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Total 498 results found since Jan 2013.

LncRNA < em > PCBP1-AS1 < /em > Induces Cerebral Ischemia/Reperfusion Injury via the < em > miR-506-3p/CCL2 < /em > Axis
CONCLUSION: LncRNA PCBP1-AS1 sequesters miR-506-3p to upregulate CCL2 expression, thereby aggravating I/R injury, suggesting its potential for RNA-targeted treatment of cerebral ischemic stroke.PMID:37437927
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Zhili He Ling Chen Wei Zhang Source Type: research

MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets
In conclusion, miR-193a-5p protects against cerebral ischemic injury by restoring neutrophil N2 phenotype-associated neuroinflammation suppr ession, likely, in part, via UBE2V2 induction.
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research

Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating fat mass and obesity ‐associated—N6‐methyladenosine—acyl‐CoA synthetase long‐chain family member 4 axis
Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. Astragaloside IV (As-IV) was a promising bioactive constituent in the treatment of IS. In our study, As-IV promoted the transcription of fat mass and obesity-associated (Fto) by upregulating activating transcription factor 3(Atf3), resulting in a decrease of long-chain acyl-CoA synthetase-4 (Acsl4) N6-methyladenosine (m6A) levels, thus improving neuronal injury in IS by inhibiting ferroptosis. These findings provided a better understanding of the molecular mechanisms underlying the neuroprotective effects of As-IV and led to novel t...
Source: Journal of Neurochemistry - June 10, 2023 Category: Neuroscience Authors: Zhenglong Jin, Wenying Gao, Fu Guo, Shaojun Liao, Mingzhe Hu, Tao Yu, Shangzhen Yu, Qing Shi Tags: ORIGINAL ARTICLE Source Type: research

Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats
CONCLUSION: Dexmedetomidine has a dose-dependent protective effect on cerebral ischemic injury in rats. The neuroprotective effects of dexmedetomidine are achieved, in part, by reducing the oxidative stress response, inhibiting glial overactivation, and inhibiting expression levels of apoptosis-related proteins.PMID:37235497
Source: Alternative Therapies in Health and Medicine - May 26, 2023 Category: Complementary Medicine Authors: Jianhong Lyu Yang Zhou Min Zhang Lingling Tang Xudan Bao Zaijiao Sun Li Huang Liqin Zhao Source Type: research