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Procedure: Perfusion
Nutrition: Calcium

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Total 43 results found since Jan 2013.

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Myogenic Tone as a Therapeutic Target for Ischemic Stroke.
Abstract Ischemic stroke causes vascular paralysis and impaired autoregulation in the brain, the degree of which is dependent on the depth and duration of ischemia and reperfusion (I/R). Ischemic stroke also impairs myogenic response of middle cerebral arteries (MCA) that may be an underlying mechanism by which autoregulation is impaired. Myogenic responses are affected by I/R through several mechanisms, including production of peroxynitrite, depolymerization of F-actin in vascular smooth muscle, and circulating vasoactive factors. The vascular endothelium is also significantly affected during focal ischemia that ...
Source: Current Vascular Pharmacology - September 25, 2013 Category: Drugs & Pharmacology Authors: Palomares SM, Cipolla MJ Tags: Curr Vasc Pharmacol Source Type: research

Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 1, 2015 Category: Neuroscience Authors: Zhiwei Tang, Shiping Li, Pengcheng Han, Junxiang Yin, Yan Gan, Qingwei Liu, Jinkun Wang, Chongqian Wang, Yu Li, Jiong Shi Tags: Original Article Source Type: research

Ivabradine is BEAUTIFUL in concurrent acute coronary syndrome and stroke
We report the safe use of oral ivabradine in 2 patients with concurrent ACS and stroke, achieving heart rate reduction and angina relief without affecting blood pressure.
Source: International Journal of Cardiology - September 20, 2012 Category: Cardiology Authors: Pow-Li Chia, David Foo Tags: Online letters to the Editor Source Type: research

Effect of Tight Glycemic Control on Patients with Ischemic Stroke.
Abstract Hyperglycemia in the setting of acute ischemic stroke is associated with increased mortality and worse neurological outcome.1 Multiple mechanisms exist by which hyperglycemia may worsen ischemic brain injury, including increased inflammatory stress, calcium imbalance, accumulation of reactive oxygen species, and decreased blood perfusion, but it is unclear if treating hyperglycemia can improve brain injury. PMID: 32426891 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - May 18, 2020 Category: Emergency Medicine Authors: Long B, Koyfman A, Gottlieb M Tags: Acad Emerg Med Source Type: research

Drug delivery to the ischemic brain.
Abstract Cerebral ischemia occurs when blood flow to the brain is insufficient to meet metabolic demand. This can result from cerebral artery occlusion that interrupts blood flow, limits CNS supply of oxygen and glucose, and causes an infarction/ischemic stroke. Ischemia initiates a cascade of molecular events in neurons and cerebrovascular endothelial cells including energy depletion, dissipation of ion gradients, calcium overload, excitotoxicity, oxidative stress, and accumulation of ions and fluid. Blood-brain barrier (BBB) disruption is associated with cerebral ischemia and leads to vasogenic edema, a primary ...
Source: Advances in Pharmacology - October 15, 2014 Category: Drugs & Pharmacology Authors: Thompson BJ, Ronaldson PT Tags: Adv Pharmacol Source Type: research

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Acute Intravenous Calcium Antagonist for Suspected Hemiplegic Migraine – A Case Story
We present a 28-year-old woman with a suspected hemiplegic migraine attack with left-sided hemiparalysis. Brain CT with perfusion imaging 1 h 54 min after symptom onset revealed hypoperfusion in the right hemisphere. The patient was treated with intravenous recombinant tissue plasminogen activator (rtPA) with no effect. After a subsequent intravenous verapamil infusion, the patient gained full motor function within 10 min. Brain magnetic resonance imaging (MRI) performed 5 h 46 min after symptom onset revealed diffusion restriction in the same area as the hypoperfusion on CT. There were no notable changes on T2 images. The...
Source: Case Reports in Neurology - May 5, 2017 Category: Neurology Source Type: research

Deep-learning algorithm spots carotid calcium on CT exams
A deep-learning algorithm performs comparably to human readers when it come...Read more on AuntMinnie.comRelated Reading: Everyone wins when AI becomes seamless for radiologists RapidAI launches new stroke app Use of CTA, CT perfusion up -- but for the right reasons CT mobile stroke units improve patient outcomes Do angio before CT in acute stroke patients, Barcelona team urges
Source: AuntMinnie.com Headlines - July 1, 2021 Category: Radiology Source Type: news

