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An undefined cystatin CsCPI1 from tea plant Camellia sinensis harbors antithrombotic activity
Biomed Pharmacother. 2023 Jan 25;159:114285. doi: 10.1016/j.biopha.2023.114285. Online ahead of print.ABSTRACTTea consumption has been linked to a decreased risk of cardiovascular disease (CVD) mortality, which imposes a heavy burden on the healthcare system; however, which components in tea cause this beneficial effect is not fully understood. Here we uncovered a cystatin (namely CsCPI1), which is a cysteine proteinase inhibitor (CPI) of the tea plant (Camellia sinensis) that promotes antithrombotic activity. Since thrombosis is a common pathogenesis of fatal CVDs, we investigated the effects of CsCPI1, which showed good ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 27, 2023 Category: Drugs & Pharmacology Authors: Mingqian Fang Jong-Ho Cha Hao-Ching Wang Peng Ye Bi Chen Mengrou Chen Wen-Hao Yang Xiuwen Yan Source Type: research

Drinking Black Tea May Lower Mortality Risk, Study Suggests
While green tea has a long-standing reputation for health benefits, research has been much more mixed on black tea. One problem, says Maki Inoue-Choi, an epidemiologist at the National Cancer Institute, is that large observational studies on tea and mortality have focused on countries like Japan or China—places where green tea is more popular. To fill this gap, Inoue-Choi and her colleagues analyzed data in the United Kingdom, where black tea drinking is common. After surveying about 500,000 people and following them for a median of 11 years, the results, published Aug. 29 in the journal Annals of Internal Medicine, ...
Source: TIME: Health - August 29, 2022 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news

Non-alcoholic beverages intake and risk of cardiovascular disease among Japanese men and women: the JPHC study
In conclusion, the risks of stroke and total cardiovascular disease were lower with a higher intake of non-alcoholic beverages in Japanese men and women.PMID:34284829 | DOI:10.1017/S0007114521002737
Source: The British Journal of Nutrition - July 21, 2021 Category: Nutrition Authors: Renzhe Cui Hiroyasu Iso Ehab S Eshak Koutatsu Maruyama Junko Ishihara Ribeka Takachi Norie Sawada Shoichiro Tsugane JPHC Study Group Source Type: research

Tea consumption and risk of stroke in Chinese adults: a prospective cohort study of 0.5 million men and women.
CONCLUSIONS: Among Chinese adults, higher consumption of tea, especially green tea, was associated with a lower risk of ischemic and hemorrhagic stroke. PMID: 31711152 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - November 10, 2019 Category: Nutrition Authors: Tian T, Lv J, Jin G, Yu C, Guo Y, Bian Z, Yang L, Chen Y, Shen H, Chen Z, Hu Z, Li L, China Kadoorie Biobank Collaborative Group Tags: Am J Clin Nutr Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Supplementation with different teas from Camellia sinensis prevents memory deficits and hippocampus oxidative stress in ischemia-reperfusion
Publication date: September 2017 Source:Neurochemistry International, Volume 108 Author(s): Alexandre Martins, Helen L. Schimidt, Alexandre Garcia, Caroline Dalla Colletta Altermann, Francielli W. Santos, Felipe P. Carpes, Weber Cláudio da Silva, Pâmela B. Mello-Carpes Memory and cognition impairments resultant of ischemic stroke could be minimized or avoided by antioxidant supplementation. In this regard, the neuroprotective potential of Green tea from Camellia sinensis has been investigated. However, there is a lack of information regarding the neuroprotective potential of others teas processed from the Camellia sinen...
Source: Neurochemistry International - July 13, 2017 Category: Neuroscience Source Type: research

Green tea consumption and risk of cardiovascular disease or stroke
Pang et al. evaluated the association between green tea consumption and the risk of cardiovascular disease (CVD) or ischemic related diseases, and a total of 9 studies on Japanese were included for their meta-analysis [1]. Odds ratios (ORs) (95% confidence intervals (CIs)) of those who didn't consume green tea for CVD, intracerebral hemorrhage, and cerebral infarction were 1.19 (1.09–1.29), 1.24 (1.03–1.49), and 1.15 (1.01–1.30) compared to
Source: International Journal of Cardiology - July 8, 2016 Category: Cardiology Authors: Tomoyuki Kawada Tags: Correspondence Source Type: research

Delayed Treatment with Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice
In this study, C57BL/6 mice underwent middle cerebral artery occlusion (60 min) followed by reperfusion for 28 days. Neural progenitor cells (NPCs) were isolated from ipsilateral subventricular zone (SVZ) at 14 days post-ischemia (dpi). The effects of EGCG on the proliferation and differentiation of NPCs were examined in vivo and in vitro. Behavioral assessments were made 3 days before MCAO and at 28 dpi. SVZ NPCs were stimulated with lipopolysaccharide (LPS) in vitro to mimic the inflammatory response after ischemic stroke. We found that 14 days treatment with EGCG significantly increased the proliferation of SVZ NP...
Source: Molecular Neurobiology - May 19, 2016 Category: Neurology Source Type: research

Antidepressive‐like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post‐stroke depression
ConclusionsThis work represents the first attempt to demonstrate the positive effect of tea, and especially GGT, on post‐stroke depression and to correlate this effect with the antioxidant activity and phytochemical composition of tea.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - December 2, 2015 Category: Food Science Authors: Arianna Di Lorenzo, Seyed Fazel Nabavi, Antoni Sureda, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani, Patrizia Arcidiaco, Seyed Mohammad Nabavi, Maria Daglia Tags: Research Article Source Type: research

Memory deficits and oxidative stress in cerebral ischemia-reperfusion: Neuroprotective role of physical exercise and green tea supplementation.
Abstract Ischemic stroke is a major cause of morbidity and mortality all over the world. Among impairments observed in survivors there is a significant cognitive learning and memory deficit. Neuroprotective strategies are being investigated to minimize such deficits after an ischemia event. Here we investigated the neuroprotective potential of physical exercise and green tea in an animal model of ischemia-reperfusion. Eighty male rats were divided in 8 groups and submitted to either transient brain ischemia-reperfusion or a sham surgery after 8 weeks of physical exercise and/or green tea supplementation. Ischemia-...
Source: Neurobiology of Learning and Memory - July 22, 2014 Category: Neurology Authors: Schimidt HL, Vieira A, Altermann C, Martins A, Sosa P, Santos FW, Mello-Carpes PB, Izquierdo I, Carpes FP Tags: Neurobiol Learn Mem Source Type: research

Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling
Conclusions: These results demonstrate that GTPs may act as a potential neuroprotective agent against BBB damage at the early stage of focal cerebral ischemia through the regulation of TJ and PKCalpha signaling.
Source: BMC Complementary and Alternative Medicine - July 21, 2013 Category: Complementary Medicine Authors: Xiaobai LiuZhenhua WangPing WangBo YuYunhui LiuYixue Xue Source Type: research