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Total 498 results found since Jan 2013.
Neuroprotective Effect of Moxibustion on Cerebral Ischemia/Reperfusion Injury in Rats by Downregulating NR2B Expression
CONCLUSIONS: Moxibustion can improve neurological dysfunction and decrease infarction area and neuronal apoptosis caused by cerebral ischemia/reperfusion in rats. Its neuroprotective mechanism may be related to downregulating the expression of NR2B.PMID:34733340 | PMC:PMC8560262 | DOI:10.1155/2021/5370214
Source: Evidence-based Complementary and Alternative Medicine - November 4, 2021 Category: Complementary Medicine Authors: Zhong Di Qin Guo Quanai Zhang Source Type: research
The neuroprotective effects of Insulin-Like Growth Factor 1 via the Hippo/YAP signaling pathway are mediated by the PI3K/AKT cascade following cerebral ischemia/reperfusion injury
Brain Res Bull. 2021 Oct 27:S0361-9230(21)00309-9. doi: 10.1016/j.brainresbull.2021.10.017. Online ahead of print.ABSTRACTInsulin-like growth factor 1 (IGF-1) has neuroprotective actions, including vasodilatory, anti-inflammatory, and antithrombotic effects, following ischemic stroke. However, the molecular mechanisms underlying the neuroprotective effects of IGF-1 following ischemic stroke remain unknown. Therefore, in the present study, we investigated whether IGF-1 exerted its neuroprotective effects by regulating the Hippo/YAP signaling pathway, potentially via activation of the PI3K/AKT cascade, following ischemic str...
Source: Brain Research Bulletin - October 31, 2021 Category: Neurology Authors: Pian Gong Yichun Zou Wei Zhang Qi Tian Shoumeng Han Zhou Xu Qianxue Chen Xin Wang Mingchang Li Source Type: research
Sensors, Vol. 21, Pages 7171: Segmentation of Rat Brains and Cerebral Hemispheres in Triphenyltetrazolium Chloride-Stained Images after Stroke
g Hsieh
Ischemic stroke is one of the leading causes of death among the aged population in the world. Experimental stroke models with rodents play a fundamental role in the investigation of the mechanism and impairment of cerebral ischemia. For its celerity and veracity, the 2,3,5-triphenyltetrazolium chloride (TTC) staining of rat brains has been extensively adopted to visualize the infarction, which is subsequently photographed for further processing. Two important tasks are to segment the brain regions and to compute the midline that separates the brain. This paper investigates automatic brain extraction and hemisph...
Source: Sensors - October 28, 2021 Category: Biotechnology Authors: Herng-Hua Chang Shin-Joe Yeh Ming-Chang Chiang Sung-Tsang Hsieh Tags: Article Source Type: research
Salt Substitute Cut Disease and Death Rates in Large Trial
A randomized trial recently reported in the New England Journal of Medicine focused on an important question for older adults with high blood pressure or a previous stroke: Can switching from regular salt to a 75% sodium chloride and 25% potassium chloride substitute help protect against stroke, major cardiovascular events, or death?
Source: JAMA - October 26, 2021 Category: General Medicine Source Type: research
Molecules, Vol. 26, Pages 6365: Lack of Neuroprotective Effects of High-Density Lipoprotein Therapy in Stroke under Acute Hyperglycemic Conditions
Conclusion: We observed a nonsignificant decrease in cerebral infarct size in the HDL group. The deleterious consequences of reperfusion such as hemorrhagic transformation or inflammation were not improved by HDL infusion. In acute hyperglycemia, HDLs are not potent enough to counteract the adverse effects of hyperglycemia. The addition of antioxidants to therapeutic HDLs could improve their neuroprotective capacity.
Source: Molecules - October 21, 2021 Category: Chemistry Authors: David Couret Cynthia Planesse Jessica Patche Nicolas Diotel Brice Nativel Steeve Bourane Olivier Meilhac Tags: Article Source Type: research
Integrated 16S rRNA Gene Sequencing and LC-MS Analysis Revealed the Interplay Between Gut Microbiota and Plasma Metabolites in Rats With Ischemic Stroke
This study aimed to reveal the specific asso-ciation between the microbiota and the metabolites in IS using integrated 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) analysis. Male Sprague Dawley (SD) rats were divided into three groups: normal group (n = 8, Normal), model group (n = 9, IS), and sham-operated group (n = 8, Sham). Rats in the IS group were induced by middle cerebral artery occlusion (MCAO), and rats in the Sham group received an initial anesthesia and neck incision only. A neurological function test and 2,3,5-triphenyltetrazolium chloride (TTC) staining were used to...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research
The neuroprotective effect and RNA ‐sequence analysis of postconditioning on the ischemic stroke with diabetes mellitus tree shrew model
ConclusionsIPOCs have a neuroprotective effect in a DMIS animal model that reduces infarct size and nerve cell injury. This mechanism might be related to reducing inflammation and stress responses that decreases the activity of TNF and NF- κB signaling pathways.
Source: Brain and Behavior - September 24, 2021 Category: Neurology Authors: Ling Zhao,
Shufen Tan,
Qiwei Liao,
Xia Li,
Tingyu Ke,
Shuqing Li Tags: ORIGINAL RESEARCH Source Type: research
Loop Diuretics Inhibit Ischemia-Induced Intracellular Ca2+ Overload in Neurons via the Inhibition of Voltage-Gated Ca2+ and Na+ Channels
One consequence of ischemic stroke is disruption of intracellular ionic homeostasis. Intracellular overload of both Na+ and Ca2+ has been linked to neuronal death in this pathophysiological state. The etiology of ionic imbalances resulting from stroke-induced ischemia and acidosis includes the dysregulation of multiple plasma membrane transport proteins, such as increased activity of sodium-potassium-chloride cotransporter-1 (NKCC-1). Experiments using NKCC1 antagonists, bumetanide (BMN) and ethacrynic acid (EA), were carried out to determine if inhibition of this cotransporter affects Na+ and Ca2+ overload observed follow...
Source: Frontiers in Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Source Type: research
Salt substitution reduces the rate of cardiovascular events and death
Nature Reviews Cardiology, Published online: 13 September 2021; doi:10.1038/s41569-021-00615-3In the SSaSS trial, substituting regular table salt (100% sodium chloride) with an alternative containing 25% potassium chloride reduced the rate of stroke, major cardiovascular events and all-cause death.
Source: Nature Reviews Cardiology - September 13, 2021 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Behavioral and histopathological consequences of transient ischemic stroke in the Flinders Sensitive Line rat, a genetic animal model of depression
Brain Res. 2021 Sep 4:147648. doi: 10.1016/j.brainres.2021.147648. Online ahead of print.ABSTRACTPatients with depression have an increased risk for stroke, higher mortality rates following stroke and worse functional outcomes among survivors. Preclinical studies may help to better understand the underlying mechanisms linking these two diseases, but only a few animal studies have investigated the effects of prestroke depression. The present study investigates whether Flinders Sensitive Line (FSL) rats, a genetic depression model, respond differently to focal ischemic stroke compared to control strains (Flinders Resistant L...
Source: Brain Research - September 7, 2021 Category: Neurology Authors: Denise F Happ Gregers Wegener R Andrew Tasker Source Type: research
