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Framingham score, renal dysfunction, and cardiovascular risk in liver transplant patients
Cardiovascular (CV) events represent major impediments to the long‐term survival of liver transplantation (LT) patients. The aim of this study was to assess whether the Framingham risk score (FRS) at transplantation can predict the development of post‐LT cardiovascular events (CVEs). Patients transplanted between 2006 and 2008 were included. Baseline features, CV risk factors, and CVEs occurring after LT (ischemic heart disease, stroke, heart failure, de novo arrhythmias, and peripheral arterial disease) were recorded. In total, 250 patients (69.6% men) with a median age of 56 years (range, 18‐68 years) were included...
Source: Liver Transplantation - May 26, 2015 Category: Transplant Surgery Authors: Tommaso Di Maira, Angel Rubin, Lorena Puchades, Victoria Aguilera, Carmen Vinaixa, Maria Garcia, Nicola De Maria, Erica Villa, Rafael Lopez‐Andujar, Fernando San Juan, Eva Montalva, Judith Perez, Martin Prieto, Marina Berenguer Tags: Original Article Source Type: research

Hepatitis C Virus Infection Associated With an Increased Risk of Deep Vein Thrombosis: A Population-Based Cohort Study
Abstract: The association between the hepatitis C virus (HCV) infection and the risk of myocardial infarction (MI) and stroke has been previously investigated. However, the association between the HCV infection and the risk of venous thromboembolism (VTE) has not been extensively discussed. Using the Longitudinal Health Insurance Database 2000 (LHID2000), we selected 3686 patients with newly diagnosed HCV infection. We randomly selected 14,744 people with no HCV or hepatitis B virus (HBV) infection as comparison group and frequency matched them with patients with HCV infection according to their age, sex, and index year. T...
Source: Medicine - September 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Donor risk factors in orthotopic liver transplant: analysis of the OPTN/UNOS registry.
This study of the United Network for Organ Sharing registry data analyzed reputed donor factors using the post-MELD data and evaluated them further in HCV positive and HCV negative recipients with hepatic cirrhosis to develop a modified DRI (mDRI). We found that HCV negative cirrhotic recipients have generally higher tolerance against inferior qualities of donors than HCV positive cirrhotic patients. In addition, the results revealed the post-MELD prognostic factors that should be considered in the donor procurement processes. The group of "all recipients" and the subset of HCV positive cirrhotic recipients showed a simila...
Source: Clinical Transplants - November 20, 2015 Category: Transplant Surgery Tags: Clin Transpl Source Type: research

Relation Between Hepatitis C Virus Exposure and Risk of Osteoporosis: A Nationwide Population-Based Study
Abstract: The effect of hepatitis C virus (HCV) exposure on bone mineral density without advanced liver disease remains debated. Thus, we assessed the relation between HCV exposure and the risk of osteoporosis. From 2000 to 2011, patients aged>20 years with HCV exposure were identified from the Longitudinal Health Insurance Database 2000. Of the 51,535 sampled patients, 41,228 and 10,307 patients were categorized as the comparison and the HCV exposure cohorts, respectively. The overall incidence of osteoporosis in the HCV exposure cohort was higher than in the comparison cohort (8.27 vs 6.19 per 1000 person-years; crude ha...
Source: Medicine - November 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Hepatitis C virus and neurological damage.
Authors: Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I Abstract Chronic hepatitis C virus (HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and...
Source: World Journal of Hepatology - May 4, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Current level of evidence on causal association between Hepatitis C virus and type 2 diabetes: A review
Publication date: Available online 2 December 2016 Source:Journal of Advanced Research Author(s): Giacomo Gastaldi, Nicolas Goossens, Sophie Clément, Francesco Negro The association between hepatitis C virus (HCV) infection and type 2 diabetes (T2D) has been known for over 20 years. Cross-sectional and longitudinal studies have shown a higher prevalence and incidence, respectively, of T2D in patients with chronic HCV infection. HCV induces glucose metabolism alterations mostly interfering with the insulin signalling chain in hepatocytes, although extrahepatic mechanisms seem to contribute. Both IR and T2D accelerate the ...
Source: Journal of Advanced Research - December 2, 2016 Category: Research Source Type: research

HIV/HCV Co ‐infection and the risk of Cardiovascular Disease: A Meta‐analysis
In conclusion, individuals with HIV/HCV coinfection had an increased risk compared to those with HIV monoinfection. More research is needed to further examine the nature of this association, and response to traditional risk reductive therapies. This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - May 1, 2017 Category: Infectious Diseases Authors: Olatokunbo Osibogun, Oluseye Ogunmoroti, Erin D. Michos, Erica S. Spatz, Babatunde Olubajo, Khurram Nasir, Purnima Madhivanan, Wasim Maziak Tags: Original Paper Source Type: research

