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Association of obesity and diabetes with physical activity and fruit and vegetable consumption in stroke survivors
ConclusionsResults indicated a joint effect of obesity and diabetes with low PA among stroke survivors. Regardless of obesity –diabetes status, however, prevalence of low FV consumption and low PA exceeded 50%. Targeted interventions that modify these unhealthy behaviours among stroke survivors should be explored.
Source: Family Practice - September 24, 2020 Category: Primary Care Source Type: research

Stroke Prevention: Little-Known and Neglected Aspects
Combining available therapies has the potential to reduce the risk of stroke by 80% or more. A comprehensive review of all aspects of stroke prevention would be very lengthy; in this narrative review, we focus on some aspects of stroke prevention that are little-known and/or neglected. These include the following: (1) implementation of a Mediterranean diet; (2) B vitamins to lower homocysteine; (3) coordinated approaches to smoking cessation; (4) intensive lipid-lowering therapy; (5) lipid lowering in the elderly; (6) physiologically individualized therapy for hypertension based on renin/aldosterone phenotyping; (7) avoidi...
Source: Cerebrovascular Diseases - May 27, 2021 Category: Neurology Source Type: research

Consumption of coffee and tea and risk of developing stroke, dementia, and poststroke dementia: A cohort study in the UK Biobank
by Yuan Zhang, Hongxi Yang, Shu Li, Wei-dong Li, Yaogang Wang BackgroundPrevious studies have revealed the involvement of coffee and tea in the development of stroke and dementia. However, little is known about the association between the combination of coffee and tea and the risk of stroke, dementia, and poststroke dementia. Therefore, we aimed to investigate the associations of coffee and tea separately and in combination with the risk of developing stroke and dementia. Methods and findingsThis prospective cohort study included 365,682 participants (50 to 74 years old) from the UK Biobank. Participants joined the study f...
Source: PLoS Medicine - November 16, 2021 Category: Internal Medicine Authors: Yuan Zhang Source Type: research

Nutrition in Stroke Prevention
Semin Neurol 2017; 37: 259-266 DOI: 10.1055/s-0037-1603470Nutrition is far more important to the prevention of stroke than most physicians realize. Key issues include a Mediterranean diet, the interaction of the intestinal microbiome, impaired renal function and diet, missed metabolic B12 deficiency, and the lowering of homocysteine with B vitamins to prevent stroke. The Cretan Mediterranean diet is high in olive oil, whole grains, fruits, vegetables, and legumes, and is close to a vegetarian diet. Compared with a low-fat diet, it reduced stroke by over 40%, and is clearly the best diet for diabetes. Metabolic B12 deficien...
Source: Seminars in Neurology - July 31, 2017 Category: Neurology Authors: Spence, J. David Tags: Review Article Source Type: research

Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
CONCLUSIONS: The present study demonstrates for the first time a graded relation between TMAO levels and the risk of subsequent cardiovascular events in patients with recent prior ischemic stroke. Our data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAO levels. PMID: 29976769 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 5, 2018 Category: Cardiology Authors: Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, Zhu W, Bavendiek U, Hazen SL, Endres M, Landmesser U Tags: Arterioscler Thromb Vasc Biol Source Type: research

Risk of second stroke can be reduced with prevention efforts based on cause of first stroke
(American Heart Association) Having a stroke caused by blocked blood vessels or a transient ischemic attack (TIA) greatly increases your chances of having a future stroke. Identifying the cause or causes of the first stroke is key to developing strategies to prevent additional strokes.Managing blood pressure levels, reducing or quitting smoking, eating a healthy diet, and regular physical activity will reduce the risk of a second stroke, along with managing conditions such as Type 2 diabetes and high cholesterol.
Source: EurekAlert! - Medicine and Health - May 24, 2021 Category: International Medicine & Public Health Source Type: news

Altered Jagged1-Notch1 Signaling in Enhanced Dysfunctional Neovascularization and Delayed Angiogenesis After Ischemic Stroke in HFD/STZ Induced Type 2 Diabetes Rats
This study was aimed to characterize structural alterations and potential mechanisms in brain microvessels before and after ischemic stroke in type 2 diabetic rats treated with high-fat diet and streptozotocin (HFD/STZ). Furtherly, we tested our hypothesis that dysregulated intercellular Jagged1-Notch1 signaling was involved in the dysfunctional cerebral neovascularization both before and after ischemic stroke in HFD/STZ rats. In our study, we found increased yet dysfunctional neovascularization with activated Jagged1-Notch1 signaling in the cerebrovasculature before cerebral ischemia in HFD/STZ rats compared with non-diab...
Source: Frontiers in Physiology - July 8, 2021 Category: Physiology Source Type: research

Association between dietary patterns and stroke in patients with type 2 diabetes mellitus in China: a propensity score-matched analysis
CONCLUSION: This study provides sufficient evidence to support the dietary intervention strategies to prevent stroke effectively. Maintaining a Balanced dietary pattern, especially with moderate consumption of foods rich in quality protein and fresh vegetables in T2DM patients, might decrease the risk of stroke in China.PMID:35356874 | DOI:10.1017/S1368980022000763
Source: Public Health Nutrition - March 31, 2022 Category: International Medicine & Public Health Authors: Chenlu He Wei Wang Qian Chen Ziyuan Shen Enchun Pan Zhongming Sun Peian Lou Xunbao Zhang Source Type: research

The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke
CONCLUSION: The study suggests that the prolonged effect of metformin-induced euglycemia promoted the microglial activation, reduced neuronal cell death, and improved the overall survival following stroke, without any change in infarct size.PMID:35792967 | DOI:10.1007/s43440-022-00382-z
Source: Pharmacological Reports - July 6, 2022 Category: Drugs & Pharmacology Authors: Rashmi Kumari Lisa Willing Scot R Kimball Ian A Simpson Source Type: research

Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options
Mediators Inflamm. 2022 Oct 11;2022:6508046. doi: 10.1155/2022/6508046. eCollection 2022.ABSTRACTThere has been a significant amount of interest in the past two decades in the study of the evolution of the gut microbiota, its internal and external impacts on the gut, and risk factors for cerebrovascular disorders such as cerebral ischemic stroke. The network of bidirectional communication between gut microorganisms and their host is known as the microbiota-gut-brain axis (MGBA). There is mounting evidence that maintaining gut microbiota homeostasis can frequently enhance the effectiveness of ischemic stroke treatment by mo...
Source: Atherosclerosis - October 21, 2022 Category: Cardiology Authors: Wenjing Huang Luwen Zhu Wenjing Song Mei Zhang Lili Teng Minmin Wu Source Type: research

High consumption of dairy products and risk of major adverse coronary events and stroke in a Swedish population
Br J Nutr. 2023 Sep 6:1-28. doi: 10.1017/S0007114523001939. Online ahead of print.ABSTRACTThe association between consumption of dairy products and risk of cardiovascular diseases (CVD) has been inconsistent. There is a lack of studies in populations with high intakes of dairy products. We aimed to examine the association between intake of dairy products and risk of incident major adverse coronary events and stroke in the Swedish Malmö Diet and Cancer cohort study. We included 26,190 participants without prevalent CVD or diabetes. Dietary habits were obtained from a modified diet history and endpoint data were extracted f...
Source: The British Journal of Nutrition - September 6, 2023 Category: Nutrition Authors: Justine Dukuzimana Suzanne Janzi Caroline Habberstad Shunming Zhang Yan Born é Emily Sonestedt Source Type: research