Levosimendan improves contractility in vivo and in vitro in a rodent model of post‐myocardial infarction heart failure

ConclusionIn HF animals LEV improved the contractility by increasing the Ca2+ sensitivity. Furthermore loading conditions were changed, and LEV could consequently change organ perfusion. An observed increase in diastolic Ca2+ following LEV treatment and clinical implications of this should be further addressed.This article is protected by copyright. All rights reserved.

Source: Acta Physiologica - February 5, 2014 Category: Physiology Authors: Solveig Moss Kolseth, Natale Pinheiro Lage Rolim, Øyvind Salvesen, Dag Ole Nordhaug, Alexander Wahba, Morten Andre Høydal Tags: Regular Paper Source Type: research