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning
Publication date: 2014 Source:Redox Biology, Volume 2 Author(s): Theodore Kalogeris , Yimin Bao , Ronald J. Korthuis Reductions in the blood supply produce considerable injury if the duration of ischemia is prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue damage and extend the size of an evolving infarct. Being highly metabolic organs, the heart and brain are particularly vulnerable to the deleterious effects of ischemia/reperfusion (I/R). While the pathogenetic mechanisms contributing to I/R-induced tissue injury and infarction are multifactorial, the relative importance of eac...
Source: Redox Biology - October 12, 2014 Category: Biology Source Type: research

Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart.
In conclusion, this is the first report showing that in teleosts, Nesfatin-1 potentiates mechanical cardiac performance, strongly supporting the evolutionary importance of the peptide in the control of the cardiac function of vertebrates. PMID: 26248227 [PubMed - as supplied by publisher]
Source: General and Comparative Endocrinology - August 4, 2015 Category: Endocrinology Authors: Mazza R, Gattuso A, Filice M, Cantafio P, Cerra MC, Angelone T, Imbrogno S Tags: Gen Comp Endocrinol Source Type: research

Ketamine improves neuronal recovery following spreading depolarization in peri ‐infarct tissues
We examined spreading depolarization (SD) waves in a mouse stroke model. SDs were initiated by focal potassium chloride application and propagated through a region of graded perfusion deficit created by distal middle cerebral artery (dMCA) occlusion. Longer lasting depolarizations (DC shifts measured from local field potential (LFP) electrodes) and neuronal Ca2+ transients (epifluorescence GCaMP imaging) occurred at locations with larger perfusion deficits (proximal to occlusion), as compared with remote recording sites (laser speckle contrast imaging (LSCI) of cerebral perfusion). Ketamine, at concentrations that did not ...
Source: Journal of Neurochemistry - August 19, 2023 Category: Neuroscience Authors: Katelyn M. Reinhart, Russell A. Morton, K. C. Brennan, Andrew P. Carlson, C. William Shuttleworth Tags: ORIGINAL ARTICLE Source Type: research

Electrochemical Failure of the Brain Cortex Is More Deleterious When it Is Accompanied by Low Perfusion Basic Sciences
Conclusions— The results suggest that electrochemical failure of the cortex is more deleterious when it is accompanied by low perfusion. Thus, the commitment point of the cortex is not a universal value but depends on additional factors, such as the level of perfusion.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Dreier, J. P., Victorov, I. V., Petzold, G. C., Major, S., Windmuller, O., Fernandez-Klett, F., Kandasamy, M., Dirnagl, U., Priller, J. Tags: Animal models of human disease Basic Sciences Source Type: research

Levosimendan improves contractility in vivo and in vitro in a rodent model of post‐myocardial infarction heart failure
ConclusionIn HF animals LEV improved the contractility by increasing the Ca2+ sensitivity. Furthermore loading conditions were changed, and LEV could consequently change organ perfusion. An observed increase in diastolic Ca2+ following LEV treatment and clinical implications of this should be further addressed.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - February 5, 2014 Category: Physiology Authors: Solveig Moss Kolseth, Natale Pinheiro Lage Rolim, Øyvind Salvesen, Dag Ole Nordhaug, Alexander Wahba, Morten Andre Høydal Tags: Regular Paper Source Type: research

Postischemic Reperfusion Causes Smooth Muscle Calcium Sensitization and Vasoconstriction of Parenchymal Arterioles Basic Sciences
Conclusions— The increased vasoconstriction of PAs during early postischemic reperfusion seems to be due to calcium sensitization of smooth muscle and could contribute to infarct expansion and limit neuroprotective agents from reaching their target tissue.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Cipolla, M. J., Chan, S.-L., Sweet, J., Tavares, M. J., Gokina, N., Brayden, J. E. Tags: Animal models of human disease, Acute Cerebral Infarction, Brain Circulation and Metabolism, Other Vascular biology Basic Sciences Source Type: research