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MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and various in silico bioinformatics tools
Conclusion In conclusion, the results of this study proved that PMEAF is a promising anticancer agent with high cytotoxicity against MDA-MB-231 breast cancer cells and it induced apoptotic cell death mechanism through the regulation of miRNAs. PMEAF might be the best candidate for developing more potent anticancer drugs or chemo preventive supplements. Graphical abstract
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Dietary patterns and retinal vessel caliber in the Irish Nun Eye Study
ConclusionIn this cohort of older women with a restricted lifestyle, an unhealthy DP was independently associated with an unfavorable retinal profile, namely a widening of retinal venules and narrowing of retinal arterioles. Key words: Dietary
Source: The Journal of Nutrition, Health and Aging - December 5, 2017 Category: Nutrition Source Type: research

Future trials on endovascular stroke treatment: the not-so-easy-to-pluck fruits
Source: Neuroradiology - December 23, 2017 Category: Radiology Source Type: research

Nutrients intake, and serum calcium and phosphorus levels: An evidence ‐based study
ConclusionWe found that the dietary intake of Ca was not sufficient in our population and was associated with the dietary intake of some macro‐ and micronutrient, supporting further investigation on clinical impact of this condition on calcium/phosphorus deficiency related diseases.
Source: Journal of Clinical Laboratory Analysis - November 7, 2017 Category: Laboratory Medicine Authors: Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A. Ferns, Majid Ghayour Mobarhan Tags: RESEARCH ARTICLE Source Type: research

Diet shown to reduce stroke risk may also reduce risk of depression
(American Academy of Neurology) MINNEAPOLIS - People who eat vegetables, fruit and whole grains may have lower rates of depression over time, according to a preliminary study released today that will be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.
Source: EurekAlert! - Medicine and Health - February 25, 2018 Category: International Medicine & Public Health Source Type: news

Research trends in flavonoids and health.
Abstract Herein we describe, based on some bibliometric data, how the field of research on flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen in an exponential manner over these years, much faster than other fields on food constituents. This increase appears to be related to the contemporary explosion of interest in healthy foods, supplements and nutraceuticals. It was also probably triggered by large epidemiological studies on fruits and vegetables, and particularly on flavonoids, consumption and incidence of cancer, stroke and coronary heart disease. The widely distribute...
Source: Archives of Biochemistry and Biophysics - March 23, 2018 Category: Biochemistry Authors: Perez-Vizcaino F, Fraga CG Tags: Arch Biochem Biophys Source Type: research

Flying Drosophila maintain arbitrary but stable headings relative to the angle of polarized light RESEARCH ARTICLE
In this study, we investigated how the fruit fly, Drosophila melanogaster, selects and maintains a flight heading relative to the axis of linearly polarized light, a visual cue produced by the atmospheric scattering of sunlight. To track flies’ headings over extended periods, we used a flight simulator that coupled the angular velocity of dorsally presented polarized light to the stroke amplitude difference of the animal's wings. In the simulator, most flies actively maintained a stable heading relative to the axis of polarized light for the duration of 15 minute flights. We found that individuals selected arbitrary,...
Source: Journal of Experimental Biology - March 28, 2018 Category: Biology Authors: Warren, T. L., Weir, P. T., Dickinson, M. H. Tags: RESEARCH ARTICLE Source Type: research

Finding Good Candidates for Risk-Sharing Arrangements
Continued from Part I that discusses the tools device manufacturers can use to manage risk How to find good candidates? Not all devices are created equal. But how can device manufacturers identify the low-hanging fruit for a risk-sharing arrangement? Needless to say, the more characteristics a product has that are associated with successful risk-sharing arrangements, the more such an arrangement is likely to succeed. To illustrate, in Exhibit 1, we chart a select number of risk-sharing arrangements established since 2015 along two key dimensions: product effectiveness and time needed to observe expected outcomes. The findi...
Source: MDDI - April 3, 2018 Category: Medical Devices Authors: Harry Liu and Christine Chen Tags: Contract Manufacturing Design Source Type: news

A Man Got ‘Thunderclap Headaches’ After Eating the World’s Hottest Pepper
This article originally appeared on Health.com
Source: TIME: Health - April 10, 2018 Category: Consumer Health News Authors: Amanda Macmillan / Health.com Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news

Reprint of: Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease.
Abstract Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA). The main dietary source of EPA and DHA for human cons...
Source: Fitoterapia - April 12, 2018 Category: Biochemistry Authors: Mori TA Tags: Fitoterapia Source Type: research

Flying Drosophila melanogaster maintain arbitrary but stable headings relative to the angle of polarized light RESEARCH ARTICLE
In this study, we investigated how the fruit fly Drosophila melanogaster selects and maintains a flight heading relative to the axis of linearly polarized light, a visual cue produced by the atmospheric scattering of sunlight. To track flies' headings over extended periods, we used a flight simulator that coupled the angular velocity of dorsally presented polarized light to the stroke amplitude difference of the animals’ wings. In the simulator, most flies actively maintained a stable heading relative to the axis of polarized light for the duration of 15 min flights. We found that individuals selected arbitrary,...
Source: Journal of Experimental Biology - May 11, 2018 Category: Biology Authors: Warren, T. L., Weir, P. T., Dickinson, M. H. Tags: Neuroethology RESEARCH ARTICLE Source Type: research

Surveillance for Certain Health Behaviors and Conditions Among States and Selected Local Areas - Behavioral Risk Factor Surveillance System, United States, 2015.
This report presents results for all 50 states, the District of Columbia, the Commonwealth of Puerto Rico (Puerto Rico), and Guam and for 130 metropolitan and micropolitan statistical areas (MMSAs) (N = 441,456 respondents) for 2015. RESULTS: The age-adjusted prevalence estimates of health-risk behaviors, self-reported chronic health conditions, access to and use of health care, and use of preventive health services varied substantially by state, territory, and MMSA in 2015. Results are summarized for selected BRFSS measures. Each set of proportions refers to the median (range) of age-adjusted prevalence estimates for...
Source: MMWR Surveill Summ - June 29, 2018 Category: Epidemiology Authors: Pickens CM, Pierannunzi C, Garvin W, Town M Tags: MMWR Surveill Summ Source Type: research

Fruit fly mating driven by a tweak in specific brain circuit
(NIH/National Institute of Neurological Disorders and Stroke) According to a new National Institutes of Health-funded study, it is not destiny that brings two fruit flies together, but an evolutionary matchmaker of sorts that made tiny adjustments to their brains' mating circuits, so they would be attracted to one another while rejecting advances from other, even closely-related, species. The results, published in Nature, may help explain how a specific female scent triggers completely different responses in different male flies.
Source: EurekAlert! - Medicine and Health - July 16, 2018 Category: International Medicine & Public Health Source Type: news

Mediterranean diet could lower stroke risk, especially for women: Study
The diet focuses on fruits, vegetables, nuts, fish and unsaturated fats.
Source: ABC News: Health - September 20, 2018 Category: Consumer Health News Tags: Health Source Type: news

Tannins and Vascular Complications of Diabetes: An update
ConclusionThis review focuses on the role of various tannins in prevention and management of diabetic complications like diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic cardiomyopathy. It will researchers to find some leads for the development of new cost effective therapy using dietary source for the management of diabetic complications.Graphical abstract
Source: Phytomedicine - October 23, 2018 Category: Drugs & Pharmacology Source Type: research