HIV/HCV coinfection and the risk of cardiovascular disease: A meta ‐analysis
In conclusion, individuals with HIV/HCV coinfection had an increased CVD risk compared to those with HIV monoinfection. More research is needed to further examine the nature of this association, and response to traditional risk‐reduction therapies.
Source: Journal of Viral Hepatitis - June 23, 2017 Category: Infectious Diseases Authors: O. Osibogun, O. Ogunmoroti, E. D. Michos, E. S. Spatz, B. Olubajo, K. Nasir, P. Madhivanan, W. Maziak Tags: ORIGINAL ARTICLE Source Type: research

Impact of aging on neurocognitive performance in previously antiretroviral-naive HIV-infected individuals on their first suppressive regimen
Conclusion: Despite continued virologic suppression and neurocognitive improvement in the cohort as a whole, older individuals were more likely to have neurocognitive impairment than younger individuals.
Source: AIDS - June 30, 2017 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Heartburn drugs linked to premature death
Conclusion This larger set of observational data finds that PPI drugs are associated with an increase in the risk of early death compared with either H2 blockers or no acid suppression drugs. This was the case for participants both with and without gastrointestinal problems. It also appears as though the longer the PPIs drugs are taken, the greater the risk of death. Considering that these drugs are widely used in the UK, these findings may cause concern. But the research has a number of important limitations: The study was conducted in a population of mostly white, older US male veterans, which might limit the ability...
Source: NHS News Feed - July 4, 2017 Category: Consumer Health News Tags: Medication Source Type: news

3 Reasons to Feel Good About Drinking Coffee on National Coffee Day
People often think about their relationship with coffee as a bad habit: maybe they splurge too frequently on $4 lattes (free coffee deals only come around once a year), or they’re so dependent on their morning pot of coffee that they can’t function without it. While there is a case to be made for not overdoing it, there are also plenty of reasons to embrace your daily coffee ritual without guilt. Yes, there’s the taste, the aroma, and the way coffee brings those fuzzy mornings into focus. But in recent years, research has also suggested that coffee has real health perks—and that for many people, the...
Source: TIME.com: Top Science and Health Stories - September 29, 2017 Category: Consumer Health News Authors: Amanda MacMillan Tags: Uncategorized Diet/Nutrition is coffee good for you National Coffee Day Source Type: news

Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.
CONCLUSIONS: A large number of discarded kidneys were procured from donors whose contralateral kidneys were transplanted with good post-transplant outcomes. PMID: 29217537 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 7, 2017 Category: Urology & Nephrology Authors: Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S Tags: Clin J Am Soc Nephrol Source Type: research

The Unraveled Link Between Antiviral Therapy and Heart Failure Hospitalization in Chronic Hepatitis C Virus Infection 　- A Nationwide Cohort Study.
CONCLUSIONS: AVT for chronic HCV infection might offer protection against HF hospitalizations, critical vascular events, and cardiovascular death beyond known beneficial effects. PMID: 29503408 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 2, 2018 Category: Cardiology Authors: Lin MS, Chung CM, Chang ML, Chen MY, Chang ST, Chu PH, Chen TH, Lin WY, Huang TJ, Lin YS Tags: Circ J Source Type: research

IJERPH, Vol. 15, Pages 513: Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
g Kao We assessed the subsequent risk of cholelithiasis development in patients with inflammatory bowel diseases (IBDs) such as Crohn’s disease (CD) or ulcerative colitis (UC). We identified 8186 patients who aged ≥20 years and were diagnosed with IBD between 2000 and 2010 as the study cohort. A total of 8186 patients without IBD were selected by frequency-matching according to age, sex, comorbidities, and the index date of diagnosis, and they were identified as the control cohort. To measure the incidence of cholelithiasis, all patients were followed up until the end of 2011. The risk of developing cholelithiasis,...
Source: International Journal of Environmental Research and Public Health - March 14, 2018 Category: Environmental Health Authors: Chien-Hua Chen Cheng-Li Lin Chia-Hung Kao Tags: Article Source Type: research

Chronic Kidney Disease (CKD) in the U.S. Hemophilia Population: A Cohort Study
Conclusions: In this interim analysis of an ongoing national prospective cohort study, older men with moderate to severe hemophilia commonly report risk factors for CKD, including HTN (51.5%), DM, viral infection, and potential renal damaging medication use. Only 11.6% had CVD. Urological symptoms were also common, including hematuria and obstructive symptoms with urination.In our cohort, 11.4% met the definition of CKD, defined as the presence of either kidney damage or GFR < 60 ml/min/1.73 m2 for ≥ 3 months. The distribution of GFR values appeared similar to the general population. As with risk factors associated w...
Source: Blood - November 21, 2018 Category: Hematology Authors: Sood, S. L., Cheng, D., Shapiro, A., Kessler, C. M., Key, N. S., Quon, D., Eyster, M. E., Manco-Johnson, M. J., Kempton, C. L., Cuker, A., Ragni, M. V., Kuriakose, P., von Drygalski, A., Kouides, P. A., Escobar, M. A., Wheeler, A. P., Wang, T.-F., Leissin Tags: 322. Disorders of Coagulation or Fibrinolysis: Poster II Source Type: research

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