Postischemic Reperfusion Causes Smooth Muscle Calcium Sensitization and Vasoconstriction of Parenchymal Arterioles [Basic Sciences]

Conclusions— The increased vasoconstriction of PAs during early postischemic reperfusion seems to be due to calcium sensitization of smooth muscle and could contribute to infarct expansion and limit neuroprotective agents from reaching their target tissue.

http://stroke.ahajournals.org/cgi/content/short/45/8/2425?rss=1

Source: Stroke - July 28, 2014 Category: Neurology Authors: Cipolla, M. J., Chan, S.-L., Sweet, J., Tavares, M. J., Gokina, N., Brayden, J. E. Tags: Animal models of human disease, Acute Cerebral Infarction, Brain Circulation and Metabolism, Other Vascular biology Basic Sciences Source Type: research