutin and Cerebroprotein Hydrolysate Injection on Injured Spinal Cords in Rats.
In this study, the effects of administering TCH injections on neurological recovery in post-SCI rats were first tested with regard to the behavior and histology; subsequently, the specific expression profile of mRNAs and long noncoding RNAs (LncRNAs) in their spinal cords were conducted using RNA sequencing (RNA-seq). The LncRNA-mRNA networks were also elucidated. After SCI, we found that TCH injection with the right dose is effective for the recovery of locomotion function and repairing of the damaged tissue in the spinal cord; TCH injection is also discovered to have a role in the regulation of 443 differentially express...
Source: Evidence-based Complementary and Alternative Medicine - August 25, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Reduced thiamine is a predictor for cognitive impairment of cerebral infarction
ConclusionsReduced thiamine is one of the predictors for early cognitive impairment in patients with acute cerebral infarction.
Source: Brain and Behavior - August 4, 2020 Category: Neurology Authors: Liang Feng, Weilei He, Guiqian Huang, Shasha Lin, Chengxiang Yuan, Haoran Cheng, Jincai He, Yiming Liu Tags: ORIGINAL RESEARCH Source Type: research

Stroke as an initial manifestation of thiamine-responsive megaloblastic anemia
Priyanka Madaan, Prashant Jauhari, Shruthi N Michael, Aditi Sinha, Biswaroop Chakrabarty, Sheffali GulatiAnnals of Indian Academy of Neurology 2020 23(1):136-138
Source: Annals of Indian Academy of Neurology - January 20, 2020 Category: Neurology Authors: Priyanka Madaan Prashant Jauhari Shruthi N Michael Aditi Sinha Biswaroop Chakrabarty Sheffali Gulati Source Type: research

Mitochondrial A3243G mutation causes mitochondrial encephalomyopathy in a Chinese patient: Case report
Rationale: Mitochondrial mutations are associated with a wide spectrum of clinical abnormalities. More than half of these mutations are distributed in the 22 mitochondrial tRNA genes, including tRNALeu(UUR). In particular, the A3243G mutation in the tRNALeu(UUR) gene causes mitochondrial encephalomyopathy. Patient concerns: A 12-year-old boy was admitted to Shaoxing People's Hospital because there is a reduction in the volume of speech, dysphonia, unable to write, recognize words, and unable to wear clothes, accompanied by unstable walking after treatment of unexplained fever and somnolence. Diagnoses: The proband ...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Brachytherapy of tongue carcinoma in a patient with difficult airway: anesthetic considerations.
We report a 74-year-old chronic smoker, chronic alcoholic with history of stroke, who had undergone brachytherapy for tongue carcinoma. Apart from a huge tongue tumor, he had an epiglottic mass but refused elective tracheostomy. This had led to a few critical states throughout the process of treatment, including a metabolic crisis due to thiamine deficiency and difficult airway crisis. To our best knowledge, there have been no reported case on a patient with vocal cord mass undergoing tongue brachytherapy. We hope sharing of this experience may aid the management of similar patients in future. PMID: 30662482 [PubMed]
Source: Journal of Contemporary Brachytherapy - January 23, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Relationship Between Nutritional Factors and Hip Bone Density in Individuals with Chronic Stroke
AbstractThe aim of this study was to investigate the relationship between dietary habits and hip bone health in community-dwelling individuals with chronic stroke. The usual dietary intake of 94 individuals with chronic stroke (30 women, mean age: 59.0  years) was assessed by a 3-day food record within a single week. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at both hips. The results showed that low hip bone mass was found in 59 and 50 of the participants on the affected and unaffected side, respectively. The mean hip BMD was also significantly lower on the affected side than the unaf...
Source: Calcified Tissue International - April 17, 2017 Category: Orthopaedics Source Type: research

Alcoholic cardiomyopathy : The result of dosage and individual predisposition.
Authors: Maisch B Abstract The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person's health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites. Historical exa...
Source: Herz - September 3, 2016 Category: Cardiology Tags: Herz Source Type: research

Thiamine Deficiency Presenting as Intraventricular Hemorrhage Illustrative Teaching Case
Source: Stroke - May 22, 2016 Category: Neurology Authors: Al-Bayati, A. R., Nichols, J., Jovin, T. G., Jadhav, A. P. Tags: Diet and Nutrition, Cognitive Impairment, Intracranial Hemorrhage Illustrative Teaching Case Source Type: research

Thiamine Deficiency While on Total Parenteral Nutrition Mimicking Acute Stroke: A Case Report (P3.217)
CONCLUSIONS: Thiamine deficiency mimicking stroke while on total parenteral nutrition has been rarely documented. Recognition of this syndrome is critical as prompt treatment may reverse symptoms.Disclosure: Dr. Parker has nothing to disclose. Dr. Marafie has nothing to disclose. Dr. Wolf has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Parker, A., Marafie, D., Wolf, V. Tags: Neurocritical Care: Clinical Science and Therapeutics Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Got PMS? You Might Have High Blood Pressure In The Future, Says Study
By: Agata Blaszczak Boxe Published: 11/25/2015 10:14 AM EST on LiveScience The headaches, fatigue and other symptoms of premenstrual syndrome may be more than just a monthly aggravation — they may also signal greater future health problems for those women suffering from the syndrome: Women who have PMS may have an increased risk of developing high blood pressure in the future, according to a new study. Researchers found that the women who had PMS at the beginning of the study were 40 percent more likely to develop high blood pressure over the next 20 years, compared to women who experienced few menstrual symptom...
Source: Science - The Huffington Post - November 26, 2015 Category: Science Source Type: news

Fluctuating Mental Status and Fever of Unknown Origin (P1.030)
Conclusion: Central nervous system involvement as the initial manifestation of microscopic polyangiitis is rare and can result in a challenging clinical picture including recurrent ischemic strokes.Disclosure: Dr. Daniel has nothing to disclose. Dr. Brink has nothing to disclose. Dr. Hosley has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Daniel, A., Brink, J., Hosley, C. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Genetic Implication of a Novel Thiamine Transporter in Human Hypertension
ConclusionsNovel strategies were coupled to position a new hypertension-susceptibility locus, uncovering a previously unsuspected thiamine transporter whose genetic variants predicted several disturbances in cardiac and autonomic function. The results have implications for the pathogenesis and treatment of systemic hypertension.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - April 14, 2014 Category: Radiology Source Type: research

Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases
Conclusions As thiamine deficiency is frequently associated with alcoholism, malnutrition and prolonged vomiting; we recommend prompt treatment of MBD with parenteral thiamine in such subjects. Recovery should be followed by repeated neuropsychological and MRI examinations, preferably using diffusion tensor imaging.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 17, 2014 Category: Neurosurgery Authors: Hillbom, M., Saloheimo, P., Fujioka, S., Wszolek, Z. K., Juvela, S., Leone, M. A. Tags: Epilepsy and seizures, Neuroimaging, Stroke, Alcohol-related disorders, Drugs misuse (including addiction), Radiology, Radiology (diagnostics) Neuropsychiatry Source Type: research